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Method of packaging freeze dried vaccines in syringes and plug for implementing the method

  • US 5,184,450 A
  • Filed: 02/18/1992
  • Issued: 02/09/1993
  • Est. Priority Date: 02/15/1991
  • Status: Expired due to Term
First Claim
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1. Method of packaging freeze dried vaccine in a bypass syringe in which sterilized syringes are disposed in rows in an aseptic dispensing machine, doses of a solution or suspension to be freeze dried are introduced into said syringes, a temporary plug is inserted in the same machine into the mouth of said syringe body in a position allowing communication between the interior of said syringe body and the exterior, said syringes are introduced into a freeze drying machine, the vaccine is freeze dried, at the end of the freeze drying cycle said temporary plug is depressed in a controlled atmosphere in said freeze drying machine into a hermetic sealing position, said syringes are transferred into an aseptic dispensing machine, said temporary plug is removed, an intermediate piston-plug is fitted, the dose of solvent is introduced and an end terminal piston-plug is fitted.

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