Multiple parameter rate-responsive cardiac stimulation apparatus

• US 5,197,467 A
• Filed: 06/22/1992
• Issued: 03/30/1993
• Est. Priority Date: 06/22/1992
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories Incorporated)
• Inventors: Morris, Robert A., Nolan, James A., Steinhaus, Bruce M., Nappholz, Tibor A., Koestner, Ken
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/902,242
• Time in Patent Office: 281 Days
• Field of Search: 128/419 PG, 128/419 P, 128/734, 128/671, 128/723
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A metabolic demand rate-responsive cardiac stimulation apparatus and method are disclosed which employ multiple physiological rate control parameters, such as respiratory minute volume, patient motion and cardiac stroke volume. The parameters are derived using a single standard pacing lead or transducer. The apparatus and method perform each physiological measurement by periodically applying a measuring current between two points within the apparatus. This measuring current has frequency components in a range of from approximately 10 kilohertz to 1000 megahertz. Application of this measuring current allows the apparatus to detect the voltage which arises from the applied current and, from the detected voltage, to measure the patient'"'"'s spatial impedance. For a particular measurement, the apparatus controls which physiological parameter is sensed by regulating the frequency content of the measuring current. The apparatus analyzes the physiological parameters to determine the best pacing rate in terms of characteristics such as response time and stability.

Claims

1. A metabolic demand rate-responsive cardiac stimulation apparatus, comprising:

means for pacing a patient'"'"'s heart at a controlled rate;

means for measuring impedance within the patient'"'"'s body, said impedance measuring means including means for applying multiple fixed frequencies of measuring currents between two points within said apparatus and means for measuring voltages in response to the application of said measuring currents, said measuring currents having frequency components within a range of from approximately 10 kilohertz to approximately 1000 megahertz;

means for controlling said impedance measuring means to limit the frequency components of the applied measuring currents to lie within at least one predetermined subrange of frequencies such that the measured voltage within each subrange of frequencies corresponds to a measurement of a metabolic demand parameter;

means for deriving at least one metabolic demand parameter from the measured voltage corresponding to each of said at least one predetermined subrange of frequencies; and

means for determining said controlled pacing rate in relation to the values of said at least one derived metabolic demand parameter.

2. An apparatus according to claim 1, wherein said pacing means includes at least one pacing lead, wherein said impedance measuring means includes a means for generating a measuring current, and wherein said current generating means and said voltage measuring means are coupled to said at least one pacing lead.

3. An apparatus according to claim 1, wherein said apparatus further comprises an inductance coil, wherein said impedance measuring means includes a means for generating a measuring current, and wherein said current generating means and said voltage measuring means are coupled to said coil.

4. An apparatus according to claim 1, wherein said measuring current applying means includes a circuit which generates a constant measuring current.

5. An apparatus according to claim 1, wherein said measuring current applying means includes a circuit which generates a measuring current using a constant voltage.

6. An apparatus according to claim 1, wherein said impedance measuring means includes means for generating measuring currents in the form of short-duration, square-wave-like current pulses.

7. An apparatus according to claim 6, wherein said impedance measuring means includes means for generating measuring current pulses having pulse durations in the range from 5 nanoseconds to 20 microseconds.

8. An apparatus according to claim 6, wherein said controlling means includes means for limiting said impedance measuring means to generate measuring current pulses having pulse durations within at least one predetermined subrange of durations.

9. An apparatus according to claim 8, further including second and third derived metabolic demand parameters, wherein said at least one derived metabolic demand parameter is based on patient motion and its associated subrange of pulse durations includes durations shorter than approximately 125 nanoseconds;

wherein said second metabolic demand parameter is based on respiration and its associated subrange of pulse durations includes durations from approximately 50 nanoseconds to approximately 400 nanoseconds; and

wherein said third metabolic demand parameter is based on cardiac hemodynamic signals and its associated subrange of pulse durations includes durations longer than approximately 300 nanoseconds.

10. An apparatus according to claim 9, wherein said means for deriving a metabolic demand parameter includes means for deriving a metabolic demand parameter based on respiration, and wherein said metabolic demand parameter is selected from a group including respiratory rate, respiratory tidal volume and respiratory minute ventilation.

11. An apparatus according to claim 9, wherein said means for deriving a metabolic demand parameter includes means for deriving a metabolic demand parameter based on cardiac hemodynamic signals, and wherein said metabolic demand parameter is selected from a group including paced depolarization gradient, stroke volume and cardiac output.

12. An apparatus according to claim 1, wherein said impedance measuring means includes means for generating measuring currents in the form of short-duration, square-wave-like current pulses, wherein said controlling means includes means for regulating said impedance measuring means to generate measuring current pulses having a predetermined pulse duration, said regulating means regulating, for each of said measuring current pulses, at least one subrange of sampling times with respect to the onset of the current pulse at which said impedance measuring means measures the voltage evoked by the current pulse, and wherein said at least one subrange of sampling times defines a sampling frequency which corresponds to a measurement of a metabolic demand parameter.

