Method and apparatus for the measurement of atrial pressure

• US 5,181,517 A
• Filed: 06/25/1991
• Issued: 01/26/1993
• Est. Priority Date: 09/18/1989
• Status: Expired due to Term

• Current Assignee: The Research Foundation for The State University of New York (State University of New York)
• Original Assignee: State University of New York
• Inventors: Hickey, Donald D.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US07/717,854
• Time in Patent Office: 581 Days
• Field of Search: 128/672, 128/675, 128/687, 128/780
• US Class Current: 600/486
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/037 Measuring oesophageal pressure
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

Non-invasive apparatus and method for obtaining a quantitative determination of mean left atrial pressure or otherwise obtaining a quantitative determination of a left atrial pressure value. A balloon is inserted by means of a catheter into the esophagus and positioned adjacent the left atrium. The balloon is gradually inflated. A tracing of mean balloon pressure is obtained as the balloon is inflated. In addition, a tracing of balloon pressure on a steady baseline and with low frequency oscillations due to respiration filtered out is obtained whereby the tracing represents balloon pressure oscillations effected by left atrial pressure. In accordance with the oscillometric principle the mean balloon pressure is measured at the time when the amplitude of the balloon pressure oscillations effected by the left atrial pressure is at a peak. This mean balloon pressure is indicative of approximate mean left atrial pressure. Mean left atrial transmural pressure may be determined by subtracting therefrom the mean esophageal pressure as measured at a position in the esophagus where it is unaffected by the heart.

Claims

1. Apparatus comprising a catheter means which includes a balloon and is insertable into an esophagus for positioning said balloon adjacent the left atrium, means for inflating said balloon, and means for measuring the balloon pressure when the amplitude of balloon pressure oscillations effected by the left atrial pressure when said balloon is adjacent the left atrium is at a peak.

2. Apparatus according to claim 1 further comprising means for sensing position of said balloon adjacent the left atrium.

3. Apparatus according to claim 2 wherein said balloon position sensing means comprises means for filtering balloon pressure to remove oscillations thereof having a frequency less than about 0.8 Hertz whereby oscillations thereof which are passed may be compared with a skin electrocardiogram.

4. Apparatus according to claim 2 wherein said balloon position sensing means comprises electrode means on said catheter means adjacent said balloon for obtaining an esophageal electrocardiogram of the left atrium.

5. Apparatus according to claim 2 wherein said balloon position sensing means comprises another balloon positioned on said catheter means so that the distance between said balloons is equal to about the distance in an adult between the esophagogastric junction and the left atrium.

6. Apparatus according to claim 1 wherein said balloon pressure measuring means comprises another catheter means which includes another balloon and is insertable into an esophagus for positioning said another balloon intermediate the left atrium and the entrance of said another catheter to the esophagus, a differential pressure transducer means, and means for transmitting the pressures in said balloons to respectively opposite sides of said differential transducer means whereby respiration effected pressure oscillations may be cancelled and a signal of balloon pressure oscillations effected by left atrial pressure may be outputted.

7. Apparatus according to claim 1 further comprising means for exhausting from said balloon for slowing rapid pressure rises of said balloon.

8. Apparatus according to claim 1 wherein said balloon has an inflated diameter which is between about 0.9 and 1.5 cm.

9. Apparatus according to claim 1 wherein said balloon has an inflated length which is between about 3 and 4 cm.

10. Apparatus according to claim 1 wherein said balloon has an inflated diameter of about 1 cm.

11. Apparatus for determining mean left atrial pressure comprising a catheter means which includes a balloon and is insertable into an esophagus for positioning said balloon adjacent the left atrium, means for gradually inflating said balloon whereby left atrial pressure and respiratory waves effect balloon pressure oscillations as said balloon is inflated while adjacent the left atrium, means for measuring mean balloon pressure, and means for filtering the balloon pressure to pass oscillations effected by the left atrial pressure whereby the mean left atrial pressure may be determined in accordance with the oscillometric principle by reference to the mean balloon pressure when the amplitude of the oscillations effected by the left atrial pressure is at a peak.

12. Apparatus according to claim 11 further comprising means for sensing position of said balloon adjacent the left atrium.

13. Apparatus according to claim 11 wherein said mean balloon pressure measuring means comprises means for filtering the balloon pressure to remove oscillations therefrom which are greater than about 0.8 Hertz.

14. Apparatus according to claim 11 wherein said filtering means comprises a differential pressure transducer, means for applying the balloon pressure to one side of said transducer, and means for applying balloon pressure oscillations having a frequency less than about 0.8 Hertz to the other side of said transducer.

