Disposable electralytic transdermal drug applicator

• US 5,167,617 A
• Filed: 07/14/1989
• Issued: 12/01/1992
• Est. Priority Date: 08/18/1983
• Status: Expired due to Term

• Current Assignee: Drug Delivery Systems Incorporated
• Original Assignee: Drug Delivery Systems Incorporated
• Inventors: Sibalis, Dan
• Primary Examiner(s): Shay, Randy C.
• Application Number:
  US07/380,196
• Time in Patent Office: 1,236 Days
• Field of Search: 604/20, 128/798, 128/802, 128/803
• US Class Current: 604/20
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An electrically powered transdermal drug applicator a flexible, non-conductive substrate with a plurality of conductive coated areas forming drug reservoir electrodes with a plurality of drug reservoirs separated by occlusive dams are in electrical contact with the drug reservoir electrodes. Flexible mounting means support and removably holding the drug applicator to a limb of a body and form together therewith a combined dual assembly structure conformable to that part of said body and skin to which the drug applicator is attached. The mounting means has programmable computer means including a power source connected in an electrical circuit with the electrodes of the drug reservoirs for electrically powering the applicator and transmitting the drug programmably through the skin. A conformal cover is secured to said transdermal drug applicator and a release liner covers and protects the drug reservoirs until use.

Claims

1. A transdermal drug applicator which is electrically powered, comprising:

a flexible, non-conductive substrate having a plurality of conductive coated areas, said conductive coated areas forming drug reservoir electrodes, a plurality of drug reservoirs separated by occlusive dams and in electrical contact with said drug reservoir electrodes, flexible mounting means for supporting and removably holding said transdermal drug applicator to a limb of a body and forming together therewith a combined dual assembly structure conformable to that part of said body and skin to which said drug applicator is attached, said mounting means having programmable computer means, including a power source connected in an electrical circuit, with the electrodes of the drug reservoirs for electrically powering said applicator and transmitting the drug programmably through the skin, and a conformal cover enveloping said drug reservoir electrodes but enabling electrical contact to be made between said drug reservoir electrodes and said power source, and a release liner covering and protecting said drug reservoirs until use.

2. The transdermal drug applicator which is electrically powered according to claim 1, wherein some of the conductive coated areas interconnecting the drug reservoir electrodes are of a predetermined resistance so as to perform the function of a current limiting resistor.

3. A transdermal drug applicator as in claim 1 including a case incorporating the programmable computer means and power source, and having electrical connections to enable electrical contact with said reservoir electrodes in an overlapping manner.

4. A transdermal drug applicator as in claim 1, wherein the programmable computer means and power source are part of a sub-assembly constructed and mountable in the form of a watchband.

5. A transdermal drug applicator as in claim 4, wherein the programmable computer means and power source further include a watch.

6. A transdermal drug applicator as in claim 4, further including a watch, and wherein the conformal cover is removably attachable to said watch-band.

7. A drug applicator as in claim 1, wherein the conformal cover is coated on the outside with an adhesive.

8. An applicator as in claim 1, wherein the release liner comprises silicone for facilitating its release.

9. An applicator as in claim 1, wherein the occlusive dams comprise silicone.

10. An applicator as in claim 1, wherein the drug reservoirs are part of a removable, replaceable sub-assembly.

11. A transdermal drug applicator as in claim 1, wherein the programmable computer means and power source are part of a replaceable, removable sub-assembly.

12. An applicator as in claim 1, wherein the drug reservoir electrodes are thin and flat.

13. A transdermal drug applicator as in claim 1, wherein the drug reservoirs, drug reservoir electrodes, said occlusive dams, and non-conductive substrate comprise a foldable, removable, and replaceable sub-assembly within said conformal cover.

14. A transdermal drug applicator as in claim 1, wherein the power source comprises a battery.

15. A transdermal drug applicator as in claim 14, wherein the battery is part of said transdermal drug applicator, and said battery includes battery electrode terminals connected in the electrical circuit to said reservoir electrodes.

16. A transdermal drug applicator as in claim 15, further including means in said electrical circuit for providing an indication of the operative condition of said drug applicator.

17. A transdermal drug applicator as in claim 15, wherein said substrate is formed with 180 degree folds at opposite ends thereof with the conductive coated areas providing electrical connection between top and bottom side portions;

said drug reservoirs being in electrical contact with said drug reservoir electrodes at the bottom side and said battery electrode terminals being electrically connected to said conductive coated areas at the top side for providing current to the drug reservoirs via said conductive coated areas and said drug reservoir electrodes with one side of said drug reservoirs adapted to be applied to the skin of the patient.

18. A transdermal drug applicator as in claim 17, wherein said power source together with the conductive coated areas form substantially said electrical circuit to said drug reservoirs of said drug applicator.

19. A drug applicator as in claim 17, further including an adhesive layer firmly securing the folded opposite ends of said substrate to itself.

20. A drug applicator as in claim 19, wherein said folded opposite ends overlie each other.

21. An applicator as in claim 1, wherein the drug reservoirs comprise a gelled electrolyte.

22. A transdermal drug applicator as in claim 1, wherein the drug reservoirs further include a semipermeable membrane between high and low drug density zones within said drug reservoirs.

23. A transdermal drug applicator as in claim 1, wherein the conductive coated areas comprise a noble metal.

24. A transdermal drug applicator as in claim 1, wherein the flexible substrate is folded at opposite ends and upon itself in an overlapping manner.

25. An electrically powered transdermal drug applicator comprising:

first and second components with said first component having a power source with terminals for direct electrical connection to mating drug reservoir electrodes of a plurality of drug reservoirs in said second component;

said drug reservoir electrodes being formed from a plurality of conductive coated areas on a flexible non-conductive substrate having ends which overlap one another, with said drug reservoirs in electrical contact with the terminals of said power source indirectly via said mating drug reservoir electrodes, and a conformal cover, having at least one opening through which said terminals contact said electrodes, secured to and enveloping said plurality of drug reservoirs and said substrate and said mating drug reservoir electrodes, but leaving one side of said drug reservoirs free to be applied to the skin of a patient when said transdermal drug applicator is used, whereby said first component with said power source is reuseable and overlies said drug reservoir electrodes formed from said coated areas on said non-conductive substrate, and whereby said second component having said plurality of drug reservoirs being for replacement as desired.