Anti-rheumatoid arthritic drugs in the treatment of dementia

• US 5,192,753 A
• Filed: 04/23/1991
• Issued: 03/09/1993
• Est. Priority Date: 04/23/1991
• Status: Expired due to Term

• Current Assignee: Sun Health Corporation (Riverside Partners LLC), University of British Columbia
• Original Assignee: Sun Health Corporation (Riverside Partners LLC)
• Inventors: Sibley, John, Rogers, Joseph, McGeer, Patrick L., McGeer, Edith
• Primary Examiner(s): Waddell, Frederick E.
• Assistant Examiner(s): Henley, III, Raymond J.
• Application Number:
  US07/689,499
• Time in Patent Office: 686 Days
• Field of Search: 514/165, 514/570, 514/549, 514/552, 514/560, 514/878, 514/879, 514/159, 514/162, 514/226.5, 514/356, 514/375, 514/404, 514/419, 514/420, 514/423, 514/428, 514/429 , 514/448, 514/567, 514/569
• US Class Current: 514/159
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/235 having an aromatic ring attached to a carboxyl group
• CPC Class Codes: A61K 31/38 having sulfur as a ring hetero atom
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/405 Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/42 Oxazoles
• CPC Class Codes: A61K 31/425 Thiazoles
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/54 having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/621 having the hydroxy group in position 2 esterified, e.g. benorylate
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

This invention pertains to the novel use of anti-rheumatoid arthritic drugs in the treatment of dementia. A method of treating dementia in human beings which comprises administering to the human being a therapeutic amount of a non-steroidal anti-inflammatory drug (NSAID) which has the ability to inhibit prostaglandin synthesis in the human being.

Claims

1. A method of treating dementia in a human being in need thereof which comprises administering to said human being on a daily basis a sufficient amount of a non-steroidal anti-inflammatory drug to inhibit prostoglandin synthesis in vivo but insufficient to induce unwanted side effects in said human.

2. A method as claimed in claim 1 wherein the drug is selected from the group consisting of derivatives of arylcarboxylic acids, arylalkanoic acids and enolic acids, and therapeutically acceptable salts thereof.

3. A method as claimed in claim 2 wherein the arylcarboxylic acid is a salicylic acid or an anthranilic acid derivative;

the arylalkanoic acid is arylacetic, arylpropionic, heteroarylacetic, indoleacetic or indeneacetic acid; and

the enolic acid is pyrazolidinedione or oxicam, and therapeutically acceptable salts thereof.

4. A method of treating dementia in a human being in need thereof which comprises administering to said human being a therapeutic amount of a non-steroidal anti-inflammatory substance selected from the group consisting of salicylic acid, acetylsalicylic acid, diflunisal, choline magnesium trisalicylate, salicylate, benorylate, flufenamic acid, mefenamic acid, meclofenamic acid, niflumic acid, diclofenac, fenclofenac, alclofenac, fentiazac, ibuprofen, flurbiprofen, ketoprofen, naproxen, fenoprofen, fenbufen, suprofen, indoprofen, tiaprofenic acid, benoxaprofen, pirprofen, tolmetin, zomepirac, clopinac, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, azapropazone, feprazone, piroxicam, isoxicam and sudoxicam.

5. A method as claimed in claim 4 wherein the daily dosage is from 10 mg to 3 g of substance per 100 kg of body weight of the human being.

6. A method of treating dementia in a human being in need thereof which comprises administering to said human being a daily dosage of from about 50 mg to about 300 mg of indomethacin per 100 kg of body weight of said human being.