Method and system for monitoring of blood constituents in vivo
First Claim
1. In a method for determining the concentration of a constituent of blood of a patient employing a sensor located in a blood vessel for producing a signal related to the concentration of said constituent of blood, the improvement which comprises obtaining said signal while at least one of the following is introduced into said blood vessel:
- (1) at least one of an added vasodilator component and an added vasodilation promoter in an amount effective to reduce the vasoconstriction caused by the presence of said sensor in said blood vessel and (2) at least one of an added platelet/white cell inhibitor component and an added platelet/white cell deactivation promoter in an amount effective to reduce at least one of;
(A) the platelet activation caused by the presence of said sensor in said blood vessel; and
(B) the white cell activation caused by the presence of said sensor in said blood vessel;
thereby providing a more accurate determination of the concentration of the blood constituent.
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Accused Products
Abstract
A method for determining the concentration of a constituent of blood employing a sensor in or near a catheter in a blood vessel for producing a signal related to the concentration of the constituent of blood is disclosed. The improvement comprises obtaining the signal while at least one of the following is present in the blood vessel: (1) an added vasodilator component and/or vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of the catheter in the blood vessel and (2) an added platelet/white cell inhibitor component and/or a platelet/white cell deactivation promotor in an amount effective to reduce the platelet and/or white cell activation caused by the presence of the catheter in the blood vessel.
155 Citations
39 Claims
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1. In a method for determining the concentration of a constituent of blood of a patient employing a sensor located in a blood vessel for producing a signal related to the concentration of said constituent of blood, the improvement which comprises obtaining said signal while at least one of the following is introduced into said blood vessel:
- (1) at least one of an added vasodilator component and an added vasodilation promoter in an amount effective to reduce the vasoconstriction caused by the presence of said sensor in said blood vessel and (2) at least one of an added platelet/white cell inhibitor component and an added platelet/white cell deactivation promoter in an amount effective to reduce at least one of;
(A) the platelet activation caused by the presence of said sensor in said blood vessel; and
(B) the white cell activation caused by the presence of said sensor in said blood vessel;
thereby providing a more accurate determination of the concentration of the blood constituent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- (1) at least one of an added vasodilator component and an added vasodilation promoter in an amount effective to reduce the vasoconstriction caused by the presence of said sensor in said blood vessel and (2) at least one of an added platelet/white cell inhibitor component and an added platelet/white cell deactivation promoter in an amount effective to reduce at least one of;
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19. A method for determining the concentration of a constituent of a patient'"'"'s blood comprising:
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introducing the distal end portion of a catheter into a blood vessel of a patient, said catheter having an interior space and an opening in said distal end portion; placing a sensor in or near said interior space, said sensor being for sensing the concentration of a constituent in the patient'"'"'s blood and providing a signal in response thereto; introducing into said patient at least one of the following components;
a vasodilator component, a vasodilation promotor, a platelet/white cell inhibitor component and a platelet/white cell deactivation promotor; andobtaining said signal while at least one of the following is introduced into said blood vessel;
(1) at least one of said vasodilator component and said vasodilation promotor in an amount effective to reduce the vasoconstriction caused by the presence of said catheter in said blood vessel and (2) at least one of said platelet/white cell inhibitor component and said platelet/white cell deactivation promotor in an amount effective to reduce at least one of;
(A) the platelet activation caused by the presence of said catheter in said blood vessel; and
(B) the white cell activation caused by the presence of said catheter in said blood vessel;
thereby providing a more accurate determination of the concentration of the blood constituent. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification