Impedance cardiograph and method of operation utilizing peak aligned ensemble averaging

• US 5,178,154 A
• Filed: 09/18/1990
• Issued: 01/12/1993
• Est. Priority Date: 09/18/1990
• Status: Expired due to Term

• Current Assignee: CHF Solutions, Inc.
• Original Assignee: Sorba Medical Systems, Inc.
• Inventors: Christman, Norbert T., Ackmann, James J., Ebert, Thomas J.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US07/584,319
• Time in Patent Office: 847 Days
• Field of Search: 128/695, 128/696, 128/693, 128/670, 128/713, 128/734, 364/413.02, 364/413.03, 364/413.06
• US Class Current: 600/526
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

Parameters of cardiac activity can be derived from detecting thoracic impedance changes in a patient. An excitation signal is applied between a first pair electrodes located on the patient'"'"'s forehead and torso. The voltage across another pair of electrodes positioned between the first pair is sensed to provide a first signal representing the impedance. The derivative of the first signal produces a second signal. Samples of the second signal taken during a number of cardiac cycles are ensemble averaged to minimized respiratory artifacts. Different criteria, such as the relationship between the second signal and an electrocardiographic signal, are employed to accept segments of the second signal which occur during different cardiac cycles. Samples of the accepted second signal segments for a number of cardiac cycles are ensemble averaged to minimize respiratory artifacts. The ensemble averaged data is employed to calculate cardiac stroke volume and cardiac output.

Claims

1. An impedance cardiograph comprising:

means for applying an excitation signal to the thorax of an animal;

means, responsive to the excitation signal, for producing a first electrical signal which varies with thoracic impedance changes of the animal;

means for producing a second electrical signal that corresponds to the first derivative of the first electrical signal;

means for generating a plurality of periodic samples of the second electrical signal, the samples being divided into a number of groups with the samples in each group representing the second electrical signal during a different cardiac cycle of the animal;

means for identifying a signal sample in each group which occurs during a cardiac ejection interval and which corresponds to the smallest rate of change of the thoracic impedance;

means for ensemble averaging the groups of the samples of the second electrical signal to produce a set of ensemble averaged signal samples, said means for ensemble averaging aligning each group of samples of the second electrical signal about a sample in each group which occurs during a cardiac ejection interval and which corresponds to the smallest rate of change of the thoracic impedance; and

means for computing a cardiac performance parameter value from the ensemble averaged signal samples.

2. The impedance cardiograph as recited in claim 1 further comprising means for selecting the groups of samples of the second electrical signal for ensemble averaging based upon whether each group of samples meets a predefined acceptance criteria.

3. The impedance cardiograph as recited in claim 2 wherein said means for selecting includes:

means for measuring an interval between samples of a group which correspond to two predefined points on the second electrical signal; and

means for determining whether the interval for each group is within a predefined range of values.

4. The impedance cardiograph as recited in claim 2 further comprising a means for producing an electrocardiogram signal having a QRS wave during each cardiac cycle.

5. The impedance cardiograph as recited in claim 4 wherein said means for selecting includes:

means for measuring an interval between a reference point on the QRS wave and a predefined point on the second electrical signal during each of the cardiac cycles; and

means for determining whether the measured interval is within a predefined range of values.

6. The impedance cardiograph as recited in claim 4 wherein said means for selecting includes:

means for measuring a first interval point on the QRS wave and a predefined point on the second electrical signal during each of the cardiac cycles; and

means for determining whether the measured interval is within one standard deviation of an arithmetic mean of a plurality of first intervals.

7. The impedance cardiograph as recited in claim 6 wherein said means for selecting further includes:

means for measuring a second interval between a reference point on two consecutive QRS waves in the electrocardiogram signal; and

means for determining whether the first interval is less than a given fraction of the second interval.

8. The impedance cardiograph as recited in claim 4 wherein said means for selecting includes:

means for determining whether a QRS wave has a duration that is within an given range of values; and

means for determining whether a QRS wave has a height that is within an given range of values.

9. The impedance cardiograph as recited in claim 4 wherein said means for selecting includes:

means for selecting a QRS wave as a reference QRS wave;

means for deriving a shape fit value representing the degree to which another QRS wave matches the reference QRS wave; and

means for determining whether the shape fit value is within a given range of shape fit values.