13. An apparatus according to claim 12, further including second and third derived metabolic demand parameters, wherein said at least one derived metabolic demand parameter is based on patient motion and its associated subrange of sampling times includes times shorter than approximately 125 nanoseconds;

wherein said second metabolic demand parameter is based on respiration and its associated subrange of sampling times includes times from approximately 50 nanoseconds to approximately 400 nanoseconds; and

wherein said third metabolic demand parameter is based on cardiac hemodynamic signals and its associated subrange of sampling times includes times longer than approximately 300 nanoseconds.

14. An apparatus according to claim 13, wherein said means for deriving a metabolic demand parameter includes means for deriving a metabolic demand parameter based on respiration, and wherein said metabolic demand parameter is selected from a group including respiratory rate, respiratory tidal volume and respiratory minute ventilation.

15. An apparatus according to claim 13, wherein said means for deriving a metabolic demand parameter includes means for deriving a metabolic demand parameter based on cardiac hemodynamic signals, and wherein said metabolic demand parameter is selected from a group including paced depolarization gradient, stroke volume and cardiac output.

16. An apparatus according to claim 1, wherein said impedance measuring means includes means for generating measuring currents in the form of sinusoidal-like oscillating currents.

17. An apparatus according to claim 16, wherein said impedance measuring means includes means for generating measuring oscillating currents having frequency components in the range from 10 kilohertz to 1000 megahertz.

18. An apparatus according to claim 16, wherein said controlling means includes means for limiting said impedance measuring means to generate measuring currents having sinusoidal-like oscillating frequencies within at least one predetermined subrange of frequencies.

19. An apparatus according to claim 18, further including second and third derived metabolic demand parameters, wherein said at least one derived metabolic demand parameter is based on patient motion and its associated subrange of sinusoidal-like oscillating frequencies includes frequencies higher than approximately 8 megahertz;

wherein said second metabolic demand parameter is based on respiration and its associated subrange of oscillating current frequencies includes frequencies from approximately 1 megahertz to approximately 11 megahertz; and

wherein said third metabolic demand parameter is based on cardiac hemodynamic signals and its associated subrange of oscillating current frequencies includes frequencies lower than approximately 4 megahertz.

20. An apparatus according to claim 19, wherein said means for deriving a metabolic demand parameter includes means for deriving a metabolic demand parameter based on respiration, and wherein said metabolic demand parameter is selected from a group including respiratory rate, respiratory tidal volume and respiratory minute ventilation.

21. An apparatus according to claim 19, wherein said means for deriving a metabolic demand parameter includes means for deriving a metabolic demand parameter based on cardiac hemodynamic signals, and wherein said metabolic demand parameter is selected from a group including paced depolarization gradient, stroke volume and cardiac output.

22. An apparatus according to claim 1, wherein said impedance measuring means includes means for generating measuring currents in the form of timed pulses of sinusoidal-like oscillating current.

23. An apparatus according to claim 22, wherein said impedance measuring means includes means for generating timed pulses of an oscillating measuring current having timed pulses of durations of at least 5 nanoseconds and having frequency components in the range of from 10 kilohertz to 1000 megahertz.

24. An apparatus according to claim 23, wherein said controlling means includes means for limiting said impedance measuring means to generate measuring currents having oscillating frequencies within at least one predetermined subrange of frequencies.

25. A method for pacing a rate-responsive cardiac stimulation apparatus at a rate determined by a patient'"'"'s metabolic demand, comprising the steps of:

measuring impedance within the patient'"'"'s body, said impedance measuring step comprising the substeps of applying multiple fixed frequencies of measuring currents between two points within the apparatus and measuring voltages in response to the application of said measuring currents, said measuring currents having frequency components within a range from approximately 10 kilohertz to approximately 1000 megahertz;

controlling the measuring frequency components of the applied measuring currents to lie within at least one predetermined subrange of frequencies such that the measured voltage within each subrange of frequencies corresponds to a measurement of a metabolic demand parameter;

deriving at least one metabolic demand parameter from the measured voltage corresponding to each of said at least one predetermined subrange of frequencies;

determining a controlled pacing rate in relation to the values of said at least one derived metabolic demand parameter; and

pacing a patient'"'"'s heart at said controlled rate.

26. A method according to claim 25, wherein said apparatus includes at least one pacing lead and wherein said impedance measuring step includes the substeps of:

applying said measuring current to said at least one lead; and

measuring the resulting voltage appearing at an input to said at least one lead.

27. A method according to claim 25, wherein said apparatus includes an inductance coil and wherein said impedance measuring step includes the substeps of:

applying said measuring current to said coil; and

measuring the resulting voltage appearing at an input to said coil.

28. A method according to claim 25, wherein said impedance measuring step includes the substep of generating said measuring currents in the form of short-duration, square-wave-like current pulses.

29. A method according to claim 25, wherein said impedance measuring step includes the substep of generating said measuring currents in the form of short-duration, square-wave-like current pulses having pulse durations in the range of from 5 nanoseconds to 20 microseconds.

