Drug delivery collagen-impregnated synthetic vascular graft
First Claim
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1. A synthetic vascular graft comprising:
- a tubular flexible porous graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min cm2 (purified water at 120 mm Hg);
the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water insoluble collagen fibrils complexed with an effective amount of a drug and admixed with a plasticizer for rendering the graft blood-tight and flexible and providing for substained release of the drug portion of the complex after immplantation,the collagen fibrils applied by application of an aqueous slurry of water-insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked.
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Abstract
A collagen impregnated vascular graft including drug materials complexed with the collagen to be released slowly from the graft following implant. The graft is a porous synthetic vascular graft substrate having collagen fixed to the graft substrate and cross-linking the collagen in situ to render the porous substrate blood-tight. The drug materials complexed with the collagen fibrils may include antithrombic agents, antibacterial, antimicrobial agents, antifungal agents and the like.
666 Citations
16 Claims
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1. A synthetic vascular graft comprising:
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a tubular flexible porous graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min cm2 (purified water at 120 mm Hg); the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water insoluble collagen fibrils complexed with an effective amount of a drug and admixed with a plasticizer for rendering the graft blood-tight and flexible and providing for substained release of the drug portion of the complex after immplantation, the collagen fibrils applied by application of an aqueous slurry of water-insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A synthetic vascular graft comprising:
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a tubular flexible porous polyethylene terephthalate graft substrate having a porosity of less than about 3,000 ml/min-cm2 (purified water at 120 mm Hg); the inner surface having been treated with collagen fibrils complexed with a drug and admixed with a plasticizer which extends into the porous structure of the substrate and covers the outer surface; the collagen applied by depositing an aqueous slurry containing between about 0.5 to 5.0 weight percent water-insoluble collagen fibrils and between about 4 to 12 weight percent plasticizer to the lumen of the substrate and massaged through the substrate and dried and cross-linked. - View Dependent Claims (13, 14, 15, 16)
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Specification