10. The impedance cardiograph as recited in claim 4 wherein said means for selecting includes:

means for measuring intervals between a reference point on each consecutive QRS wave in the electrocardiogram signal; and

means for determining whether each interval is within a given range of standard deviations of an arithmetic mean of a plurality of the intervals.

11. The impedance cardiograph as recited in claim 2 further comprising a means for sensing blood pressure of the animal.

12. The impedance cardiograph as recited in claim 11 wherein said means for selecting includes:

means for measuring a first interval between the occurrence of systolic blood pressure and a predefined point on the second electrical signal during each of the cardiac cycles; and

means for determining whether each measured interval is within a defined range of reference values.

13. The impedance cardiograph as recited in claim 12 wherein the defined range of reference values is specified by a given number of standard deviations of an arithmetic mean of a plurality of the first intervals.

14. The impedance cardiograph as recited in claim 12 wherein said means for selecting further includes:

means for measuring a second interval between consecutive occurrences of systolic blood pressure; and

means for determining whether the first interval is less than a given fraction of the second interval.

15. An impedance cardiograph comprising:

means for applying an excitation signal to the thorax of an animal;

means, responsive to the excitation signal, for producing an electrical signal which varies with thoracic impedance changes of the animal;

means for producing an electrocardiogram signal containing a cardiac QRS wave;

means for determining a heart rate of the animal from the electrocardiogram signal;

means for selecting segments of the electrical signal for which a predefined point of a segment occurs within a given interval from an occurrence of a predetermined point on a cardiac QRS wave, said means for selecting including means for determining the given interval; and

means, responsive to said first means for selecting, for computing a cardiac performance parameter value from the selected segments of the electrical signal.

16. The impedance cardiograph as recited in claim 15 wherein the predetermined point on a cardiac QRS wave is a peak of an R spike.

17. The impedance cardiograph as recited in claim 16 wherein the predefined point of a segment of the electrical signal corresponds to the smallest rate of change of the thoracic impedance.

18. An impedance cardiograph comprising:

means for applying an excitation signal to the thorax of an animal;

means, responsive to the excitation signal, for producing a first electrical signal which varies with thoracic impedance changes of the animal;

means for producing a second signal corresponding to the first derivative of the first electrical signal;

means for producing an electrocardiogram signal having a QRS wave during each cardiac cycle;

means for generating a plurality of periodic samples of the first electrical signal, second electrical signal and the electrocardiogram signal, the samples of each signal being divided into a number of groups with the samples in each group representing the respective signal during a different cardiac cycle of the animal;

means for averaging the samples of the first electrical signal to produce an average thoracic impedance value;

means for ensemble averaging the groups of the samples of the second electrical signal to produce a first set of ensemble averaged signal samples, said means for ensemble averaging aligning each group of samples of the second electrical signal about a sample in each group which occurs during a cardiac ejection interval and which corresponds to the smallest rate of change of the thoracic impedance;

means for ensemble averaging the groups of the samples of the electrocardiogram signal to produce a second set of ensemble averaged signal samples; and

means for computing cardiac stroke volume from the first set of ensemble averaged signal samples and the average thoracic impedance value.

19. The impedance cardiograph as recited in claim 18 further comprising means for displaying the first and second sets of ensemble averaged signal samples.

20. The impedance cardiograph as recited in claim 18 further comprising means for selecting the groups of samples of the second electrical signal for ensemble averaging based upon whether each group of samples meets a predefined acceptance criteria.

21. The impedance cardiograph as recited in claim 20 wherein said means for selecting includes means for determining whether each cardiac cycle has a duration within a first predefined range of values;

and whether the QRS wave has a duration within a second predefined range of values.

22. The impedance cardiograph as recited in claim 20 wherein said means for selecting includes:

means for selecting a QRS wave as a reference QRS wave;

means for deriving a shape fit value representing the degree to which another QRS wave matches the reference QRS wave; and

means for determining whether the shape fit value is within a given range of shape fit values.

