Dosage form for delivering drug to the intestine

• US 5,178,866 A
• Filed: 03/23/1990
• Issued: 01/12/1993
• Est. Priority Date: 03/23/1990
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Wright, Jeremy C., Guittard, George V.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Harrison, Robert H.
• Application Number:
  US07/498,121
• Time in Patent Office: 1,026 Days
• Field of Search: 424/468, 424/473, 424/480, 424/482, 424/471, 424/472
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means for preventing the passage of fluid through the delay means.

Claims

1. A device for delivering a drug to the intestine and colon fluid environment, wherein the device comprises:

(a) a wall that comprises a surface that faces the environment, said wall comprising a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of drug, which wall surrounds;

(b) a compartment;

(c) a drug in the compartment

(d) push means in the compartment for pushing the drug from the device;

(e) exit means in the wall for delivering the drug from the device;

(f) enteric coat means in contact with the surface of the wall that faces the environment for delaying the delivery of drug from the device, and wherein the device is characterized by;

(g) 1 weight percent to 50 weight percent of hydrophobic cellulose phthalate comprising a member selected from the group consisting of cellulose acetyl phthalate, cellulose diacetyl phthalate, cellulose triacetyl phthalate, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate, sodium cellulose acetate phthalate, cellulose ester phthalate, cellulose ether phthalate, methylcellulose phthalate, cellulose ester-ether phthalate, alkali salt of cellulose acetate phthalate, alkaline earth salt of cellulose acetate phthalate, cellulose acetate hexahydrophthalate, hydroxypropylmethylcellulose hexahydrophthalate; and

polyvinylacetate phthalate blended in the enteric coat means for substantially preventing the passage of fluid present in the environment through the enteric coat means.

2. The device for delivering the drug to the fluid environment according to claim 1, wherein the 1 weight percent to 50 weight percent of the hydrophobic cellulose phthalate means in the enteric coat means is increased and the enteric coat means is saturated with the hydrophobic cellulose phthalate means.

3. The device for delivering the drug to the fluid environment according to claim 1 wherein drug is a member selected from the group consisting of beclomethasone, beclomethasone monoester, beclomethasone diester, beclomethasone acetate, beclomethasone butyrate, beclomethasone valerate, beclomethasone propionate, beclomethasone dipropionate, and beclomethasone divalerianate.

4. The device for delivering the drug to the fluid environment according to claim 1, wherein the drug is a steroid selected from the group consisting of hydrocortisone, prednisolone, prednisolone phosphate, prednisone, prednisolone metasulphbenzoate and prednisolone sodium phosphate.

5. The improvement in a device for delivering a drug to the fluid environment according to claim 1, wherein the drug is salicylazosulphapyridine.