Membrane for electrotransport transdermal drug delivery
First Claim
1. An iontophoretic agent delivery electrode assembly adapted for placement on a body surface for iontophoretic delivery of an analgesic drug therethrough, the electrode assembly including a drug reservoir, a means for connecting said drug reservoir to a source of electrical power, and a membrane for controlling analgesic drug delivery from the electrode assembly, the membrane being positioned between said reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the analgesic drug therethrough and impeding passive flux (JP) of the analgesic therethrough, the membrane exhibiting a ratio of JEK :
- JP of at least about 2.5,the drug reservoir containing an analgesic drug to be delivered through the body surface, the drug being selected from the group consisting of fentanyl, sufentanil, analogues of fentanyl, analogues of sufentanil and pharmaceutically acceptable salts thereof.
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Abstract
A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
93 Citations
22 Claims
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1. An iontophoretic agent delivery electrode assembly adapted for placement on a body surface for iontophoretic delivery of an analgesic drug therethrough, the electrode assembly including a drug reservoir, a means for connecting said drug reservoir to a source of electrical power, and a membrane for controlling analgesic drug delivery from the electrode assembly, the membrane being positioned between said reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the analgesic drug therethrough and impeding passive flux (JP) of the analgesic therethrough, the membrane exhibiting a ratio of JEK :
- JP of at least about 2.5,
the drug reservoir containing an analgesic drug to be delivered through the body surface, the drug being selected from the group consisting of fentanyl, sufentanil, analogues of fentanyl, analogues of sufentanil and pharmaceutically acceptable salts thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- JP of at least about 2.5,
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14. An electrically powered iontophoretic delivery device including a donor electrode assembly which contains a drug reservoir, the donor electrode assembly being adapted to be placed in drug transmitting relation with a body surface, a counter electrode assembly adapted to be placed in agent transmitting relation with a body surface and a source of electrical power adapted to be electrically connected to the donor electrode assembly and the counter electrode assembly, wherein the donor electrode assembly contains:
- (1) a membrane for controlling analgesic drug delivery from the electrode assembly, the membrane being positioned between said drug reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the analgesic drug therethrough and impeding passive flux (JP) of the analgesic drug therethrough, the membrane exhibiting a ratio of JEK ;
JP of at least about 2.5, and (2) an ionized or ionizable source of an analgesic drug selected from the group consisting of fentanyl, sufentanil, analogues of fentanyl, analogues of sufentanil and pharmaceutically acceptable salts thereof. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
- (1) a membrane for controlling analgesic drug delivery from the electrode assembly, the membrane being positioned between said drug reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the analgesic drug therethrough and impeding passive flux (JP) of the analgesic drug therethrough, the membrane exhibiting a ratio of JEK ;
Specification