Treatment of eating disorders by nerve stimulation
First Claim
1. A method of treating patients with eating disorders by use of a therapy which alleviates a symptom of the disorder, which comprises the steps of:
- detecting a preselected event indicative of an imminent need for treatment of the specific eating disorder of interest, andresponding to the detected occurrence of the preselected event by applying a predetermined stimulating signal to the patient'"'"'s vagus nerve appropriate to alleviate said symptom of the eating disorder of interest.
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Abstract
A method of treating patients with compulsive eating disorders includes the steps of detecting a preselected event indicative of an imminent need for treatment of the specific eating disorder of interest, and responding to the detected occurrence of the preselected event by applying a predetermined stimulating signal to the patient'"'"'s vagus nerve appropriate to alleviate the effect of the eating disorder of interest. For example, the preselected event may be a specified level of food consumption by the patient within a set interval of time, or the commencement of a customary mealtime according to the patient'"'"'s circadian cycle, or the passage of each of a sequence of preset intervals of time, or the patient'"'"'s own recognition of the need for treatment by voluntarily initiating the application of the stimulating signal to the vagus nerve. In cases in which the disorder is compulsive eating to excess, the stimulating signal is predetermined to produce a sensation of satiety in the patient. The occurrence of the preselected event is detected by summing the number of swallows of food by the patient within the set interval of time. In cases where the disorder is compulsive refusal to eat (anorexia nervosa), the stimulating signal is predetermined to produce a sensation of hunger or to suppress satiety in the patient.
1114 Citations
19 Claims
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1. A method of treating patients with eating disorders by use of a therapy which alleviates a symptom of the disorder, which comprises the steps of:
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detecting a preselected event indicative of an imminent need for treatment of the specific eating disorder of interest, and responding to the detected occurrence of the preselected event by applying a predetermined stimulating signal to the patient'"'"'s vagus nerve appropriate to alleviate said symptom of the eating disorder of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. Apparatus for treating patients with eating disorders by application of a modulating signal to the patient'"'"'s vagus nerve to stimulate or inhibit neural impulses and produce excitatory or inhibitory neurotransmitter release by the nerve according to the specific nature of the eating disorder, comprising:
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neurostimulator means for generating an electrical output signal in response to activation thereof, said neurostimulator means including sensing means for detecting the occurrence of a selected event indicative of the need for imminent treatment of the eating disorder, and including activating means responsive to the detection for activating said neurostimulator means, and lead/electrode means responsive to generation of the electrical output signal by said neurostimulator means for application thereof as said modulating signal to the patient'"'"'s vagus nerve. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A neurostimulator for treatment of eating disorders in human patients, comprising
an implantable electrical signal generator, programming means for selectively programming the parameters of the electrical signal generated by the generator to modulate electrical activity of the patient'"'"'s vagus nerve to evoke different sensations by the patient according to the nature of the eating disorder being treated, means for applying the generated signal to the patient'"'"'s vagus nerve, and means for detecting a symptom of the eating disorder being treated to activate the generation of the programmed electrical signal by the generator.
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19. A method for treating and controlling compulsive eating disorders characterized by compulsive action exhibited by the individual suffering from the disorder, which comprises the steps of:
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detecting a known symptom of the eating disorder of interest indicative of imminent need for intervention to control the disorder, and responding to the detected occurrence of said symptom by modulating the vagal activity of the individual suffering the eating disorder to treat the symptom and deter the compulsive action associated with the disorder.
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Specification