Dispersion to limit penetration of aqueous solutions into a membrane

• US 5,187,100 A
• Filed: 11/19/1991
• Issued: 02/16/1993
• Est. Priority Date: 05/29/1990
• Status: Expired due to Term

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Poulos, Darwin R., Teodorczyk, Maria, Matzinger, David P.
• Primary Examiner(s): Johnston, Jill A.
• Assistant Examiner(s): BHAT, NINA NMN
• Application Number:
  US07/795,285
• Time in Patent Office: 455 Days
• Field of Search: 436/8-18, 436/528, 436/533, 436/534, 422/56, 422/61, 435/14, 252/408.1, 252/352, 524/563
• US Class Current: 436/16
• CPC Class Codes: G01N 2496/25 containing added polymers to stabilise biological material against degradation or mantain viscosity or density, e.g. gelatin, polyacrylamides, polyvinyl alcohol casein G01N2333/4731, albumins G01N2333/76, polysaccharides G01N2400/10
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/96 involving blood or serum control standard
• CPC Class Codes: Y10S 516/02 Organic and inorganic agents containing, except water
• CPC Class Codes: Y10T 436/104998 Glucose, ketone, nitrate standard or control
• CPC Class Codes: Y10T 436/106664 Blood serum or blood plasma standard or control

Abstract

A control solution for use with a porous reagent strip comprises a flexible semisolid polymer dispersed in water, such as polyvinyl acetate in distilled water, with appropriate control glucose concentration levels. This solution is useful in mimicking whole blood in conjunction with porous reagent strips to determine compliance of the strips and meters to established measurement and performance criteria.

Claims

1. A control solution which mimics whole blood, for use with a porous reagent strip comprising:

a suspension of about 40% to about 55% solid polyvinyl acetate particles dispersed in water, and a dispersant to maintain said particles in suspension and glucose.

2. The solution of claim 1 wherein the dispersant is silicon dioxide.

3. The solution of claim 1 wherein the ratio of polyvinyl acetate suspension to water by weight is between 1:

5 and 1;

8.

4. The solution of claim 3 further comprising an offset adjusting dye for use with a reflectance measurement system.

5. The solution of claim 4 further comprising 0.0075% copper phthalocyanine tetrasulfonic acid tetrasodium salt.

6. The solution of claim 3 further comprising polyvinyl acetate having a particle size between 0.5 and 10 microns.

7. A control solution for use with a porous reagent strip having about 0.8 micron diameter pore size, said solution mimicking whole blood on said strip, comprising:

a 40%-55% polyvinyl acetate suspension and water in a ratio of between 1;

5 and 1;

8 by weight, a dispersant to maintain said polyvinyl acetate in suspension and glucose.

8. The solution of claim 7 wherein the ratio of polyvinyl acetate suspension to water is about 1:

6.

9. The solution of claim 8 further comprising 0.0075% copper phthalocyanine tetrasulfonic acid tetrasodium salt.

10. The solution of claim 8 wherein the dispersant is silicon dioxide.

11. The solution of claim 8 wherein the amount of solid polyvinyl acetate in the polymer suspension is between about 40% to about 55%.