Imaging process and system for transillumination with photon frequency marking

• US 5,174,298 A
• Filed: 02/27/1990
• Issued: 12/29/1992
• Est. Priority Date: 07/03/1987
• Status: Expired due to Term

• Current Assignee: General Electric CGR SA (General Electric Company)
• Original Assignee: General Electric CGR SA (General Electric Company)
• Inventors: Dolfi, Daniel, Micheron, Francois
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Nasser, Jr., Robert L.
• Application Number:
  US07/465,080
• Time in Patent Office: 1,036 Days
• Field of Search: 128/664, 128/665, 350/3.6, 350/3.67, 350/3.81, 350/3.83, 350/3.85
• US Class Current: 600/425
• CPC Class Codes: G01J 9/04 by beating two waves of a same source but of different frequency and measuring the phase shift of the lower frequency obtained
• CPC Class Codes: G01N 2021/1727 Magnetomodulation
• CPC Class Codes: G01N 2021/178 Methods for obtaining spatial resolution of the property being measured
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/47 Scattering, i.e. diffuse reflection G01N21/25, G01N21/41 take precedence G01N21/55 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/59 Transmissivity G01N21/25 takes precedence
• CPC Class Codes: G01S 15/8968 using acoustical modulation of a light beam acousto-optical light control devices G02F1/11, G02F1/33

Abstract

In an imaging process and system by transillumination of a medium illuminated by transparency by a beam, an acoustic transducer emits an acoustic wave in the medium which interferes with the beam. The frequency of the light passing through the medium is then shifted from the value of the frequency of the acoustic wave. A collimating device whose object focus is located at the intersection of the acoustic wave and the light beam collects the light diffused by the medium.

Claims

1. A transillumination imaging method comprising:

transmitting a first light beam (F1) into at least one scattering zone within a medium (H) to be imaged;

transmitting into said scattering zone within said medium at least first and second acoustic waves having a first frequency (f₁) and a second frequency (f₂), respectively, wherein the first frequency (f₁) and the second frequency (f₂) are different and the at least first and second acoustic waves interfere with the first light beam (F1), with the second acoustic wave interfering with the first light beam after the first acoustic wave interferes with the first light beam, thereby producing a second light beam (F2) produced by interference of said first and second acoustic waves with said first light beam;

producing a reference beam to interfere with the second light beam; and

applying said second light beam and said reference to a detector and measuring a quantity of light scattered by said scattering zone by detecting a light which has been subjected to a translation of the first frequency (f₁) and the second frequency (f₂).

2. Method according to claim 1, further comprising:

transmitting into the scattering zone of said medium a number of first acoustic waves having different frequencies (f₁, f₂, . . . f_i) which each interfere independently with the first light beam (F1); and

successively detecting light which has been subjected to translations of each of said frequencies (f₁, f₂, . . . f_i).

3. Method according to claim 1, wherein said step of producing a reference beam comprises:

producing a light beam having a frequency which is slightly shifted with respect to the frequency of the first light beam.

4. A system for transillumination imaging of a medium comprising:

laser means for illuminating a scattering zone in the medium by means of a first laser beam having a first frequency (F1);

at least first and second acoustic transducers mounted adjacent to each other for emitting within the medium respective acoustic waves which are not collinear with the first laser beam and which have respective predetermined frequencies (f₁, f₂), said acoustic waves intercepting and interfering with said first laser beam (F1) in said scattering zone;

an optical collimator, placed in the path of said first laser beam and having an object focus located at said scattering zone in said medium for collimating light of said first laser beam which is intercepted by said acoustic waves from said at least first and second acoustic transducers, which produces a collimated second laser beam (F2);

said laser means comprising means for producing a reference laser beam (F3) to interfere with said second laser beam; and

a detector optically coupled to said reference laser beam and said collimated second laser beam for measuring the quantity of light scattered in said scattering zone, including frequency filtering means for detecting light of the collimated second laser beam which has been subjected to a frequency translation relative to said first frequency due to interference with said first and second acoustic waves;

said second acoustic transducer mounted adjacent the first acoustic transducer and positioned on the opposite side of the first transducer with respect to the side of the medium on which the light beam is incident, the second acoustic wave emitted by said second transducer interfering with the first light beam but not interfering with the first acoustic wave and irradiating the medium downstream of where the medium is irradiated by said first acoustic wave with respect to the side of the medium on which the first light beam is incident.