30. A method according to claim 29, wherein said controlling step includes the substep of regulating said impedance measuring step to generate measuring current pulses having pulse durations within at least one predetermined subrange of durations.

31. A method according to claim 29, wherein said deriving step derives second and third metabolic demand parameters, and wherein said controlling step includes the substep of regulating said impedance measuring step to generate measuring current pulses having pulse durations within predetermined subranges of durations, said at least one derived metabolic demand parameter being based on patient motion and having its associated subrange of durations include pulse durations shorter than approximately 125 nanoseconds, said second metabolic demand parameter being based on respiration and having its associated subrange durations include pulse durations from approximately 50 nanoseconds to approximately 400 nanoseconds, and said third metabolic demand parameter being based on cardiac hemodynamic signals and having its associated subrange of durations include pulse durations longer than approximately 300 nanoseconds.

32. A method according to claim 31, wherein said step of deriving a metabolic demand parameter includes the substep of deriving a metabolic demand parameter based on respiration, said metabolic demand parameter being selected from a group including respiratory rate, respiratory tidal volume and respiratory minute ventilation.

33. A method according to claim 31, wherein said step of deriving a metabolic demand parameter includes the substep of deriving a metabolic demand parameter based on cardiac hemodynamic signals, said metabolic demand parameter being selected from a group including paced depolarization gradient, stroke volume and cardiac output.

34. A method according to claim 31, wherein said controlling step includes the substeps of regulating said impedance measuring step to generate measuring current pulses having a predetermined pulse duration and regulating, for each of said measuring current pulses, at least one subrange of sampling times with respect to the onset of the current pulse at which said impedance measuring step measures the voltage evoked by the current pulse, said at least one subrange of sampling times defining a sampling frequency which corresponds to a measurement of a metabolic demand parameter.

35. A method according to claim 25, wherein said impedance measuring step generates measuring currents in the form of sinusoidal-like oscillating currents.

36. A method according to claim 35, wherein said impedance measuring step generates oscillating measuring currents having frequency components in the range of from 10 kilohertz to 1000 megahertz.

37. A method according to claim 36, wherein said controlling step includes the substep of limiting said impedance measuring step to generating measuring currents having oscillating current frequencies.

38. A method according to claim 35, wherein said deriving step derives second and third metabolic demand parameters, and wherein said controlling step includes the substep of limiting said impedance measuring step to generate measuring currents having oscillating current frequencies within at least one predetermined subrange of frequencies, said at least one derived metabolic demand parameter being based on patient motion and having its associated subrange of oscillating current frequencies include frequencies higher than approximately 8 megahertz, said second metabolic demand parameter being based on respiration and having its associated subrange of oscillating current frequencies include frequencies from approximately 1 megahertz to approximately 11 megahertz, and said third metabolic demand parameter being based on cardiac hemodynamic signals and having its associated subrange of oscillating current frequencies include frequencies lower than approximately 4 megahertz.

39. A method according to claim 38, wherein said step of deriving a metabolic demand parameter includes the substep of deriving a metabolic demand parameter based on respiration, said metabolic demand parameter being selected from a group including respiratory rate, respiratory tidal volume and respiratory minute ventilation.

40. A method according to claim 38, wherein said step of deriving a metabolic demand parameter includes the substep of deriving a metabolic demand parameter based on cardiac hemodynamic signals, said metabolic demand parameter being selected from a group including paced depolarization gradient, stroke volume and cardiac output.

41. A method according to claim 25, wherein said impedance measuring step includes the substep of generating measuring currents in the form of timed pulses of sinusoidal-like oscillating currents.

42. A method according to claim 41, wherein said impedance measuring step includes the substep of generating timed pulses of sinusoidal-like oscillating current having timed pulses of durations of at least 5 nanoseconds and having frequency components in the range from 10 kilohertz to 1000 megahertz.

43. A method according to claim 42, wherein said controlling step includes the substep of limiting said impedance measuring step to generate measuring currents having oscillating current frequencies within at least one predetermined subrange of frequencies, and wherein the measured voltage within each subrange of frequencies corresponds to a measurement of a metabolic demand parameter.

44. A method for pacing a rate-responsive cardiac stimulation apparatus at a rate determined by a patient'"'"'s metabolic demand, comprising the steps of:

measuring impedance within the patient'"'"'s body, said impedance measuring step comprising the substeps of applying multiple fixed frequencies of measuring voltages between two points within the apparatus and measuring currents in response to the application of said measuring voltages, said measuring voltages having frequency components within a range from approximately 10 kilohertz to approximately 1000 megahertz;

controlling the measuring frequency components of the applied measuring voltages to lie within at least one predetermined subrange of frequencies such that the measured current within each subrange of frequencies corresponds to a measurement of a metabolic demand parameter;

deriving at least one metabolic demand parameter from the measured current corresponding to each of said at least one predetermined subrange of frequencies;

determining a controlled pacing rate in relation to the values of said at least one derived metabolic demand parameter; and

pacing a patient'"'"'s heart at said controlled rate.