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Synthesis of protease inhibitor

  • US 5,192,668 A
  • Filed: 02/27/1992
  • Issued: 03/09/1993
  • Est. Priority Date: 10/11/1990
  • Status: Expired due to Fees
First Claim
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1. A method of preparing a compound of the formula:

  • ##STR4## comprising the steps of (1) providing a quantity of N-(Cis-2(R)-hydroxy-1(S)-indanyl)-5(S)-(1,1-dimethylethoxycarbonylamino)-4(S)-hydroxy-6-phenyl-2(R)-((4-(2-(4-morpholinyl)ethoxy)phenyl)methyl)-hexanamide of the formula;

    ##STR5## (2) incubating the compound of step (1) with Streptomyces culture #S-26-487 at temperatures ranging from about 20°

    C. to about 42°

    C. and at a pH in the range of from about 5.5 to 8.0 under aerobic conditions to prepare compound 1; and

    (3) isolating the compound produced by step (2).

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