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Use of a Glycine B partial agonist as an antipsychotic

  • US 5,187,171 A
  • Filed: 01/09/1989
  • Issued: 02/16/1993
  • Est. Priority Date: 01/09/1989
  • Status: Expired due to Term
First Claim
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1. A method to treat a psychotic disorder by administering to a subject susceptible to or suffering from a psychotic disorder a therapeutically-effective amount of a Glycine B partial agonist or a prodrug thereof selected from the family of compounds of the formula ##STR9## wherein R1 is selected from hydrido, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl and aryl;

  • wherein R2 is selected from hydrido, alkyl, aralkyl, aryl, ##STR10## wherein R1 and R2 which are attached to the same nitrogen atom may be taken together to form a Schiff-base derived group selected from derivatives of aldehydes and ketones;

    wherein R3 is selected from hydrido, alkyl, haloalkyl, alkoxy, alkoxyalkyl, cycloalkyl, aralkyl and aryl;

    or a pharmaceutically-acceptable salt thereof.

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