NMR measurements using recursive RF excitation

• US 5,185,574 A
• Filed: 08/09/1991
• Issued: 02/09/1993
• Est. Priority Date: 08/09/1991
• Status: Expired due to Term

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Greenleaf, James F., Ehman, Richard L.
• Primary Examiner(s): Tokar, Michael J.
• Application Number:
  US03/342,980
• Time in Patent Office: 550 Days
• Field of Search: 324/300, 324/303, 324/306, 324/307, 324/309, 324/310, 324/311, 324/312, 324/313, 324/314, 324/318, 324/322, 128/653.2, 128/653.5, 128/653.3
• US Class Current: 324/309
• CPC Class Codes: G01R 33/446 Multifrequency selective RF pulses, e.g. multinuclear acquisition mode spatially selective RF pulses G01R33/4833
• CPC Class Codes: G01R 33/56 Image enhancement or correction, e.g. subtraction or averaging techniques , e.g. improvement of signal-to-noise ratio and resolution

Abstract

An NMR echo signal is produced in a recursive process in which one or more pulse sequences are executed and the NMR echo signal produced by each pulse sequence is employed to shape the RF excitation pulse employed in the subsequent pulse sequence. The series of NMR echo signals produced by this recursive process are progressively modified to enhance the signals produced by prominent features in the subject.

Claims

1. In an NMR system for acquiring an NMR echo signal by executing a pulse sequence in which a first RF excitation pulse produces transverse magnetization in spins subject to a polarizing magnetic field and an NMR echo signal is subsequently produced and acquired by a receiver, the improvement comprising:

means for storing the acquired NMR echo signal;

means coupled to the storing means for producing an RF excitation waveform that has a shape which is determined by the acquired NMR echo signal; and

means coupled to the last named means for executing a pulse sequence in which an RF excitation pulse has a waveform determined by the acquired NMR echo signal from a previous pulse sequence.

2. A method for producing an NMR echo signal in an NMR system, which includes:

producing transverse magnetization in spins subjected to a polarizing magnetic field by generating an RF excitation pulse;

acquiring an NMR echo signal which is produced as a result of the transverse magnetization;

employing the acquired NMR echo signal to determine the shape of a subsequent RF excitation pulse;

producing further transverse magnetization in spins subjected to the polarizing magnetic field by generating said subsequent RF excitation pulse and

acquiring a further NMR echo signal produced as a result of the further transverse magnetization.

3. The method as recited in claim 2 in which a readout magnetic field gradient is applied to the spins while the RF excitation pulses are produced and while the NMR echo signals are acquired.

4. The method as recited in claim 2 in which an RF echo pulse is produced after each of the RF excitation pulses and before the acquisition of each of the NMR echo signals.

5. The method as recited in claim 2 in which the shape of the subsequent RF excitation pulse is substantially the same as the shape of the acquired NMR echo signal.

6. The method as recited in claim 5 in which the shape of the subsequent RF excitation pulse is determined by modulating the amplitude of an RF carrier signal.

7. The method as recited in claim 2 in which the acquired NMR echo signal is employed to determine the shape of a subsequent RF excitation pulse by:

a) Fourier transforming the acquired NMR echo signal;

b) altering the shape of the transformed NMR echo signal to produce filtered projection data; and

c) inverse Fourier transforming the filtered projection data.

8. The method as recited in claim 7 in which step b) is performed by locating a prominent peak in the transformed NMR echo signal and reducing the value of the transformed NMR echo signal at the located prominent peak.

9. The method as recited in claim 3 in which the readout magnetic field gradient has components directed along two axes.

10. In an NMR system a method for acquiring NMR data for producing an image, the steps comprising:

a) producing a selective presaturation RF pulse by;

i) producing transverse magnetization in spins subjected to a polarizing magnetic field by generating an RF excitation pulse;

ii) acquiring an NMR signal which is produced as a result of the transverse magnetization; and

iii) employing the acquired NMR signal to determine the shape of the selective presaturation RF pulse;

b) applying the selective presaturation RF pulse to the spins subjected to the polarizing magnetic field; and

c) performing a pulse sequence to acquire an NMR signal from the spins subjected to the polarizing magnetic field, the NMR signal being used to produce an image.

11. The method as recited in claim 10 in which a readout gradient field is applied to the spins when the RF excitation pulse is generated and the NMR signal is acquired in step a).

12. The method as recited in claim 11 in which the readout gradient has components directed along two axes.

13. The method as recited in claim 12 in which the components of the readout gradient are time varying.