×

Drug delivery collagen-impregnated synthetic vascular graft

  • US 5,197,977 A
  • Filed: 04/30/1992
  • Issued: 03/30/1993
  • Est. Priority Date: 01/30/1984
  • Status: Expired due to Term
First Claim
Patent Images

1. A synthetic vascular graft comprising:

  • a tubular flexible porous graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min cm2 (purified water at 120 mm Hg);

    the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water insoluble collagen fibrils complexed with an effective amount of a drug and admixed with a plasticizer for rendering the graft blood-tight and flexible and providing for substained release of the drug portion of the complex after immplantation,the collagen fibrils applied by application of an aqueous slurry of water-insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×