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Transgenic mice depleted in mature T-cells and methods for making transgenic mice

  • US 5,175,384 A
  • Filed: 12/05/1988
  • Issued: 12/29/1992
  • Est. Priority Date: 12/05/1988
  • Status: Expired due to Term
First Claim
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1. A transgenic mouse having a phenotype characterized by the substantial absence of mature T-cells otherwise naturally occurring in said mouse, said phenotype being conferred by a transgene contained in the somatic and germ cells of said mouse, said transgene comprising the Δ

  • V-TCRβ

    DNA fragment which encodes a T-cell antigen receptor polypeptide variant, and said polypeptide variant being incapable of mediating T-cell maturation in said transgenic mouse.

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