Nuclear magnetic resonance spectrometer

• US 5,173,661 A
• Filed: 11/06/1990
• Issued: 12/22/1992
• Est. Priority Date: 11/08/1989
• Status: Expired due to Term

• Current Assignee: Bruker Biospin GMBH (Bruker Corporation)
• Original Assignee: Bruker Analytische Messtechnik GmbH
• Inventors: Knuttel, Bertold, Muller, Wolfgang H.
• Primary Examiner(s): Tokar, Michael J.
• Application Number:
  US07/610,373
• Time in Patent Office: 777 Days
• Field of Search: 335/299, 324/300, 324/307, 324/318, 324/319, 324/320, 324/322
• US Class Current: 324/309
• CPC Class Codes: G01R 33/3875 using correction coil assemblies, e.g. active shimming

Abstract

A nuclear magnetic resonance spectrometer, in particular a nuclear spin tomograph serving to investigate biological samples, comprising a magnetic coil for generating a substantially homogeneous magnetic field in a volume under examination, and a set of shim coils for eliminating any remaining inhomogeneities of the magnetic field is characterized in that at least one additional electric conductor, preferably an additional shim coil, is provided which may be arranged in the volume under examination, in the direct vicinity of the sample, that the additional conductor is designed in such a way that it will generate an inhomogeneous magnetic field when loaded with current, and that it can be loaded with currents of a type generating inhomogeneous magnetic fields which will eliminate, at least partially, and in a selected area in the sample, local field inhomogeneities resulting from susceptibility variations within the sample, for example. This enables the accuracy of the spectroscopy results to be improved.

Claims

1. Nuclear magnetic resonance spectrometer for investigating biological sample in a volume under examination, said nuclear magnetic resonance spectrometer comprising:

magnetic coil means for generating a substantially homogeneous magnetic field in the volume under examination;

shim coil means for eliminating local inhomogeneities of the substantially homogeneous field; and

additional electric conductor means, configured and disposed in the volume under examination proximate a sample, for generating an inhomogeneous magnetic field in response to current passing therethrough,

in order to at least partially eliminate the local inhomogeneities in a selected area in the sample.

2. Nuclear magnetic resonance spectrometer according to claim 1, wherein the additional conductor means is disposed at a position in which the additional conductor means will not disturb movement of the sample into and out of the volume under examination of the nuclear magnetic resonance spectrometer.

3. Nuclear magnetic resonance spectrometer according to claim 2, wherein the additional conductor means is removable from the volume under examination.

4. Nuclear magnetic resonance spectrometer according to claim 1, wherein the additional conductor means comprises a flat coil.

5. Nuclear magnetic resonance spectrometer according to claim 4, wherein the additional conductor means comprises a plurality of flat coils of different dimensions, with the flat coils nested in one another.

6. Nuclear magnetic resonance spectrometer according to claim 1, wherein the additional conductor means comprises a plurality of shim coils disposed in a spaced apart arrangement and substantially in a single plane.

7. Nuclear magnetic resonance spectrometer according to claim 5, wherein the plurality of flat coil is disposed in a spaced apart arrangement, and substantially in a single plane.

8. Nuclear magnetic resonance spectrometer according to claim 1, wherein the additional conductor means comprises a plurality of shim coils disposed in a substantially parallel and coaxial arrangement, at a certain spacing in the direction of their axes.

9. Nuclear magnetic resonance spectrometer according to claim 5, wherein the additional conductor means comprises a plurality of coil sets disposed in a substantially parallel and coaxial arrangement, at a certain spacing in the direction of their axes.

10. Nuclear magnetic resonance spectrometer according to claim 1, further comprising at least one local shim element capable of being magnetized, said local shim element being disposed proximate the sample.

11. Nuclear magnetic resonance spectrometer according to claim 1, further comprising nuclear interferography means for detecting field inhomogeneities due to susceptibility variation.

12. Nuclear magnetic resonance spectrometer according to claim 1, wherein the additional conductor means comprises at least two electric conductors designed, arranged and interconnected in such a way that any variation of the current carried by them, due to induction resulting from the switching of gradients, is largely prevented, and at least one of the said electric conductors is disposed proximate the sample.

13. Nuclear magnetic resonance spectrometer according to claim 1, further comprising power supply means for supplying the additional conductor means with a d.c. current of adjustable magnitude.

14. Nuclear magnetic resonance spectrometer according to claim 1 further comprising a sample head, said additional conductor means being disposed inside said sample head.