Microelectronic interface

• US 5,178,161 A
• Filed: 03/19/1991
• Issued: 01/12/1993
• Est. Priority Date: 09/02/1988
• Status: Expired due to Fees

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Kovacs, Gregory T. A.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US07/671,640
• Time in Patent Office: 665 Days
• Field of Search: 128/639, 128/642, 128/419 R, 128/784, 128/734, 604/20
• US Class Current: 607/115
• CPC Class Codes: A61B 17/1128 of nerves
• CPC Class Codes: A61F 2/583 Hands; Wrist joints
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

A microelectrode interface is disclosed for localizing the stimulation and recording of action potentials at a portion of a nervous system. The shapes of the electrodes are such that the number of ion flux lines actually intersecting a portion of the nervous system to be stimulated is increased or even maximized. This is accomplished by choosing microelectrodes of the shape such that they are at least as large in dimension at locations away from the other microelectrode as are locations close to the other microelectrode. The microelectrodes are on one side of a chip so that it is possible to stimulate a portion of the central nervous system by placing the microelectrodes alongside the portion. By employing microelectrodes on both sides of a chip or plate, the nervous system can be stimulated in a bipolar mode as well as the unipolar mode. The microelectrode on the back side also reduces noise. A circuit is disclosed for applying current only to one or more selected pairs of microelectrodes in an array of microelectrodes. Row and column select lines, switches and multiplexers are used for passing current only between pairs of microelectrodes at selected locations in the array for stimulating a portion of a nervous system only at selected locations.

Claims

1. A method for causing or detecting at least one action potential in a portion of a nervous system in a medium which contains ions by means of a device which comprises (a) a pair of microelectrodes supported on the same side of a carrier plate, and (b) means for applying or detecting an electrical potential deference between the pair when the portion of the nervous system is adjacent to the pair, said system and said medium being part of a human or animal body, said method comprising:

placing the pair of microelectrodes adjacent to each other and implanting said device into said body so that the pair of microelectrodes are adjacent to and alongside the portion of the nervous system and so that the portion is not between the microelectrodes; and

applying a time-varying electrical potential across the microelectrodes so that the current caused by the potential across the microelectrodes is time-varying and passes from one microelectrode through the portion and then to the other microelectrode, so that the potential difference induced in the nervous system is localized to said portion.

2. The method of claim 1, wherein said pair of microelectrodes are substantially planar, and wherein said placing step places the two electrodes so that they are substantially in the same plane, said plane being adjacent to the portion of the nervous system.

3. The method of claim 1, wherein said applying step applies a time-varying electrical potential to one microelectrode of the pair of microelectrodes and a fixed D.C. electrical potential to the other microelectrode of the pair of microelectrodes.

4. The method of claim 1, wherein the pair of microelectrodes are located on one side of the carrier plate, said device further including a third electrode on the side of the plate opposite to said one side, wherein said applying step applies a time-varying electrical potential to both microelectrodes of the pair of microelectrodes and a fixed D.C. electrical potential to the third electrode.

5. The method of claim 1, wherein the pair of microelectrodes are located on one side of the carrier plate, said device further including a third electrode on the side of the plate opposite to said one side, wherein said applying step applies a time-varying electrical potential to one microelectrode of the pair of microelectrodes, a fixed D.C. electrical potential to other microelectrode and a fixed D.C. electrical potential to the third electrode.

6. The method of claim 1, wherein the pair of microelectrodes are located on one side of the carrier plate, said carrier plate having a hole therein between the pair of microelectrodes, said method further comprising placing an axon through said hole.

7. A device for causing or detecting change in electrical potential in a portion of a nervous system in a medium which contains ions, said system and said medium being part of a human or animal body, said device comprising:

a carrier plate;

a pair of microelectrodes on one side of said plate, said microelectrodes containing no ionic substance and each having a planar surface adapted to contact said medium; and

means for applying or detecting a time-varying electrical potential difference between the planar surfaces of the pair when the portion of the nervous system is adjacent to the pair, wherein said pair of microelectrodes are located adjacent to each other so that when said electrical potential difference applying or detecting means applies a time-varying electrical potential difference between said pair when the portion of the nervous system is adjacent to the microelectrodes, the current passing between the pair is time-varying, between the planar surfaces of the microelectrodes, and substantially focused on the portion, so that a corresponding potential difference is induced in a localized portion of the nervous system.

8. The device of claim 7, further comprising:

another electrode on the side of said plate opposite to said one side, said another electrode having a planar surface adapted to contact said medium; and

means for applying a reference potential to said another electrode, so that when said electrical potential difference is applied, current is passed between said planar surfaces of the microelectrodes and of said another electrode and so that said another electrode also provides electromagnetic shielding.

