Removable device for delivering beneficial agents orally

• US 5,194,003 A
• Filed: 01/03/1992
• Issued: 03/16/1993
• Est. Priority Date: 06/13/1988
• Status: Expired due to Term

• Current Assignee: Transpharm Group Incorporated
• Original Assignee: Transpharm Group Incorporated
• Inventors: Garay, Anne-Ly, Garay, Gabriel L., Tacy, Robert
• Primary Examiner(s): Mancene, Gene
• Assistant Examiner(s): Lucchesi, Nicholas D.
• Application Number:
  US07/816,796
• Time in Patent Office: 438 Days
• Field of Search: 433/80, 433/215, 433/229, 433/6
• US Class Current: 433/215
• CPC Class Codes: A61C 19/063 Medicament applicators for teeth or gums, e.g. treatment with fluorides
• CPC Class Codes: A61J 7/0092 for holding medicines in, or fixing medicines on, a tooth, e.g. holder containing medicines fixed on a tooth medicament applicators for teeth or gums A61C19/063
• CPC Class Codes: A61K 9/0063 Periodont
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A device for delivering beneficial agents such as drugs orally for sustained time periods comprising a support member that is formfit or clasped over or around the teeth and one or more reservoir members that is/are carried on an exterior surface of the support along the labial, buccal or lingual surfaces of the teeth and is adapted to hold the agent and release it to the oral cavity for achieving a local effect within the mouth, an effect elsewhere in the gastrointestinal tract or systemically.

Claims

1. A device that is adapted to be suspended and held in place with an oral cavity including an upper jaw and were jaw by a plurality of teeth of one of said jaws and/or tissues adjoining the teeth and from which a beneficial agent is released into the oral cavity in a sustained manner comprising:

(a) a partial overlay comprising a first section that is form fitting to a first segment of teeth on one of said jaws, a second section that is form fitting to a second segment of teeth on said one of said jaws, said first segment being spaced from said second segment and an interconnecting middle section; and

(b) at least one beneficial agent reservoir that is carried on an exterior surface of the partial overlay, extends laterally of the labial, buccal or lingual surface of the teeth, is adapted to hold the beneficial agent and has a multiplicity of open-agent-release orifices that permit increase of saliva into the reservoir to dissolve the agent from the reservoir.

2. The device of claim 1 wherein said first section caries a beneficial agent reservoir and said second section carries a beneficial agent reservoir.