Multiple aliquot device for distributing a liquid solution into a well
First Claim
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1. A device for dividing a sample into aliquots without air entrapment and for retention of aliquots therein, comprising:
- a sample distribution element comprising an upper surface and a lower surface substantially parallel to each other, means for containing and/or guiding said sample associated with said upper surface, and at least one well disposed between said upper and lower surfaces wherein said well comprises an upper mouth opening that forms a substantially sharp junction with said upper surface, a lower mouth opening in said lower surface, a sidewall connecting said upper mouth opening with said lower mouth opening, and a sidewall bottom surface associated with said lower mouth opening;
and an outer-base element associated with a portion of said sample distribution element comprising a bottom with an inner surface and at least one well bottom raised from said inner surface;
wherein said sidewall bottom surface of said well of said sample distribution element and said well bottom of said outer-base element are substantially parallel to each other and form a spaced mean stop allow the escape of air.
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Abstract
The present invention is a device which allows for receiving, distributing and storing a sample into numerous aliquots of small volume without air entrapment and with retention of aliquots when the device is manipulated. The device allows for the treatment of any or all of the aliquots with the same or different reagents and/or other chemical additives. The device comprises a housing for containing a body for guiding a sample into a plurality of wells without the need for pipetting aids, without multiple manipulations, without the retention of air and for retaining sample in the wells.
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Citations
27 Claims
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1. A device for dividing a sample into aliquots without air entrapment and for retention of aliquots therein, comprising:
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a sample distribution element comprising an upper surface and a lower surface substantially parallel to each other, means for containing and/or guiding said sample associated with said upper surface, and at least one well disposed between said upper and lower surfaces wherein said well comprises an upper mouth opening that forms a substantially sharp junction with said upper surface, a lower mouth opening in said lower surface, a sidewall connecting said upper mouth opening with said lower mouth opening, and a sidewall bottom surface associated with said lower mouth opening; and an outer-base element associated with a portion of said sample distribution element comprising a bottom with an inner surface and at least one well bottom raised from said inner surface; wherein said sidewall bottom surface of said well of said sample distribution element and said well bottom of said outer-base element are substantially parallel to each other and form a spaced mean stop allow the escape of air. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification