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Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group

  • US 5,175,269 A
  • Filed: 04/29/1991
  • Issued: 12/29/1992
  • Est. Priority Date: 01/30/1984
  • Status: Expired due to Term
First Claim
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1. A compound of the formula


  • space="preserve" listing-type="equation">A.sup.3 --(--X--R.sup.1 --E--)m
whereA3 is an oligo- or polynucleotide having at least one modifiable reactive group consisting of amino, hydroxy, cis OH, halide, aryl, imidazoyl, carbonyl, carboxyl, thiol or a residue comprising an activated carbon where the modifiable group is contained within or attached to a sugar or a phosphate moiety;

--X-- is selected from the group consisting of;

--NH--CO--, --NH--C(NH)--, --N═

N--, --NH--SO2 --, --OSO2 --, --NH--N═

N--, --NH--CH2 --, --CH2 --NH--, --O--CO--, --NH--CO--CH2 --S, --NH--CO--CH2 --NH--, --O--CO--CH2 --, --S--CH2 --, --O--CO--NH--;

--R1 -- is ##STR52## or a C1 -C10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH;

--Y-- is a direct bond to --E--, or --Y-- is --E--R2 -- where R2 -- is a C1 -C10 branched or unbranched alkyl;

Za is chlorine, bromine or iodine;

--E-- is O, NH or an acyclic divalent sulfur atom;

m is an integer from 1 to the total number of modified reactive groups on said oligo- or polynucleotide; and

which compound has at least one couplable reactive site thereon which is attached to an entity capable of generating a signal.

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