Drug delivery system for the removal of dermal lesions

• US 5,167,649 A
• Filed: 04/17/1992
• Issued: 12/01/1992
• Est. Priority Date: 08/22/1988
• Status: Expired due to Term

• Current Assignee: Gerald P. Zook
• Original Assignee: Gerald P. Zook
• Inventors: Zook, Gerald P.
• Primary Examiner(s): Prebilic, Paul
• Application Number:
  US07/870,544
• Time in Patent Office: 228 Days
• Field of Search: 602/48, 602/51, 604/304, 604/307, 604/308, 604/289, 424/445, 424/446, 424/447
• US Class Current: 604/307
• CPC Class Codes: A61F 13/0203 with fluid retention members
• CPC Class Codes: A61F 2013/00506 for treating warts
• CPC Class Codes: A61F 2013/00846 with transparent or translucent part
• CPC Class Codes: A61F 2013/00893 viscoelastic oil-elastomer gel adhesives based on oil A61F2013/00693; on rubber A61F2013/00697; hydrogel-based adhesives for plasters A61F2013/00676
• CPC Class Codes: A61F 2013/00906 for transcutaneous or transdermal drugs application
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

A drug delivery system for the removal of dermal lesions which includes a pad of viscoelastic rubber and oil gel, perfused with a pharmacologically active substance, which is partially encapsulated between a first layer of oil and water impermeable material and a second layer of oil and water impermeable material. The second layer includes an aperture, corresponding to the dimension of the dermal lesion, which is smaller than, and located within, the periphery of the adjacent medicated viscoelastic rubber and oil gel pad. The two layers of oil and water impermeable material are bonded together to form a seal about the periphery of the viscoelastic rubber and oil gel pad. The surface of the patch which is affixed to a wearer'"'"'s skin is provided with a pressure sensitive adhesive. The viscoelastic rubber and oil pad and the encapsulating layers preferably are transparent.

Claims

1. A drug delivery system, in the form of a patch, having a surface affixed to a wearer'"'"'s skin, for the removal of dermal lesions, comprising:

a. a viscoelastic rubber and oil gel pad, having a first surface, an opposing second surface, and a periphery, said viscoelastic rubber and oil gel pad being perfused with a pharmacologically active substance;

b. a first layer of oil and water impermeable material, covering said first surface of said viscoelastic rubber and oil gel pad; and

c. a second layer of oil and water impermeable material, having an aperture formed therein of less dimension than said second surface of said viscoelastic rubber and oil gel pad;

said second layer of oil and water impermeable material, except for said aperture, covering said second surface of said viscoelastic rubber and oil gel pad;

said aperture being positioned upon said second surface, and within said periphery, of said viscoelastic rubber and oil gel pad;

d. said first and second layers of oil and water impermeable material being joined to form a seal about the periphery of said viscoelasic rubber and oil gel pad, so as to encapsulate said viscoelastic rubber and oil gel pad except for said aperture;

e. wherein a portion of said second surface of said viscoelastic rubber and oil gel pad is exposed through said aperture and is held in direct contact with a dermal lesion when said patch is applied to a wearer'"'"'s skin.

2. The drug delivery system for the removal of dermal lesions, as recited in claim 1, wherein said first and second layers of oil and water impermeable material and said viscoelastic rubber and oil gel pad all are substantially transparent.

3. The drug delivery system for the removal of dermal lesions, as recited in claim 1, wherein said pharmacologically active substance includes one or more agents from the following group:

cantharidin, podophyllin, salicylic acid, lactic acid, trichloracetic acid, and 5-fluorouracil.

4. The drug delivery system for the removal of dermal lesions, as recited in claim 1, wherein the rubber of said viscoelastic rubber and oil gel is a triblock copolymer of styrene-ethylene-butylene-styrene.

5. The drug delivery system for the removal of dermal lesions, as recited in claim 1, wherein the oil of said viscoelastic rubber and oil gel is Mineral Oil, U.S.P.

6. The drug delivery system for the removal of dermal lesions, as recited in claim 1, wherein, additionally, a means of affixing the surface of the patch to the wearer'"'"'s skin includes pressure sensitive adhesive.