Packing material for reversed phase chromatography and process for its preparation

• US 5,194,333 A
• Filed: 12/18/1990
• Issued: 03/16/1993
• Est. Priority Date: 12/18/1989
• Status: Expired due to Term

• Current Assignee: Tosoh Corporation
• Original Assignee: Tosoh Corporation
• Inventors: Komiya, Katsuo, Moriyama, Hiroyuki, Ohnaka, Tadao
• Primary Examiner(s): Thibodeau, Paul J.
• Assistant Examiner(s): Le, Hoa T.
• Application Number:
  US07/629,625
• Time in Patent Office: 819 Days
• Field of Search: 428/402, 428/405, 428/447, 428/429, 521/91, 436/527, 528/10, 210/656, 210/660
• US Class Current: 428/405
• CPC Class Codes: B01D 15/325 Reversed phase
• CPC Class Codes: B01J 20/286 Phases chemically bonded to a substrate, e.g. to silica or to polymers
• CPC Class Codes: B01J 20/287 Non-polar phases; Reversed phases
• CPC Class Codes: B01J 20/3204 Inorganic carriers, supports or substrates
• CPC Class Codes: B01J 20/3272 Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 2220/54 Sorbents specially adapted for analytical or investigative chromatography
• CPC Class Codes: Y10T 428/2995 Silane, siloxane or silicone coating
• CPC Class Codes: Y10T 428/31612 As silicone, silane or siloxane
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane

Abstract

A packing material for reversed phase chromatography, which comprises silica gel with its entire surface substantially coated with repeating units of a polycarbosilane of the formula (I): ##STR1## wherein R₁ is an octyl group, an octadecyl group or a phenyl group, R₂ is a methyl group or a methylene group, and n is a positive integer.

Claims

1. A packing material for reversed phase chromatography, which comprises silica gel with its surface coated with repeating units of a polycarbosilane of the formula (I):

##STR8## wherein R₁ is an octyl group, an octadecyl group or a phenyl group, R₂ is a methyl group or a methylene group, and n is a positive integer, wherein the silica gel has pores having a pore size of from 20 to 10,000 Å

.

2. The packing material for reversed phase chromatography according to claim 1, wherein R₂ of the polycarbosilane of the formula (I) is a methyl group.

3. A process for preparing a packing material for reversed phase chromatography as defined in claim 1, which comprises treating a polysilane coated on silica atmosphere, so as to convert the polysilane to polycarbosilane, wherein he silica gel has pores having a pore size of from 20 to 10,000 Å

.

4. The process according to claim 3, wherein the polysilane is a linear polysilane of the formula (II):

##STR9## wherein R₃ is an octyl group, an octadecyl group or a phenyl group, and m is a positive integer.

5. The process according to claim 3, wherein the polysilane is a cyclic polysilane of the formula (III):

##STR10## wherein R₃ is an octyl group, an octadecyl group or a phenyl group, and 1 is a positive integer.

6. The process according to claim 3, wherein the inert atmosphere is nitrogen, helium or argon.