Apparatus and method for detecting abnormal cardiac rhythms using evoked potential measurements in an arrhythmia control system

• US 5,184,615 A
• Filed: 03/08/1991
• Issued: 02/09/1993
• Est. Priority Date: 03/08/1991
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories Incorporated)
• Inventors: Steinhaus, Bruce M., Nappholz, Tibor A., Dawson, Albert K., Lu, Richard M. T.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US07/667,316
• Time in Patent Office: 704 Days
• Field of Search: 128/419 D, 128/419 PG
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3716 with reduction of residual polarisation effects

Abstract

In an implantable antiarryhythmia pacemaker, an automatic cardiac arrhythmia detection and classification monitoring apparatus and method for measuring stimulated intracardiac electrogram potentials, deriving therefrom a paced depolarization integral (PDI), analyzing time-based changes in the PDI, detecting and classifying harmful cardiac rhythms while distinguishing harmful from benign tachycardias, and automatically establishing and initiating an appropriate therapy, if necessary, to revert the arrhythmia condition.

Claims

1. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter, and

means responsive to said detecting means for classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles, and for classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles.

2. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 1, wherein said arrhythmia detection control parameter is a paced depolarization integral, said pathological tachycardia is characterized generally by an increasing paced depolarization integral, and said benign physiological tachycardia is characterized generally by a paced depolarization integral which decreases or remains unchanged.

3. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 1, further comprising means responsive to classification of the cardiac rhythm as a pathological tachycardia by said classifying means for controlling said generating means to operate in an antitachycardia pacing mode.

4. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter,

means responsive to said detecting means for classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles, and for classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles, and

means responsive to classification of the cardiac rhythm as a pathological tachycardia by said classifying means for controlling said generating means to operate in a dual-chamber antitachycardia pacing mode in which atrial and ventricular pacing pulses are generated and delivered in a series of pulse trains with each train consisting of a series of pacing pulses delivered in rapid succession in an alternating sequence to the ventricle and to the atrium.

5. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter,

means responsive to said detecting means for classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles, and for classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles,

means responsive to said detecting means for measuring short-term uniformity of said arrhythmia detection control parameter, and

means for classifying a cardiac rhythm as fibrillation when said arrhythmia detection control parameter changes in a third predetermined direction and magnitude within a predetermined number of cardiac cycles and said short-term uniformity measurement changes in a fourth predetermined directions and magnitude within a predetermined number of cardiac cycles,

6. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 5, wherein said arrhythmia detection control parameter is a paced depolarization integral and said fibrillation is characterized in general by a decreasing paced depolarization integral occurring simultaneously with a decreasing short-term uniformity of paced depolarization time samples.

7. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 5, further comprising:

means for generating defibrillation shocks; and

means responsive to the classification of a cardiac rhythm as fibrillation by said classifying means for controlling said defibrillation generating means to generate shocks.

8. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter,

means for sensing heartbeats,

means responsive to said heartbeat sensing means for determining a heart rate, and

means responsive to said detecting means and said heart rate determining means for classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than a predetermined tachycardia rate, and for classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than said tachycardia rate.

9. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 8, wherein said arrhythmia detection control parameter is a paced depolarization integral, said pathological tachycardia is characterized generally by an increasing paced depolarization integral, and said benign physiological tachycardia is characterized generally by a paced depolarization integral which decreases or remains unchanged.

10. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 8, further comprising means responsive to classification of the cardiac rhythm as a pathological tachycardia by said classifying means for controlling said generating means to operate in an antitachycardia pacing mode.

11. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter,

means for sensing heartbeats,

means responsive to said heartbeat sensing means for determining a heart rate,

means responsive to said detecting means and said heart rate determining means for classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than a predetermined tachycardia rate, and for classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than said tachycardia rate, and

means responsive to classification of the cardiac rhythm as a pathological tachycardia by said classifying means for controlling said generating means to operate in an antitachycardia pacing mode,

wherein said antiarrhythmia pacing device operates in a dual-chamber antitachycardia pacing mode in which atrial and ventricular pacing pulses are generated and delivered in a series of pulse trains with each train consisting of a series of pacing pulses delivered in rapid succession in an alternating sequence to the ventricle and to the atrium.

12. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter,

means for sensing heartbeats,

means responsive to said heartbeat sensing means for determining a heart rate,

means responsive to said detecting means and said heart rate determining means for classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than a predetermined tachycardia rate, and for classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than said tachycardia rate,

means responsive to said detecting means for measuring short-term uniformity of said arrhythmia detection control parameter, and

means for classifying a cardiac rhythm as fibrillation when said heart rate is faster than a predetermined fibrillation rate, said arrhythmia detection control parameter changes in a third predetermined direction and magnitude within a predetermined number of cardiac cycles, and said short-term uniformity measurement changes in a fourth predetermined direction and magnitude within a predetermined number of cardiac cycles.

13. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 12, wherein said arrhythmia control parameter is a paced depolarization integral and said fibrillation is characterized in general by a decreasing paced depolarization integral occurring simultaneously with a decreasing short-term uniformity of paced depolarization time samples.

14. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 12, further comprising:

means for generating defibrillation shocks and

means responsive to the classification of a cardiac rhythm as fibrillation by said classifying means for controlling said defibrillation generating means to generate shocks.

15. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an anti-arrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses,

measuring an evoked potential of the patient'"'"'s heart that is responsive to said generated stimulation pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter, and

classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles, and classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles.

16. A method of detecting and reverting cardiac arrhythmias in accordance with claim 15, wherein said arrhythmia detection control parameter is a paced depolarization integral, said pathological tachycardia is characterized generally by an increasing paced depolarization integral, and said benign physiological tachycardia is characterized generally by a paced depolarization integral which decreases or remains unchanged.

17. A method of detecting and reverting cardiac arrhythmias in accordance with claim 15, further comprising the step of controlling said generating means to operate in an antitachycardia pacing mode in response to classifying a cardiac rhythm as a pathological tachycardia.

18. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an antiarrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses.

measuring an evoked potential of the patient'"'"'s heart that is responsive to said generated stimulation pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter,

classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles, and classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles,

controlling said generating means to operate in a dual-chamber antitachycardia pacing mode in response to classifying a cardiac rhythm as a pathological tachycardia, and

generating and delivering a series of pulse trains in the heart'"'"'s atrium and in the heart'"'"'s ventricle, with each train consisting of a series of pacing pulses delivered in rapid succession in an alternating sequence to the ventricle and to the atrium.

19. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an antiarrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses,

measuring an evoked potential of the patient'"'"'s heart that is responsive to said generated stimulation pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter,

classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles, and classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles,

measuring short-term uniformity of said arrhythmia detection control parameter, and

classifying a cardiac rhythm as fibrillation when said arrhythmia detection control parameter changes in a third predetermined direction and magnitude within a predetermined number of cardiac cycles and said short-term uniformity measurement changes in a fourth predetermined direction and magnitude within a predetermined number of cardiac cycles.

20. A method of detecting and reverting cardiac arrhythmias in accordance with claim 19, wherein said arrhythmia control parameter is a paced depolarization integral and said fibrillation is characterized in general by a decreasing paced depolarization integral occurring simultaneously with a decreasing short-term uniformity of paced depolarization time samples.

21. A method of detecting and reverting cardiac arrhythmias in accordance with claim 19, further comprising the steps of:

generating defibrillation shocks; and

controlling said defibrillation generating step to generate shocks in response to classification of a cardiac rhythm as fibrillation in said classifying step.

22. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an anti-arrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses,

measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter,

sensing heartbeats,

timing the interval between sensed heartbeats to determine a heart rate, and

classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than a predetermined tachycardia rate, and classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than said tachycardia rate.

23. A method of detecting and reverting cardiac arrhythmias in accordance with claim 22, wherein said arrhythmia detection control parameter is a paced depolarization integral, said pathological tachycardia is characterized generally by an increasing paced depolarization integral, and said benign physiological tachycardia is characterized generally by a paced depolarization integral which decreases or remains unchanged.

24. A method of detecting and reverting cardiac arrhythmias in accordance with claim 22, further comprising the step of controlling said generating means to operating in an antitachycardia pacing mode in response to classifying a cardiac rhythm as a pathological tachycardia.

25. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an antiarrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses,

measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulate pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter,

sensing heartbeats,

timing the interval between sensed heartbeats to determine a heart rate,

classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than a predetermined tachycardia rate, and classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than said tachycardia rate,

controlling said generating means to operate in a dual-chamber antitachycardia pacing mode in response to classifying a cardiac rhythm as a pathological tachycardia, and

generating and delivering a series of pulse trains in the heart'"'"'s atrium and in the heart'"'"'s ventricle, with each train consisting of a series of pacing pulses delivered in rapid succession in an alternating sequence to the ventricle and to the atrium.

26. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an antiarrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses,

measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter,

sensing heartbeats,

timing the interval between sensed heartbeats to determine a heart rate,

classifying a cardiac rhythm as a pathological tachycardia when said arrhythmia detection control parameter changes in a first predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than a predetermined tachycardia rate, and classifying a cardiac rhythm as a benign physiological tachycardia when said arrhythmia detection control parameter changes in a second predetermined direction and magnitude within a predetermined number of cardiac cycles and said heart rate is faster than said tachycardia rate,

measuring short-term uniformity of said arrhythmia detection control parameter, and

classifying a cardiac rhythm as fibrillation when said heart rate is faster than a predetermined fibrillation rate, said arrhythmia detection control parameter changes in a third predetermined direction and magnitude within a predetermined number of cardiac cycles, and said short-term uniformity measurement changes in a fourth predetermined direction and magnitude within a predetermined number of cardiac cycles.

27. A method of detecting and reverting cardiac arrhythmias in accordance with claim 26, wherein said arrhythmia detection control parameter is a paced depolarization integral and said fibrillation is characterized in general by a decreasing paced depolarization integral occurring simultaneously with a decreasing short-term uniformity of paced depolarization time samples.

28. A method of detecting and reverting cardiac arrhythmias in accordance with claim 26, further comprising the steps of:

generating defibrillation shocks; and

controlling said defibrillation generating step to generate shocks in response to classification of a cardiac rhythm as fibrillation in said classifying step.

29. An arrhythmia detection and antiarrhythmia pacing device adapted to be implanted in a patient for the reversion of tachycardias, comprising:

means for generating heart stimulation pulses,

means for measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

means based upon the sensing of an evoked potential for periodically ascertaining the value of a measured arrhythmia detection control parameter,

means for detecting changes over time in said measured arrhythmia detection control parameter,

means for sensing heartbeats,

means responsive to said heartbeat sensing means for determining a heart rate, and

means responsive to said detecting means and said heart rate determining means for classifying a cardiac rhythm as asystole when said heart rate is slower than a predetermined bradycardia rate and said arrhythmia detection control parameter remains essentially unchanged within a predetermined number of cardiac cycles, and for classifying a cardiac rhythm as fibrillation when said heart rate is slower than a predetermined bradycardia rate and said arrhythmia detection control parameter changes in a predetermined direction and magnitude within a predetermined number of cardiac cycles.

30. An arrhythmia detection and antiarrhythmia pacing device in accordance with claim 29, wherein said arrhythmia control parameter is a paced depolarization integral and said asystole is characterized in general by an essentially unchanging paced depolarization integral and said fibrillation is characterized in general by a reduced paced depolarization integral.

31. A method of detecting and reverting cardiac arrhythmias of a patient'"'"'s heart using an antiarrhythmia pacing device, comprising the steps of:

generating heart stimulation pulses,

measuring an evoked potential of the patient'"'"'s heart that is responsive to said stimulation pulses,

periodically ascertaining the value of a measured arrhythmia detection control parameter which is based upon the sensing of an evoked potential,

detecting changes over time in said measured arrhythmia detection control parameter,

sensing heartbeats,

timing the interval between sensed heartbeats to determine a heart rate, and

classifying a cardiac rhythm as asystole when said heart rate is slower than a predetermined bradycardia rate and said arrhythmia detection control parameter remains essentially unchanged within a predetermined number of cardiac cycles, and classifying a cardiac rhythm as fibrillation when said heart rate is slower than a predetermined bradycardia rate and said arrhythmia detection control parameter changes in a predetermined direction and magnitude within a predetermined number of cardiac cycles.