9. The device of claim 8, wherein said another electrode is connected to a reference potential.

10. The device of claim 7, wherein the portion is at least one axon and wherein said carrier plate has a hole between the pair of microelectrodes, wherein the planar microelectrodes are located side-by-side but do not substantially overlap and are separated from each other by the hole, and wherein the planar microelectrodes are shaped so that each of the two microelectrodes is larger in dimension at locations away from the hole than at locations adjacent to the hole, said hole having a shape adapted for passage of the axon(s).

11. The device of claim 7, wherein the pair of microelectrodes on one side of the plate are substantially coplanar so that both microelectrodes are adapted to be placed immediately adjacent to the portion for focusing current on the portion.

12. The device of claim 7, wherein said plate comprises a semiconducting material and the microelectrodes each comprises a metal layer over said carrier plate.

13. The device of claim 12, further comprising an insulating layer covering only a portion of each of the metal layers, leaving exposed only portions of the metal layers, so that when said applying step applies an electrical potential across the microelectrodes of the pair of microelectrodes, current will pass only between the exposed portions of the metal layers through the medium.

14. A device for measuring impedance in a portion of a nervous system in a medium which contains ions, said system and said medium being part of a human or animal body, said device comprising:

a pair of microelectrodes;

means for determining impedance between the pair, including means for passing a time-varying current between the pair through the movement of ions so that when the portion of the nervous system is adjacent to the pair, at least some of the current passes through said portion, and means for detecting the electrical potential between the pair; and

means for connecting said current passing means and said detecting means to said pair.

15. The device of claim 14, wherein said detecting means includes a comparator or buffer amplifier and said connecting means connects said current passing means and said comparator or buffer amplifier to one of the microelectrodes through a common node.

16. A device for causing or detecting change in electrical potential in a medium containing ions, said device comprising:

a pair of microelectrodes suitable for use in said medium wherein each of said microelectrodes has a planar surface and are located relative to each other so that the surfaces are located side-by-side but do not substantially overlap and are separated from each other by at least a region, and so that when electrical potential is applied between them and when the microelectrodes are placed in the medium, ion sin the medium will move between the planar surface of one microelectrode and the planar surface of the other microelectrode to cause an ionic current to flow through said region between the microelectrodes; and

means for applying or detecting an electrical potential difference between the pair, wherein when said applying means applies an electrical potential difference between the pair said ionic current causes a change in electrical potential at said region, and wherein the planar surface of each of said pair of microelectrodes is shaped so that said surface is larger in dimension at locations away from the region than at locations adjacent to the region to focus the ionic current at or near the region, so that the effect of the ionic current is localized.

17. A device for causing or detecting change in electrical potential in nervous tissue located in a medium containing ions, said device comprising:

a pair of microelectrodes adapted to be placed in said medium, wherein said microelectrodes each has a substantially planar surface, wherein said planar surfaces are located adjacent to each other and in a manner so that the surfaces are located side-by-side but do not substantially overlap each other, so that when electrical potential is applied between them, ions in the medium will move between the planar surfaces of the pair of microelectrode plates causing ionic current to pass between the microelectrodes; and

means for applying or detecting an electrical potential difference between the pair, wherein the planar surface of each of said pair of microelectrodes is shaped so that each of the two planar surfaces is larger in dimension at locations away from the other planar surface than at locations adjacent to the other planar surface to focus the ionic current on locations between or adjacent to the two surfaces, so that when nervous tissue is placed in between or adjacent to the surfaces, an action potential is induced in a localized portion of the nervous tissue.

18. The device of claim 17, wherein said pair of microelectrodes are plates.

19. The device of claim 17, wherein each of said pair of microelectrodes comprises a semiconducting substrate and a layer of electrically conductive material over said substrate, and wherein a portion of a surface of the layer forms said planar surface of the microelectrode.

20. The device of claim 19, wherein each of said microelectrodes further comprises a layer of electrically insulating material covering predetermined portions of the layer of electrically conductive material, so that a surface of the uncovered portion of the electrically conductive material layer is adapted to contact the medium and defines the planar surface.

21. The device of claim 17, wherein said two planar surfaces are substantially coplanar.

22. The device of claim 17, said device further comprising insulator means for insulating portions of the microelectrodes leaving only predetermined portions of the microelectrodes exposed, so that the planar surface of each microelectrode is defined by the exposed portion or portions of the microelectrode.

23. The device of claim 17, wherein the planar surface of each microelectrode is substantially semicircular or parabolic in shape.

24. The device of claim 17, further comprising a carrier plate having an aperture therein suitable for passage of one or more axons, wherein each microelectrode comprises a layer of electrically conductive material supported by the carrier plate, the layer of each microelectrode separated from the other microelectrode layer by the aperture.