System and method for enhancing collateral cardiac blood flow

• US 5,195,518 A
• Filed: 09/06/1991
• Issued: 03/23/1993
• Est. Priority Date: 09/06/1991
• Status: Expired due to Fees

• Current Assignee: Thomas Jefferson University (Main Line Health System)
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Mannion, John D., Magno, Michael G.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/756,157
• Time in Patent Office: 564 Days
• Field of Search: 600/16, 600/17, 623/3, 128/419 PG, 128/419 P, 128/421
• US Class Current: 607/9
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 60/191 mechanically acting upon the outside of the patient's native heart, e.g. compressive structures placed around the heart
• CPC Class Codes: A61M 60/289 Devices for mechanical circulatory actuation assisting the residual heart function by means mechanically acting upon the patient's native heart or blood vessel structure, e.g. direct cardiac compression [DCC] devices
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/546 of blood flow, e.g. by adapting rotor speed
• CPC Class Codes: A61M 60/562 for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
• CPC Class Codes: A61M 60/878 Electrical connections within the patient's body
• CPC Class Codes: A61M 60/882 Devices powered by the patient, e.g. skeletal muscle powered devices
• CPC Class Codes: A61N 1/36042 of grafted tissue, e.g. skeletal muscle

Abstract

There is provided a system and method for enhancing collateral blood flow to the heart of a patient having angina with otherwise normal cardiac function. Skeletal muscle from the patient is attachd to the left ventricle, and stimulated with both chronic and acute stimulation to provide chronic long-term collateral blood flow and increased acute collateral blood flow during periods of exercise or times when angina is at greater risk. The stimulation system includes a sensor for determining cardiac demand and/or for sensing natural heartbeats, and processing circuitry for acutely increasing stimulation of the skeletal muscle in response to the sensor or natural rate. The system is further provided with internal clock means for causing cessation of delivery of stimulus pulses during periods of low activity, and external programming means for programming changes in either chronic or acute stimulation.

Claims

1. A method of providing collateral blood flow through a patient'"'"'s skeletal muscle to a patient'"'"'s myocardial tissue, comprising:

a) operatively connecting a skeletal muscle pedicle of the patient to said myocardial tissue, the muscle pedicle retaining its source of blood flow;

b) attaching a stimulator to said skeletal muscle and delivering stimulus pulses from said stimulator to said skeletal muscle; and

c) controlling said stimulator to deliver chronic stimulus pulses to said muscle in accordance with a chronic pattern so as to provide chronic collateral blood flow from said muscle to said myocardium, and changing the pattern of delivering stimulus pulses for acute periods during increased levels of patient cardiac demand, said controlling providing for increased collateral flow from said skeletal muscle to said myocardial tissue.

2. The method as described in claim 1, comprising sensing a body parameter reflective of cardiac demand, and controlling said acute stimulation in response to said sensed parameter.

3. The method as described in claim 1, wherein said attaching step is performed by suturing said pedicle to the patient'"'"'s pericardium.

4. The method as described in claim 1, wherein the step of chronically stimulating comprises delivering stimulus pulses to said skeletal muscle at a rate less than the patient'"'"'s heart rate.

5. The method as described in claim 4, wherein said chronic stimulation pulses are delivered substantially synchronously with patient heartbeats.

6. The method as described in claim 5, wherein said changing comprises delivering stimulus pulses which are at a multiple of said chronic rate.

7. The method as described in claim 1, wherein said changed pattern for acute periods comprises increasing the energy delivered to the skeletal muscle with each stimulus pulse.

8. The method as described in claim 1, further comprising the step of periodically automatically determining a rest period, and inhibiting delivery of chronic stimulation pulses during said rest period.

9. The method as described in claim 1, comprising delivering a control signal from external to said patient to enable an acute increase in stimulation of said skeletal muscle.

10. The method as described in claim 1, further comprising the introduction of growth factors following the attaching of said skeletal muscles to said heart.

11. The method as described in claim 1, wherein said chronic pattern comprises delivering stimulus pulses synchronized to a first predetermined fraction of the patient'"'"'s natural heartbeats, and said changed pattern comprises delivering stimulus pulses synchronized to a second predetermined fraction of the patient'"'"'s natural heartbeats, where said second fraction is greater than said first fraction.

12. A method of treating a patient having angina by electrically stimulating collateral blood flow from a first portion of the patient'"'"'s heart to a normally functioning portion of said patient'"'"'s myocardium, comprising operatively connecting a portion of said patient'"'"'s skeletal muscle to said first portion and to said normally functioning myocardial portion, and stimulating said skeletal muscle with a pattern of stimulus pulses so as to electrically induce said collateral blood flow from said first portion through said skeletal muscle to said normally functioning portion without substantial mechanical activation of the patient'"'"'s heart.