NMR measuring method and measuring apparatus for tissue of a living body

• US 5,183,045 A
• Filed: 04/16/1990
• Issued: 02/02/1993
• Est. Priority Date: 06/17/1988
• Status: Expired due to Fees

• Current Assignee: Otsuka Electronics Co., Ltd. (Otsuka Holdings Company Limited)
• Original Assignee: Otsuka Electric Co. Ltd. (KAGA Electronics Company Limited)
• Inventors: Oka, Koichi, Takamura, Susumu, Toda, Harumi, Kanki, Ichiro, Negayama, Naomi, Yoshida, Minoru, Nakamura, Takashi, Okawauchi, Makoto, Imoto, Toshiyuki
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Pfaffle, Krista M.
• Application Number:
  US07/460,336
• Time in Patent Office: 1,023 Days
• Field of Search: 128/653.2, 128/653.5, 324/300, 324/307, 324/309, 324/318, 324/321, 436/173
• US Class Current: 600/422
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/30 Sample handling arrangements, e.g. sample cells, spinning mechanisms
• CPC Class Codes: G01R 33/34007 Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system
• CPC Class Codes: G01R 33/34053 Solenoid coils; Toroidal coils
• CPC Class Codes: G01R 33/341 comprising surface coils
• CPC Class Codes: G01R 33/465 applied to biological material, e.g. in vitro testing
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

There is carried out an NMR measurement in which a receiver coil (7) for receiving an NMR free induction signal comes in contact with or in close vicinity to one side of tissue of a living body (1) immersed in a perfusion solution (4), while a portion or whole body of the receiver coil (7) is so held as not to come in contact with the perfusion solution (4). According to this measuring method, since a portion or whole body of the receiver coil (7) does not come in contact with the perfusion solution (4), the receiver coil (7) is hardly subject to the electromagnetic influence of changes in the perfusion solution (4). This prevents the free induction signal from being embedded in noise, assuring measurement with high sensitivity. Even for a large-size internal organ, only a signal from an area presenting a uniform magnetic field may be acquired, since the measurement is carried out with the receiver coil (7) coming in contact with or in close vicinity to one side of the internal organ. Thus, a high-resolution free induction signal may be acquired.

Claims

1. An NMR measuring method for tissue of a living body immersed in a perfusion solution comprising

(1) immersing the tissue of the living body in the perfusion solution,

(2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue,

(3) holding the receiver coil to prevent contact with the perfusion solution, and

(4) obtaining an NMR measurement.

2. An NMR measuring method for tissue of a living body immersed in a perfusion solution comprising

(1) immersing the tissue of the living body in the perfusion solution,

(2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue,

(3) holding the receiver coil so that only a part of the receiver coil comes in contact with the perfusion solution, and

(4) obtaining an NMR measuring.

3. An NMR measuring apparatus for tissue of a living body immersed in a perfusion solution comprising

a perfusion cell which receives a perfusion solution,

a means for generating an NMR free induction signal,

a receiver coil for receiving the NMR free induction signal connection to said means for generating an NMR free induction signal.

a material, which does not exert a negative influence upon a transmission of the free induction signal, partially or completely surrounding the receiver coil,

a measuring device coupled to the receiver coil,

wherein the receiver coil does not come into contact with the perfusion solution, and the receiver coil is placed in contact with or in close vicinity to only one side of the tissue of the living body.

4. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material forms a container which completely surrounds the receiver coil.

5. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material forms a container which partially surrounds the receiver coil.

6. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the inside of the receiver coil is filled with a resin.

7. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material is a container made of a resin selected from the group consisting of Juracon resin, polytetrafluorinated ethylene resin, and acrylic resin.

8. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the material is a resin.

9. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the receiver coil is molded with a resin.

10. An NMR measuring apparatus for tissue of a living body as set forth in claim 3, wherein the perfusion solution is selected from the group consisting of phosphoric acid and physiological saline solution.

11. An NMR measuring method for tissue of a living body immersed in a perfusion solution or by a flowing perfusion solution comprising:

(1) immersing the tissue of the living body in the perfusion solution or by the flowing perfusion solution and changing the concentration of the perfusion solution or the flowing perfusion solution over time,

(2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue,

(3) holding the receiver coil to prevent contact with the perfusion solution or the flowing perfusion, and

(4) obtaining an NMR measurement.

12. An NMR measuring method for tissue of a living body immersed in a perfusion solution or by a flowing perfusion solution comprising:

(1) immersing the tissue of the living body in the perfusion solution or by the flowing perfusion solution and changing the concentration of the perfusion solution or the flowing perfusion solution over time;

(2) placing a receiver coil for receiving an NMR free induction signal in contact with or in close vicinity to only one side of the tissue,

(3) holding the receiver coil so that only a part of the receiver coil comes in contact with the perfusion solution or the flowing perfusion solution, and

(4) obtaining an NMR measurement.