Conjugate of adriamycin and cyclodextrin
First Claim
Patent Images
1. A compound of formula (I) ##STR7## wherein R is a divalent hydrocarbon group selected from the group consisting of C1 -C6 alkylene, --C═
- C--, C5 -C7 cycloalkylene, 1,2-phenylene and 2,3- and 1,8-naphthalene,CD is a cyclodextrin residue,m is 1 to 8, andn is 0 to 8.
1 Assignment
0 Petitions
Accused Products
Abstract
Adriamycin derivatives represented by formula (I) ##STR1## wherein R denotes a divalent hydrocarbon group,
CD denotes a cyclodextrin residue,
m is 1 to 8, and
n is 0 to 8.
The compounds exhibit excellent anti-cancer activity over a wide administration range, have low toxicity and sustained release, and maintain activity for a long period of time; thus, they are quite useful as an anti-cancer agent.
-
Citations
8 Claims
-
1. A compound of formula (I) ##STR7## wherein R is a divalent hydrocarbon group selected from the group consisting of C1 -C6 alkylene, --C═
- C--, C5 -C7 cycloalkylene, 1,2-phenylene and 2,3- and 1,8-naphthalene,
CD is a cyclodextrin residue, m is 1 to 8, and n is 0 to 8. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- C--, C5 -C7 cycloalkylene, 1,2-phenylene and 2,3- and 1,8-naphthalene,
Specification