Method of controlling drug release by resonant sound wave

• US 5,190,766 A
• Filed: 04/12/1991
• Issued: 03/02/1993
• Est. Priority Date: 04/16/1990
• Status: Expired due to Term

• Current Assignee: Ken Ishihara
• Original Assignee: Ken Ishihara
• Inventors: Ishihara, Ken
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Hulina, Amy
• Application Number:
  US07/684,386
• Time in Patent Office: 690 Days
• Field of Search: 424/489, 424/491, 424/493, 424/499, 604/22
• US Class Current: 424/489
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 49/223 Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
• CPC Class Codes: A61K 9/5052 Proteins, e.g. albumin
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

A drug carrier carrying a drug is introduced to a diseased region of the living body while it is observed in the B mode echograms. The drug carrier is irradiated with an ultrasonic wave for strongly vibrating the drug carrier, thereby releasing the drug from the drug carrier for curing the diseased portion.

Claims

1. A method of controlling a release of a drug from a drug carrier or drug holding structure comprising the steps of:

measuring the acoustic characteristics of a drug carrier or drug holding structure in the region in which a drug is to be released in order to calculate the resonance frequency of said drug carrier or drug holding structure and irradiating said drug carrier or drug holding structure having a sharp acoustic resonance with a sound wave having a frequency including the resonance frequency of said drug carrier or drug holding structure in said region thereby controlling the release of said drug from said drug carrier or drug holding structure.

2. The method of controlling the release of a drug according to claim 1, which further comprises administering said drug carrier or drug holding structure into a living body prior to irradiating it with a sound wave.

3. The method of controlling the release of a drug according to claim 2, further comprising the step of observing the distribution of said drug carriers in the living body by ultrasonic tomography.

4. The method of controlling the release of a drug according to claim 2, further comprising the steps of situating said drug carrier or drug holding structure in the region of the living body in which said drug is to be released in order to calculate the resonance frequency prior to generating a sound wave having a frequency which includes the resonance frequency of said drug carrier or drug holding structure.

5. The method of controlling the release of a drug according to claim 1, wherein said drug carrier is a microcapsule made of albumin, and said drug is released from said drug carrier by irradiating said microcapsule with a resonant ultrasonic wave of 1.5 to 2.0 MHz.

6. The method of controlling the release of a drug according to claim 1, wherein said drug carrier is a hollow microcapsule which contains a gas therein and said hollow microcapsule is used in a liquid, in a sol or in a living body.