Apparatus for determining whether respiratory gas is present in a gaseous sample

• US 5,179,002 A
• Filed: 04/25/1991
• Issued: 01/12/1993
• Est. Priority Date: 08/13/1986
• Status: Expired due to Term

• Current Assignee: Nellcor Puritan Bennett Incorporated (Medtronic Plc)
• Original Assignee: Nellcor Incorporated (Medtronic Plc)
• Inventors: Fehder, Carl G.
• Primary Examiner(s): Johnston, Jill A.
• Application Number:
  US07/696,281
• Time in Patent Office: 628 Days
• Field of Search: 422/56-58, 422/87, 436/133, 436/163, 436/167, 436/169, 128/719, 435/25
• US Class Current: 435/25
• CPC Class Codes: A61M 2016/0413 with detectors of CO2 in exhaled gases
• CPC Class Codes: G01N 31/223 for investigating presence of specific gases or aerosols G01N31/221, G01N31/222 take precedence; actuation of fire alarm by presence of smoke or gases G08B17/10
• CPC Class Codes: Y10T 436/204998 Inorganic carbon compounds

Abstract

A method and apparatus are is disclosed for determining whether respiratory gas is present in a gaseous sample. The sample is brought into contact with an indicator which yields an indication within a diagnostically effective period of time of the presence in the sample of carbon dioxide in concentration of at least 2% while an indication of the presence of carbon dioxide or other trace acidic gas in a sample of ambient air is delayed beyond a predetermined period of time. The method and apparatus of the present invention have particular utility in determining the correct placement of an endotracheal catheter in a patient or in the direction of apnea.

Claims

1. Apparatus for determining whether a gaseous sample contains a predetermined concentration of carbon dioxide, comprising:

means for introducing the gaseous sample into an enclosure;

dry reagent detector means within the enclosure for producing a response to the presence of said predetermined concentration of carbon dioxide in the sample, said detector means comprising a carrier having a aqueous indicating composition applied thereto, said indicating composition providing an indication of the presence of said predetermined concentration of carbon dioxide in the sample within a diagnostically effective period of time when the carbon dioxide concentration in the sample is at least about 2% and providing said indication after about ten minutes when the carbon dioxide concentration in the sample is about 0.03%.

2. The apparatus of claim 1, in which said carrier comprises an inert bibulous material.

3. The apparatus of claim 1, in which said carrier comprises an inert fibrous material.

4. The apparatus of claim 1, in which said carrier comprises an inert porous material.

5. The apparatus of claim 1, in which said diagnostically effective period of time is up to about twenty seconds.

6. The apparatus of claim 5, in which said diagnostically effective period of time is from about two to about ten seconds.

7. The apparatus of claim 1, in which said indication is visually observable.

8. The apparatus of claim 1, in which said detector means is substantially non-fluid.

9. The apparatus of claim 1, in which said indicating composition comprises predetermined amounts of a base and a hygroscopic material.

10. The apparatus of claim 9, in which the pH of said base is in the range of from about 9.0 to about 10.2.

11. The apparatus of claim 1, in which said indicating composition comprises carbonic anhydrase.

12. The apparatus of claim 1, in which said detector means comprises a pH sensitive substance.

13. The apparatus of claim 1, in which said indicating composition consists essentially of a chromogenic material and a hygroscopic, water-miscible liquid.

14. The apparatus of claim 13, in which said indicating composition comprises an aqueous alkaline solution.

15. The apparatus of claim 14, in which said chromogenic material comprises a chromogenic pH indicator.

16. The apparatus of claim 15, in which a predetermined relationship exists between the pH of said indicating composition and the pK of said chromogenic pH indicator.

17. The apparatus of claim 16, in which said chromogenic pH indicator has a pK in said solution which is lower by about 0.5-2.8 pH units than the pH of said aqueous alkaline solution.

18. The apparatus of claim 17, in which said chromogenic pH indicator has a pK in solution which is lower by about 1.0-1.5 pH units than the pH of said aqueous alkaline solution.

19. The apparatus of claim 16, in which said aqueous alkaline solution is a solution of calcium hydroxide and said chromogenic pH indicator is selected from the group comprising metacresol purple and chromogenic pH indicators having pK values substantially the same as metacresol purple.

20. The apparatus of claim 1, in which said carrier comprises cellulose.

21. The apparatus of claim 1, comprising means for protecting said detector means from ambient air until no more than about fifteen minutes prior to exposure to said sample.

22. An element for use in detecting the presence of respiratory concentrations of carbon dioxide in a gaseous sample, comprising:

a substrate; and

a dried non-volatile chemical composition carried by said substrate, said composition providing an indication within a predetermined period of time of the presence of a respiratory concentration of carbon dioxide in the sample and providing said indication after about ten minutes when the concentration of carbon dioxide in the sample is substantially less than said respiratory concentration.

23. A device for detecting the presence of a predetermined concentration of carbon dioxide in a gaseous sample comprising a non-liquid detector element having a non-volatile chemical composition the pH of which changes in the presence of said predetermined concentration and means responsive to said change in pH for providing an indication within a predetermined period of time of the presence of said predetermined concentration of carbon dioxide in the sample and providing said indication after about ten minutes when the concentration of carbon dioxide in the sample is substantially less than said respiratory concentration.

24. Apparatus for determining whether a gaseous sample contains a predetermined concentration of carbon dioxide, comprising:

means for introducing the gaseous sample into an enclosure;

detector means within the enclosure for responding to the presence of the predetermined concentration of carbon dioxide, said detector means comprising a carrier to which a non-volatile indicating composition has been applied, said indicating composition providing a first response within a diagnostically effective period of time when the carbon dioxide concentration in the sample is at least about 2% but not providing said first response for more than about ten minutes when the carbon dioxide concentration in the sample is about 0.03%, and providing a second response within said diagnostically effective period of time when the sample is replaced with ambient air.

25. The apparatus of claim 24, in which said first response consists of a first observable color change and said second response consists of a second observable color change.