Apparatus for detecting a change of viscosity by measuring a relative slip, in particular for detecting the coagulation rate of blood

• US 5,181,415 A
• Filed: 07/18/1991
• Issued: 01/26/1993
• Est. Priority Date: 07/20/1990
• Status: Expired due to Fees

• Current Assignee: Diagnostica Stago (Stago International)
• Original Assignee: Serbio Co.
• Inventors: Esvan, Daniel, Roisin, Jean P.
• Primary Examiner(s): Williams, Hezron E.
• Assistant Examiner(s): ROSKOS, JOSEPH
• Application Number:
  US07/732,388
• Time in Patent Office: 558 Days
• Field of Search: 73/64.1, 73/59, 422/73, 436/69
• US Class Current: 73/54.28
• CPC Class Codes: G01N 11/14 by using rotary bodies, e.g. vane G01N11/16 takes precedence
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/56

Abstract

An apparatus is disclosed for detecting a change of viscosity of a blood sample in time, comprising a drive element and a driven element having respective facing walls which define therebetween a chamber of calibrated volume adapted to receive a blood sample, the driven element being driven in relative rotation by the drive element with a relative slip which depends on the viscosity of the blood which provides coupling between the two elements and means for measuring the relative change of slip.

Claims

1. An apparatus for detecting a change of viscosity of a fluid medium in time, comprising a drive element and a driven element having respective facing walls which define therebetween a chamber of calibrated volume adapted to receive a fluid sample, the driven element being driven in relative rotation by the drive element with a relative slip which depends on the viscosity of the fluid which provides coupling between the two elements and means for measuring the relative change of slip, wherein said measuring means comprise a magnetic means cooperating with a block of magnetic material for immobilizing the driven element until the moment when the coagulation causes the facing walls to adhere together with sufficient force to cause said driven element to be driven.

2. The apparatus as claimed in claim 1, comprising means for determining the time when the relative slip becomes less than a predetermined threshold.

3. The apparatus as claimed in claim 1 for measuring the coagulation rate of a blood sample in contact with an appropriate reagent, wherein said reagent is deposited in the form of a uniform layer on at least one of the facing walls of the drive and driven elements.

4. The apparatus as claimed in claim 1, wherein the driven element forms a lid which caps the drive element, the arrangement being such that a possible excess of liquid with respect to the calibrated volume is driven outside.

5. The apparatus as claimed in claim 1, wherein said elements are removable with respect to each other and an electric contact is formed at a moment when they are placed in a position which defines a predetermined volume, said electric contact forming part of a circuit generating a blip for starting a time measurement, means for detecting a beginning of driving of the driven element delivering a blip when the time measurement is ended.

6. The apparatus as claimed in claim 1, wherein said magnetic element is a permanent magnet.

7. The apparatus as claimed in claim 1, wherein said drive element forms with the driven element a disposable assembly which is removably assembled to said apparatus.