Transesophageal probe having simultaneous pacing and echocardiographic capability, and method of diagnosing heart disease using same

• US 5,178,149 A
• Filed: 11/06/1989
• Issued: 01/12/1993
• Est. Priority Date: 11/06/1989
• Status: Expired due to Fees

• Current Assignee: George E. Pool, Michael Imburgia
• Original Assignee: George E. Pool, Michael Imburgia
• Inventors: Pool, George E., Imburgia, Michael
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US07/432,543
• Time in Patent Office: 1,163 Days
• Field of Search: 128/419 P, 128/419 PG, 128/671, 128/642, 128/660.10, 128/662.06, 128/4
• US Class Current: 600/463
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61N 1/0517 Esophageal electrodes

Abstract

Transesophageal echocardiographic probe having simultaneous cardiac pacing and echocardiographic capability. The inventive probe is provided with transducer means to provide echocardiographic imaging of the ventricular wall motion of a patient'"'"'s heart as it is stress-paced by a novel pacing electrode connectable to the periphery of the transesophageal probe. By locating the pacing electrode upon the periphery of the probe a selected distance from the echo transducer, placement of the pacing electrode to produce optimal atrial pacing can be optimized. A method setting forth a diagnostic protocol to achieve echocardiographic diagnosis is also disclosed.

Claims

1. A transesophageal instrument to perform simultaneous pacing and echocardiography of an organ of a patient, comprising:

an elongated probe adaptable to be inserted into the esophagus of a patient having a distal end and a proximal end;

echo producing means comprising a transducer capable of producing signals receivable and convertible into sonographic images located at a selected location near the distal end of said probe to produce a signal indicative of the sonic energy emitted by said echo producing means reflecting sonic energy off an organ of said patient and convertible into sonographic images;

organ stimulating and pacing means adaptable to the periphery of said probe and located a selected distance from said echo producing means connectable to an electrical stimulus generating device;

signal transmission means connectable to said echo producing means to transmit said signal produced by said echo producing means to a receiver to receive said signal from said echo producing means and convert said signal into a sonogram indicative of the motion of said organ of said patient; and

connecting means connectable to said organ stimulating and pacing means and said stimulus generating device to transmit stimuli produced by said stimulus generating means to said organ stimulating means,

whereby said probe is capable of simultaneously stimulating and pacing said organ of said patient while producing a real-time sonogram of said paced organ.

2. The invention of claim 1 wherein said organ stimulating and pacing means comprises conductive wire having a band portion at its distal end of selected length attachable to said probe a selected distance around the circumference of the periphery of said probe.

3. The invention of claim 2 wherein said selected distance comprises at least one-fourth of the circumference of said probe at the location of attachment.

4. The invention of claim 2 wherein said selected distance comprises at least one-half of the circumference of said probe at the location of attachment.

5. The invention of claim 2 wherein said selected distance comprises at least three-fourths of the circumference of said probe at the location of attachment.

6. The invention of claim 2 wherein said distal end of said organ stimulating and pacing means is attachable to said probe substantially the full circumference of said periphery of said probe at the location of attachment.

7. The invention of claim 2 wherein said band of said distal end of said organ stimulating and pacing means comprises generally flattened conductive material connectable to said conductive wire of said organ stimulating and pacing means.

8. The invention of claim 7 wherein said echo producing means comprises a transducer capable of producing signals receivable and convertible into sonographic images.

9. The invention of claim 7 wherein said organ stimulating and pacing means comprises electrical pulse generating means capable of producing electrical pulses of selected interval and strength to stimulate and pace said organ at selected activity level.

10. The invention of claim 7 wherein said organ stimulating and pacing means includes a pair of conductive leads connectable in spaced relationship to said organ stimulating and pacing means, the more proximal of said leads connectable to the positive terminal of said organ stimulating and pacing means and the second of said leads connectable to the negative terminal of said organ stimulating and pacing means.

11. The invention of claim 2 wherein said selected distance between said echo producing means and said organ stimulating means is between 5 and 15 centimeters.

12. The invention of claim 11 wherein said selected distance is about 10 centimeters.

13. A cardiologic pacing device comprising a transesophageal probe insertable into the esophagus of a patient, having a pair of ring electrodes in selected space relation to each other peripherally attachable a selected peripheral distance around the periphery of said probe and located a selected distance from the distal end of said probe to place said pair of ring electrodes in selected position in relation to the patient'"'"'s heart, each of said ring electrodes including a conductive lead having a proximal end connectable to the positive or negative output terminal of an electrical cardiologic pulse generator and a distal end connectable to said ring electrodes, whereby said pacing device is capable of imparting a signal from said pulse generator to the heart of said patient.

