Method of packaging freeze dried vaccines in syringes and plug for implementing the method
First Claim
1. Method of packaging freeze dried vaccine in a bypass syringe in which sterilized syringes are disposed in rows in an aseptic dispensing machine, doses of a solution or suspension to be freeze dried are introduced into said syringes, a temporary plug is inserted in the same machine into the mouth of said syringe body in a position allowing communication between the interior of said syringe body and the exterior, said syringes are introduced into a freeze drying machine, the vaccine is freeze dried, at the end of the freeze drying cycle said temporary plug is depressed in a controlled atmosphere in said freeze drying machine into a hermetic sealing position, said syringes are transferred into an aseptic dispensing machine, said temporary plug is removed, an intermediate piston-plug is fitted, the dose of solvent is introduced and an end terminal piston-plug is fitted.
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Accused Products
Abstract
In a method of packaging freeze dried vaccine in a bypass syringe sterilized syringes are disposed in rows in an aseptic dispensing machine. Doses of a solution or suspension to be freeze dried are introduced into the syringes. A temporary plug is inserted in the same machine into the mouth of the syringe body in a position allowing communication between the interior of the syringe body and the exterior. The syringes are introduced into a freeze drying machine. The vaccine is freeze dried. At the end of the freeze drying cycle the temporary plug is depressed in a controlled atmosphere in the freeze drying machine into a hermetic sealing position. The syringes are transferred into an aseptic dispensing machine. The temporary plug is removed. An intermediate piston-plug is fitted. The dose of solvent is introduced and an end piston-plug is fitted.
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Citations
9 Claims
- 1. Method of packaging freeze dried vaccine in a bypass syringe in which sterilized syringes are disposed in rows in an aseptic dispensing machine, doses of a solution or suspension to be freeze dried are introduced into said syringes, a temporary plug is inserted in the same machine into the mouth of said syringe body in a position allowing communication between the interior of said syringe body and the exterior, said syringes are introduced into a freeze drying machine, the vaccine is freeze dried, at the end of the freeze drying cycle said temporary plug is depressed in a controlled atmosphere in said freeze drying machine into a hermetic sealing position, said syringes are transferred into an aseptic dispensing machine, said temporary plug is removed, an intermediate piston-plug is fitted, the dose of solvent is introduced and an end terminal piston-plug is fitted.
- 5. Temporary plug for implementing a method of packaging freeze dried vaccine in a bypass syringe in which sterilized syringes are disposed in rows in an aseptic dispensing machine, doses of a solution or suspension to be freeze dried are introduced into said syringes, a temporary plug is inserted in the same machine into the mouth of said syringe body in a position allowing communication between the interior of said syringe body and the exterior, said syringes are introduced into a freeze drying machine, the vaccine is freeze dried, at the end of the freeze drying cycle said temporary plug is depressed in a controlled atmosphere in said freeze drying machine into a hermetic sealing position, said syringes are transferred into an aseptic dispensing machine, said temporary plug is removed, an intermediate piston-plug is fitted, the dose of solvent is introduced and an end terminal piston-plug is fitted, said temporary plug comprising a first part adapted to enter at least partially into said syringe body and said passages enabling communication between the interior of said syringe and the exterior environment, a second part adapted to be inserted into said syringe body in a second insertion position of said temporary plug to seal hermetically said syringe body, and a third part adapted to project to the outside in any position of said temporary plug to enable grasping of said temporary plug to remove it from said syringe body.
Specification