Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye

• US 5,185,152 A
• Filed: 08/13/1991
• Issued: 02/09/1993
• Est. Priority Date: 01/10/1990
• Status: Expired due to Fees

• Current Assignee: Gholam A. Peyman
• Original Assignee: Gholam A. Peyman
• Inventors: Peyman, Gholam A.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): BENSTON JR, WILLIAM E
• Application Number:
  US07/747,432
• Time in Patent Office: 546 Days
• Field of Search: 424/427, 424/428, 424/450, 424/429, 424/469, 264/1.1, 264/2.6
• US Class Current: 424/427
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

A method and device for delivering a drug to the cornea and anterior chamber of an eye are disclosed. A drug is entrapped in microspheres of poly(lactic acid), poly(glycolic acid), a copolymer of lactic acid and glycolic acid, poly(ethylene-vinyl acetate), or a mixture of poly(lactic acid) and poly(glycolic acid). The microspheres are combined with a hydrophilic polymer and placed in contact with the eye.

Claims

1. A method for delivering a drug directly to a cornea and anterior chamber of an eye comprising the steps of:

entrapping a drug in microspheres made of a bioerodible polymer selected from the group consisting of poly(lactic acid), poly(glycolic acid), a copolymer of lactic acid an glycolic acid, and poly)ethylene-vinyl acetate), or a mixture of poly(lactic acid) and poly(glycolic acid),

thereafter combining the microspheres with a hydrophilic polymer and forming a corneal shield for placement directly over the cornea, and

thereafter placing the hydrophilic polymer corneal shield in contact with a cornea of an eye, whereby, as the microspheres dissolve, the drug is delivered directly to the cornea and anterior chamber of the eye.

2. The method of claim 1 wherein the hydrophilic polymer is collagen.

3. The method of claim 1 wherein the step of molding the hydrophilic polymer to a corneal shield occurs before the step of combining the microspheres with the hydrophilic polymer.

4. The method of claim 3 wherein the step of combining the microspheres with the hydrophilic polymer includes soaking the corneal shield in a solution containing the microspheres.

5. The method of claim 1 wherein the step of molding the hydrophilic polymer occurs after the step of combining the microspheres with the hydrophilic polymer.

6. The method of claim 1 wherein said hydrophilic polymer is transparent.

7. The method of claim 1 wherein said hydrophilic polymer is semi-transparent.

10. The method of claim 1 wherein the hydrophilic polymer is selected from the group consisting of collagen, polysaccharides, mucopolysaccharides, glycoproteins, hydrogel, and silicone, or a combination of these materials.

8. A device for delivering a drug directly to a cornea and anterior chamber of an eye, the combination comprising:

a corneal shield made of a hydrophilic polymer to be placed in contact with a cornea of an eye,

microspheres dispersed in said hydrophilic polymer, said microspheres being made of a bioerodible polymer selected from the group consisting of poly(lactic acid), poly(glycolic acid), a copolymer of lactic acid and glycolic acid, and poly)ethylene-vinyl acetate), or a mixture of poly(lactic acid) and poly(glycolic acid), and

a drug entrapped by said microspheres.

9. The method of claim 8 wherein said hydrophilic polymer is collagen.

11. The method of claim 8 wherein the hydrophilic polymer is selected from the group consisting of collagen, polysaccharides, mucopolysaccharides, glycoproteins, hydrogel, and silicone, or a combination of these materials.

12. A method for delivering a drug directly to a cornea and anterior chamber of an eye comprising the steps of

forming a solution of microspheres entrapping at least one drug, said microspheres being made of a polymer selected from the group consisting of polylactic acid, polyglycolic acid, copolymers of lactic acid and glycolic acid, polyethylene-vinyl acetate and mixtures of polylactic acid and polyglycolic acid,

forming a corneal shield from a hydrophilic polymer for placement directly over the cornea,

immersing the corneal shied in the solution of microspheres for sufficient time to absorb the microspheres, and

placing the hydrophilic polymer corneal shield in contact with the cornea of an eye to dissolve the microspheres and release the drug directly to the cornea and anterior chamber of the eye.

13. The method according to claim 12, wherein the second forming step comprises forming the corneal shield in a dehydrated condition.

14. The method according to claim 12, wherein the second forming step comprises forming the corneal shield from collagen.

15. The method according to claim 12 and further comprising the steps of

removing the corneal shield from the eye and immersing the corneal shield in a second solution of the microspheres for sufficient time for the corneal shield to absorb the microspheres;

and

placing the corneal shield in contact with the cornea to dissolve the microspheres and relates the drug directly to the cornea.