14. The invention of claim 13 wherein said leads comprises a coaxial conductive material.

15. The invention of claim 14 wherein said connected relationship comprises circumferential relationship with a selected proportion of the outer periphery of said probe.

16. The invention of claim 13 wherein said selected peripheral relationship of said pair of ring electrodes is at least one-fourth of said outer periphery of said probe.

17. The invention of claim 13 wherein said selected peripheral relationship of said pair of ring electrodes is at least one-half of said outer periphery of said probe.

18. The invention of claim 13 wherein said selected peripheral relationship of said pair of ring electrodes is at least three-fourths of said outer periphery of said probe.

19. The invention of claim 13 wherein said selected peripheral relationship of said pair of ring electrodes is substantially all of said outer periphery of said probe.

20. The invention of claim 13 wherein said conductive material and said termini are copper.

21. The invention of claim 13 or 13 wherein said copper of said pair of leads or said coaxial cable is coated with flexible non-conductive insulating material.

22. The invention of claim 13 wherein said spaced relationship between said pair of ring electrodes comprises about 10 millimeters.

23. Method of diagnosing heart disease by simultaneously transesophageally electrically stimulating and pacing the heart of a patient and producing and recording a transesophageal sonogram of the wall motion of the patient'"'"'s heart in response to the pacing signal comprising the steps of:

determining the patient'"'"'s at-rest heart rate and using same as a base reference point;

inserting an elongated transesophageal probe into the esophagus of a patient, said probe having echo producing means thereon located near the distal end thereof connectable to a sonogram recording device connectable to the proximal end thereof, and having a pacing electrode comprising a pair of ring electrodes in spaced relationship a selected distance from said echo producing means attachable to the outer periphery of said probe and connectable from the proximal end of said probe to an electrical pulse generator capable of producing electrical pulses to induce ventricular activity of the patient'"'"'s heart;

passing the probe lower into the esophagus until said sonogram recording device reveals a first image indicative of a selected area of the patient'"'"'s heart and fixing the position of said probe within the esophagus of the patient when the sonogram recording device reveals a second sonographic image indicative of the desired area of the patient'"'"'s heart;

initiating selected pulses from said electrical pulse generator to said pacing electrode whereby activity of the patient'"'"'s heart is increased by stimuli from said pulse generator; and

producing a continuous sonogram of motion of the selected area of the patient'"'"'s heart during said stimulated heart activity, whereby coronary disease may be detected by observing abnormal heart motion in said second sonographic image produced in response to said stimulated heart activity.

24. The invention of claim 23 wherein said first sonographic image is of the atria of the patient'"'"'s heart and said second sonographic image is of ventricular wall motion of the patient'"'"'s heart.

25. The invention of claim 24 including the additional steps of:

after said first sonographic image of the patient'"'"'s atria is produced, passing said probe lower in the patient'"'"'s esophagus a selected distance until the sonogram recording device produces said second sonographic image indicative of the left ventricle of the patient'"'"'s heart; and

rotating said probe within the patient'"'"'s esophagus to place said pair of ring electrodes in optimal pacing position with respect to the patient'"'"'s heart while maintaining an optimal image of said second sonographic image of said left ventricle of the patient'"'"'s heart.

26. The method of claim 25 wherein said selected pulses from said cardiac pacing device begin with a pulse duration of nine (9) milliseconds and a strength of about five (5) milliamps, increased at intervals of two milliamps until sustained atrial capture is attained.

27. The method of claim 26 including the additional steps of stimulating increased activity of the patient'"'"'s heart by generating increased selected pulses from said pulse generating means until the patient'"'"'s heart attains the greater of 100 beats per minute or an increase of 20 beats per minute over the at-rest heart rate for the patient, then determining the presence or absence of coronary artery disease by assessing the ventricular wall motion by reference to said second image produced by said sonogram recording device.

28. The method of claim 27 including the additional steps of increasing the pulses from said pulse generating means to stimulate increase in the patient'"'"'s heart rate by twenty beats per minute, holding said increased heart rate at said increased rate for two minutes, increasing the patient'"'"'s heart rate by twenty beats per minute every two minutes until the first to occur of attaining selected peak heart rate or chest pain occurs, and assessing the second image produced by said sonogram recording device of the patient'"'"'s ventricular wall motion at every twenty beat increase interval to determine the presence of absence of coronary artery disease.

29. The method of claim 28 including the additional step of utilizing electrocardiographic monitoring of the patient in conjunction with said simultaneous pacing and echocardiagraphy by said single transesophageal probe, whereby said method is terminated if the patient develops an abnormal electrocardiogram before said selected peak heart rate is attained.