5. The system according to claim 4, comprising:

a plurality of said acoustic transducers for producing a plurality of acoustic waves having respective frequencies (f₁, f₂, . . . f_i) and which are located successively displaced along a path of said first laser beam and which transmit respective acoustic waves into said respective portions of said medium in the path of said first laser beam.

6. Imaging system in accordance with claim 4, wherein said laser means comprises:

;

a source laser for producing a source beam (FS);

beam splitter means, which is placed on the path of said source beam (FS), for dividing the source beam so as to provide said first laser beam (F1) and said reference laser beam (F3), and

beam coupler means for retransmitting to the detector (D) said reference laser beam (F3) and the second beam (F2) which emerges from the medium (H).

7. Imaging system in accordance with claim 6, wherein said laser means comprises a frequency shifting device (CF) which is placed between said beam splitter means and said detector for producing said reference beam with a frequency which is slightly displaced with respect to the frequency of the first beam (F1).

8. Imaging system in accordance with claim 7, wherein the frequency shifting device (CF) comprises an acoustooptical system.

9. Imaging system in accordance with claim 7, wherein the frequency shifting device (CF) comprises a mirror (M2) mounted on a piezoelectric device.

10. Imaging system in accordance with claim 4, comprising:

a holographic filtered device placed on the path of the second beam; and

means for applying to said device a pumping beam whose frequency is that of the first light beam (ω

) increased by the frequency of the acoustic wave (f1).

11. Imaging system in accordance with claim 10, wherein the filtering device (AMP) acts in reflection and that the system comprises a beam splitter (S'"'"') placed between the filtering device (AMP) and the medium (H) in order to return the filtered image of the medium (H) to the detector (D).

12. Imaging system in accordance with claim 4, comprising a polarizer (P) which is placed on the path of the source light beam (FS) and linearly polarizes said beam.

13. Imaging system in accordance with claim 4, wherein the detector (D) is a photodiode.

14. Imaging system in accordance with claim 4, wherein the detector (D) comprises a series of aligned detectors.

15. Imaging system in accordance with claim 4, wherein the detector (D) comprises a matrix of detectors.

16. Imaging system in accordance with claim 4, wherein it comprises a device for displaying an image of a zone of the medium (H) supplied by the first acoustic transducer (TA1), the detector (D) being also intended to permit display of an optical image of the same zone.

17. Imaging system in accordance with claim 4, comprising:

on the path of the first light beam (F1) a semi-reflecting optical device (S2) which permits transmission of the first light beam to the medium and reflects the light which comes from the medium;

another optical collimation device O'"'"' in which the object focus reflected by the semi-reflecting optical device (S2) is located at said object focus and receives the light reflected by the semi-reflecting optical collimation device;

a second detector (D2) placed on the path of the light retransmitted by the semi-reflecting optical device (S2) and the optical device (O'"'"').

18. Imaging system in accordance with claim 4, comprising:

means for shifting the optical devices which transmit the first, second and reference light beams with respect to the medium.

19. Imaging system in accordance with claim 18, wherein the shifting means comprises waveguides for transmitting the first and reference light beams.

20. Imaging system in accordance with claim 19, wherein the waveguides are optical fibers.

21. Imaging system in accordance with claim 18, comprising, on the path of the first beam (F1), a light beam translating device (TR1) which makes it possible to shift the direction of transmission of the first beam parallel to a predetermined direction.

22. Imaging system in accordance with claim 21, comprising, on the path between said beam splitter means and said detector, a second beam translating device (TR2) for shifting the direction of transmission of said reference beam parallel to a predetermined direction.

23. Imaging system in accordance with claim 22, wherein each of said first and second beam translating devices (TR1, TR2) comprises two reflection devices having reflecting surfaces which are parallel to each other and movable in rotation.

24. Imaging system in accordance with claim 22, wherein each beam translating device (TR1, TR2) comprises two reflection devices having reflecting surfaces which are parallel to each other and movable in translation.