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Apparatus for determining DNA sequences by mass spectrometry

  • US 5,174,962 A
  • Filed: 01/24/1990
  • Issued: 12/29/1992
  • Est. Priority Date: 06/20/1988
  • Status: Expired due to Fees
First Claim
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1. A DNA sequence analyzer comprising:

  • (a) a means for separating chain terminated DNA sequences labeled with an isotope according to size;

    (b) a combustion chamber which converts the elements of chain terminated DNA sequence including the isotope into oxides;

    (c) a means for transporting the chain terminated DNA sequences from the means for separating the chain terminated DNA sequences to the combustion chamber;

    (d) a mass spectrometer operatively associated with the combustion chamber for analyzing oxides of isotopes of different mass bound to the chain terminated DNA sequences in a relationship that associated the mass of an isotope with a terminal nucleotide of the DNA sequence.

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