Assay cartridge

• US 5,167,922 A
• Filed: 04/27/1990
• Issued: 12/01/1992
• Est. Priority Date: 04/27/1990
• Status: Expired due to Fees

• Current Assignee: Behringwerke Aktiengesellschaft (Sanofi )
• Original Assignee: PB Diagnostic Systems, Inc. (Sanofi )
• Inventors: Long, Ernest W.
• Primary Examiner(s): Johnston, Jill A.
• Application Number:
  US07/515,242
• Time in Patent Office: 949 Days
• Field of Search: 422/61, 422/102, 422/64, 422/58, 435/45, 435/47, 435/165, 356/244, 356/246, 220/346, 220/347, 206/560, 206/562
• US Class Current: 422/404
• CPC Class Codes: G01N 2035/00049 for loading/unloading a carousel
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack

Abstract

An assay cartridge suitable for use with automated analytical instruments which include a conveyor such as a carousel. The cartridge is configured with ledges extending cutwardly from sides thereof, preferably at the bottom of the cartridge. The conveyor incudes berths for receiving the cartridges, each berth being formed as a depressed region within a top surface of the conveyor and bounded by a floor at the bottom of the berth and opposed sidewalls and an end wall extending upwardly from the floor. The sidewalls are preferably parallel to each other. An open end of the berth, opposite the end wall serves as a port through which the cartridge is inserted and extracted from the berth. Each of the sidewalls of the berth is provided with a shoulder which extends inwardly towards a center line of the berth, and upon insertion of the cartridge, extends over the ledges of the cartridge to serve as a guide. The guide includes grooves formed between the shoulders and the floor. Cantilevered tongues are formed in the cartridge ledges, on opposite sides of the cartridge, for interaction with the grooves, regions of the floor being recessed beneath the shoulders to form depression for reception of the cantilevered tongues. The tongues are configured for interaction with the shoulders to force the tongues into the depressions for locking the cartridge into the berth. Ends of the depression are inclined to facilitate a lifting of the tongues out of the depression upon extraction of the cartridge from the berth.

Claims

1. An assay cartridge which is adapted to be operative in an analytical instrument which includes an assay cartridge carrier having a berth for receiving the cartridge and a guide structure for releasably securing the cartridge to the carrier, the cartridge comprising:

a housing which includes opposed sidewalls and a ledge extending longitudinally from each said sidewall;

tongue means being formed as a part of each of said ledges and being cantilevered from said ledges, said tongue means being configured for mating with the guide structure of an assay cartridge carrier for releasably securing the cartridge to the carrier;

assay means in said housing for receiving a sample fluid and for providing a detectable signal in response to the presence of a component of interest in said fluid; and

an aperture in said housing to permit a fluid to be provided to said assay means.

2. A cartridge according to claim 1 wherein said ledges are located at the bottom of said sidewalls of said cartridge.

3. A cartridge according to claim 1 wherein said tongue means at each of said ledges is formed as a tongue having an enlarged central portion.

4. A cartridge according to claim 1 wherein said sidewalls extend in a vertical direction between top and bottom surfaces of the cartridge, and said tongue means can flex in said vertical direction.

5. A cartridge according to claim 1 wherein said housing further includes at least one well for storage of test reagents and/or for mixing test reagents.