23. The impedance cardiograph as recited in claim 20 wherein said means for selecting includes:

means for measuring an interval between a reference point on the QRS wave and a predefined point on the second electrical signal during each of the cardiac cycles; and

means for determining whether the measured interval is within a predefined range of values.

24. The impedance cardiograph as recited in claim 20 wherein said means for selecting includes:

means for measuring an interval between samples of a group which correspond to two predefined points on the second electrical signal; and

means for determining whether the interval for each group is within a predefined range of values.

25. A method of measuring cardiac activity in an animal comprising:

applying an excitation signal to the thorax of the animal;

producing a first electrical signal which varies with thoracic impedance changes of the animal;

producing a second electrical signal corresponding to a first derivative of the first electrical signal;

generating a plurality of periodic samples of the second electrical signal, the samples being divided into a number of groups with the samples in each group representing the second electrical signal during a different cardiac cycle of the animal;

identifying in each group a signal sample which occurs during a cardiac ejection interval and which corresponds to the smallest rate of change of the thoracic impedance;

aligning each group of samples of the second electrical signal about a sample in each group which occurs during a cardiac ejection interval and which corresponds to the smallest rate of change of the thoracic impedance, and ensemble averaging the aligned groups of the samples of the second electrical signal to produce a set of ensemble averaged signal samples; and

computing a cardiac performance parameter value from the ensemble averaged signal samples.

26. The method of measuring cardiac activity as recited in claim 25 further comprising selecting the groups of samples of the second electrical signal for ensemble averaging based upon whether each group of samples meets a predefined acceptance criteria.

27. The method of measuring cardiac activity as recited in claim 26 wherein selecting step includes:

measuring an interval between samples of a group which correspond to two predefined points on the second electrical signal; and

determining whether the interval for the group is within a predefined range of values.

28. The method of measuring cardiac activity as recited in claim 26 further comprising producing an electrocardiogram signal, which signal has a QRS wave during each cardiac cycle.

29. The method of measuring cardiac activity as recited in claim 28 wherein said selecting step includes:

determining whether each cardiac cycle has a duration within a first predefined range of values; and

determining whether each QRS wave has a duration within a second predefined range of values.

30. The method of measuring cardiac activity as recited in claim 28 wherein said selecting step includes:

measuring an interval between a reference point on the QRS wave and a predefined point on the second electrical signal during each cardiac cycle; and

determining whether each measured interval is within a defined range of values.

31. The method of measuring cardiac activity as recited in claim 26 wherein said selecting step includes:

producing an electrocardiogram signal having a QRS wave during each cardiac cycle;

selecting a QRS wave as a reference QRS wave;

deriving a shape fit value representing the degree to which another QRS wave matches the reference QRS wave; and

determining whether the shape fit value is within a given range of shape fit values.

32. The method of measuring cardiac activity as recited in claim 25 wherein said step of computing a cardiac performance parameter value includes calculating the stroke volume.

33. The method of measuring cardiac activity as recited in claim 25 wherein said step of computing a cardiac performance parameter value includes calculating cardiac output.

34. The method of measuring cardiac activity as recited in claim 25 further comprising evaluating a plurality of cardiac performance parameter values, and determining whether the evaluation indicates an undesirable trend in the cardiac activity of the animal.

35. An impedance cardiograph comprising:

means for applying an excitation signal to the thorax of an animal;

means, responsive to the excitation signal, for producing an electrical signal which varies with thoracic impedance changes of the animal;

means for producing an electrocardiogram signal containing a cardiac QRS wave;

means for determining a heart rate of the animal from the electrocardiogram signal;

means for measuring an interval between two predefined points within a segment of the electrical signal;

means for selecting segments of the electrical signal, a given segment being selected in response to a measurement of the interval of the segment being within a given range of values; and

means, responsive to said first means for selecting, for computing a cardiac performance parameter value from the selected segments of the electrical signal.

36. The impedance cardiograph recited in claim 35 wherein said means for selecting acquires measurements of intervals for segments from a plurality of cardiac cycles, and the given range of values is defined by a number of standard deviations from an arithmetic mean of the acquired measurements.

37. The impedance cardiograph as recited in claim 35 wherein the two predefined points correspond to half-height points on a peak in the electrical signal segment.