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Immunoassays for thyroid hormones using thyroglobulin

  • US 5,196,349 A
  • Filed: 10/17/1990
  • Issued: 03/23/1993
  • Est. Priority Date: 12/01/1987
  • Status: Expired due to Term
First Claim
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1. A method for measuring a thyroid hormone in a serum sample which comprises:

  • a. incubating a serum sample with a labeled antibody to a thyroid hormone and a composite comprising a thyroglobulin chemically modified by succinic anhydride immobilized on an insoluble carrier material, to form a complexed composite;

    b. separating the complexed composite from unbound labeled antibody;

    c. measuring the amount of label associated with the complexed composite or associated with the unbound labeled antibody; and

    d. relating the measurement of step c. to the amount of the thyroid hormone in the serum sample.

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