System and method for rapid vascular drug delivery

• US 5,176,643 A
• Filed: 04/29/1991
• Issued: 01/05/1993
• Est. Priority Date: 04/29/1991
• Status: Expired due to Term

• Current Assignee: Resuscitation Solution, Inc. (Nihon Kohden Corporation)
• Original Assignee: George C. Kramer
• Inventors: Kramer, George C., Thomas, William B., Wilson, Jay
• Primary Examiner(s): Hirsch, Paul J.
• Application Number:
  US07/692,674
• Time in Patent Office: 617 Days
• Field of Search: 604/134, 604/135, 604/136, 604/137, 604/272, 604/274
• US Class Current: 604/135
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/3247 Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/3291 Shafts with additional lateral openings
• CPC Class Codes: A61N 1/0575 with drug delivery

Abstract

A device (10) for rapid vascular drug delivery, particularly through the adult sternum or the pediatric tibia, incorporates a cylindrical syringe body (12), fitted with a needle (14). The syringe body is held in a cylindrical main housing (16) having a front barrel (18) with an orifice (20) through which the needle (14) may be extended. A cylindrical actuation handle (22) fits over end (24) of the main housing (16) for sliding movement along the main housing. A syringe plunger (26) contacts drive plunger (28) and extends into the syringe body (12) from end (30) to confine liquid medication (32) in the syringe body (12). A main spring (34) extends between the drive plunger (28) and the actuation handle (22) to bias the actuation handle (22) in its extended position. A needle return spring (38) extends between the front barrel (18) and the syringe body (12) to bias the needle to its retracted position. The drive plunger (28) has an annular peripheral socket (42) for one or more lock balls (44) which engage one or more openings (45) on the main housing (16) to lock the drive plunger in position with respect to the syringe body (12). A mating annular lock ball trip pocket (46) is positioned on inside surface (48) of the actuation handle to allow the device (10) to be fired when the lock ball(s) in socket (42) reach the pocket (46).

Claims

1. A device for delivery of a drug in liquid form, which comprises a main housing having a front end and a rear end, a forward directed aperture on the front end of said main housing, a syringe body having a front end and a rear end, said syringe body being slideable positioned in said main housing, a needle having a central bore communicating with at least one opening proximate to a tip of said needle, said needle being attached to the front end of said syringe body, communicating with an interior of said syringe body and being positioned to extend through the aperture of said main housing, an actuation handle extending in telescoping fashion over the rear end of said main housing, a drive plunger extending from the rear ends of said syringe body and said main housing into said actuation handle, a drive spring capable of exerting an extending force between said drive plunger and said actuation handle, a needle return spring connected between the front end of said said main housing for engaging said drive plunger in position at the rear end of said syringe body, and a means placed on the front end of said main housing for locking said drive plunger in position and for unlocking said drive plunger from the rear end said syringe body causing said needle to be releasibly extended from the front end of said main housing.

2. The device for delivery of a drug in liquid form of claim 1 in which said means for engaging said drive plunger in position at the rear end of said syringe body comprises an annular pocket on said drive plunger for holding at least one lock ball and at least one opening in said main housing into which said at least one lock ball extends.

3. The device for delivery of a drug in liquid form of claim 2 in which said means for unlocking said drive plunger from the rear end of said syringe body comprises at least one receptacle positioned to allow said at least one lock ball to extend into said at least one receptacle when said at least one opening is opposite said at least one receptacle.

4. The device for delivery of a drug in liquid form of claim 1 additionally comprising a protective cover having a front end and a rear end, said protective cover being positioned over the front end of said main housing, the front end of said protective cover extending beyond the front end of said main housing at least a distance equal to the distance said needle extends through the aperture of said main housing when said device is operated, said protective cover having a corresponding aperture to the aperture of said main housing, the rear end of said protective cover extending into said actuation handle, said protective cover being initially movable rearward along said main housing in telescoping fashion over the front end of said main housing, and a locking mechanism on said protective cover for preventing said protective cover from being moved rearward along said main housing again, after initially being moved rearward along said main housing.

5. The device for delivery of a drug in liquid form of claim 4 in which said locking mechanism comprises a lock having a plurality of spring tabs extendable outward from said protective cover to engage said actuation handle and a sleeve positioned over said spring tabs to hold them from extending outward until said protective cover is initially moved rearward along said main housing.

6. The device for delivery of a drug in liquid form of claim 1 in which said needle has a taper along its length, a conical, orifice free tip, and said at least one opening comprises a plurality of orifices positioned circumferentially on said needle at different distances from said tip.

7. The device for delivery of a drug in liquid form of claim 6 in which each of said plurality of orifices is connected to one of a like plurality of substantially vertical slits on said needle.

8. A device for delivery of a drug in liquid form to red marrow, which comprises a main housing having a front end and a rear end, a forward directed aperture on the front end of said main housing, a syringe body having a front end and a rear end, said syringe body being slideable positioned in said main housing, a needle having a central bore communicating with at least one opening proximate to a tip of said needle, said needle being attached to the front end of said syringe body, communicating with an interior of said syringe body and being positioned to extend through the aperture of said main housing with a force exceeding 25 pounds such that the needle is capable of being releasibly extended with sufficient momentum to penetrate a patient'"'"'s skin and enter the red marrow inside a bone and to rapidly discharge the drug in liquid form from the syringe, through the needle and into the red marrow.

9. The device for delivery of a drug in liquid form to red marrow of claim 8 further comprising a drive plunger capable of being engaged with the rear end of said syringe body, a drive spring attached to said plunger to drive said needle into the red marrow and to subsequently drive said plunger from the rear end of said syringe body.

10. The device for delivery of a drug in liquid form to red marrow of claim 8 in which said means for discharging the drug in liquid from comprises a syringe plunger engaged by said drive plunger.

11. The device for delivery of a drug in liquid form to red marrow of claim 8 in which said needle has a taper along its length, a conical, orifice free tip, and said at least one opening comprises a plurality of orifices positioned circumferentially on said needle at different distances from said tip.

12. The device for delivery of a drug in liquid form to red marrow of claim 11 in which each of said plurality of orifices is connected to one of a like plurality of substantially vertical slits on said needle.

13. A device for delivery of a drug in liquid form, which comprises a main housing having a front end and a rear end, a forward directed aperture on the front end of said main housing, a syringe body having a front end and a rear end, said syringe body being slideable positioned in said main housing, a needle having a central bore communicating with at least one opening proximate to a tip of said needle, said needle being attached to the front end of said syringe body, communicating with an interior of said syringe body and being positioned to extend through the aperture of said main housing, a drive plunger extending from the rear end of said syringe body, a means on said main housing and engaging said drive plunger to lock and unlock said drive plunger in position at the rear end of said syringe body, a means connected to said drive plunger for applying propelling force to said drive plunger which exceeds 25 pounds to move said syringe body along said main housing in a first direction to releasibly extend said needle approximately 8 mm to 15 mm from the aperture when said device is pressed against a patient and to expel the drug from said syringe body into the patient, and a means connected to said syringe body to move said syringe body in a second direction opposite to the first direction for withdrawn said needle into said aperture when said device is no longer pressed against a patient.

14. The device for delivery of a drug in liquid form of claim 13 additionally comprising a protective cover having a front end, said protective cover being positioned over the front end of said main housing, the front end of said protective cover extending beyond the front end of said main housing at lest a distance equal to the distance said needle extends through the aperture of said main housing when said device is operated, said protective cover having a corresponding aperture to the aperture of said main housing, said protective cover being initially movable rearward along said main housing in telescoping fashion over the front end of said main housing, a locking mechanism on said protective cover for preventing said protective cover from being moved rearward along said main housing again, after initially being moved rearward along said main housing, and a means for biasing said protective cover forward in extended position beyond the front end of said main housing.

15. The device for delivery of a drug in liquid form of claim 13 in which said means for applying propelling force to said drive plunger and to expel the drug from said syringe body comprises a first spring, and said means to move said syringe body in a second direction comprises a second spring having a lesser spring force when compressed than said first spring.