15. Apparatus for determining mean left atrial pressure comprising a catheter means which includes a balloon and is insertable into an esophagus for positioning said balloon adjacent the left atrium, means for sensing position of said balloon adjacent the left atrium, means for gradually inflating said balloon whereby left atrial pressure and respiratory pressure waves effect balloon pressure oscillations as the balloon is inflated while adjacent the left atrium, transducer means for converting the balloon pressure to an electrical signal, means for converting said electrical signal to an electrical signal of mean balloon pressure, a differential transducer means having a diaphragm for application of pressures on opposite sides thereof for converting the difference in the applied pressures to an electrical signal, means for applying balloon pressure to one side of said diaphragm, means for applying balloon pressure oscillations having a frequency less than about 0.8 Hertz to the other side of said diaphragm whereby balloon pressure oscillations having a frequency greater than about 0.8 Hertz effected by the left atrial pressure are converted to an electrical signal having a steady baseline by the differential transducer means and whereby the mean left atrial pressure may be determined in accordance with the oscillometric principle by reference to the mean balloon pressure when the amplitude of said balloon pressure oscillations effected by the left atrial pressure is at a peak.

16. Apparatus comprising a catheter means which includes a balloon and is insertable into an esophagus for positioning said balloon adjacent the left atrium, means for inflating said balloon whereby left atrial pressure and respiratory waves effect balloon pressure oscillations as said balloon is inflated while adjacent the left atrium, and means for filtering the balloon pressure to remove oscillations thereof effected by respiratory waves whereby oscillations effected by the left atrial pressure may be passed free of the effects of respiratory waves.

17. Apparatus according to claim 16 further comprising means for measuring the mean balloon pressure when the amplitude of balloon pressure oscillations effected by the left atrial pressure is at a peak.

18. Apparatus comprising a catheter means which includes a balloon and is insertable into an esophagus for positioning said balloon adjacent the left atrium, means for inflating said balloon, means for filtering the balloon pressure to remove oscillations thereof having a frequency less than about 0.8 Hertz whereby a wave form of oscillations effected by left atrial pressure free of oscillations having a frequency less than about 0.8 Hertz may be obtained, and means for measuring the means balloon pressure when the amplitude of balloon pressure oscillations effected by the left atrial pressure is at a peak.

19. A method of determining means left atrial pressure comprising the steps of:

a. inserting a catheter including a balloon into an esophagus of a subject;

b. positioning the balloon adjacent the left atrium;

c. inflating the balloon; and

d. measuring the balloon pressure when the amplitude of balloon pressure oscillations having a frequency greater than about 0.8 Hertz is at a peak.

20. A method according to claim 19 comprising gradually inflating the balloon at a constant rate, said peak oscillations being indicative of resonating of the balloon pressure as affected by the mean left atrial pressure in accordance with the oscillometric principle.

21. A method according to claim 19 wherein the step of positioning the balloon comprises moving the balloon along the esophagus with an electrode adjacent the balloon and connected to an electrocardiograph to obtain an esophageal electrocardiogram, and fixing the balloon position when the electrocardiogram indicates left atrial proximity.

22. A method according to claim 19 wherein step (d) comprises converting the balloon pressure to an electrical signal of mean balloon pressure and further comprises filtering the balloon pressure to remove oscillations thereof having a frequency less than about 0.8 Hertz whereby a wave form of oscillations having a frequency greater than said about 0.8 Hertz on a steady baseline may be obtained.

23. A method according to claim 19 further comprising selecting the balloon to have an inflated diameter which is between about 0.9 and 1.5 cm.

24. A method according to claim 19 further comprising exhausting pressure from the balloon to slow rapid balloon pressure rises.

25. A method according to claim 19 further comprising positioning the subject in a position wherein the heart weight does not bear on the esophagus for obtaining the measurement.

26. A method according to claim 19 further comprising subtracting mean esophageal pressure, measured at least about 3 cm. above the heart, from the mean left atrial pressure determination to obtain a determination of the mean left atrial transmural pressure.

27. A method according to claim 19 further comprising subtracting mean esophageal pressure from said balloon pressure to correct for the effects of positive end expiratory pressure for patients connected to respirators.

28. A method according to claim 19 comprising supplying a liquid to the balloon for inflation thereof and pressurizing the liquid in the balloon.

29. A method of determining means left atrial pressure comprising the steps of:

a. inserting a catheter including a balloon into an esophagus;

b. positioning the balloon adjacent the left atrium;

c. inflating the balloon;

d. filtering the balloon pressure to remove oscillations thereof having a frequency less than about 0.8 Hertz whereby a wave form of oscillations effected by left atrial pressure free of oscillations having a frequency less than about 0.8 Hertz may be obtained; and

e. measuring means balloon pressure when the amplitude of said filtered balloon pressure oscillations is at a peak to obtain a determination of means left atrial pressure.

30. A method of determining mean left atrial transmural pressure comprising the steps of:

inserting a catheter including a balloon into an esophagus;

b. positioning the balloon adjacent the left atrium;

c. inflating the balloon;

d. measuring the mean balloon pressure when the amplitude of balloon pressure oscillations having a frequency greater than about 0.8 Hertz is at a peak;

e. measuring mean balloon pressure when the amplitude of said balloon pressure oscillations is at a peak to obtain a determination of mean left atrial pressure;

f. determining mean esophageal pressure as unaffected by the heart; and

g. subtracting said mean esophageal pressure from said means left atrial pressure.