Use of a Glycine B partial agonist as an antipsychotic
First Claim
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1. A method to treat a psychotic disorder by administering to a subject susceptible to or suffering from a psychotic disorder a therapeutically-effective amount of a Glycine B partial agonist or a prodrug thereof selected from the family of compounds of the formula ##STR9## wherein R1 is selected from hydrido, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl and aryl;
- wherein R2 is selected from hydrido, alkyl, aralkyl, aryl, ##STR10## wherein R1 and R2 which are attached to the same nitrogen atom may be taken together to form a Schiff-base derived group selected from derivatives of aldehydes and ketones;
wherein R3 is selected from hydrido, alkyl, haloalkyl, alkoxy, alkoxyalkyl, cycloalkyl, aralkyl and aryl;
or a pharmaceutically-acceptable salt thereof.
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Abstract
A class of Glycine B partial agonists is described for use for treatment of psychosis. Preferred Glycine B partial agonists include amino-isoxazolidone compounds such as D-cycloserine and its prodrugs.
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8 Claims
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1. A method to treat a psychotic disorder by administering to a subject susceptible to or suffering from a psychotic disorder a therapeutically-effective amount of a Glycine B partial agonist or a prodrug thereof selected from the family of compounds of the formula ##STR9## wherein R1 is selected from hydrido, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl and aryl;
- wherein R2 is selected from hydrido, alkyl, aralkyl, aryl, ##STR10## wherein R1 and R2 which are attached to the same nitrogen atom may be taken together to form a Schiff-base derived group selected from derivatives of aldehydes and ketones;
wherein R3 is selected from hydrido, alkyl, haloalkyl, alkoxy, alkoxyalkyl, cycloalkyl, aralkyl and aryl;
or a pharmaceutically-acceptable salt thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- wherein R2 is selected from hydrido, alkyl, aralkyl, aryl, ##STR10## wherein R1 and R2 which are attached to the same nitrogen atom may be taken together to form a Schiff-base derived group selected from derivatives of aldehydes and ketones;
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