Synthesis of amino acid-derived bioerodible polymers

• US 5,198,507 A
• Filed: 12/09/1991
• Issued: 03/30/1993
• Est. Priority Date: 06/12/1990
• Status: Expired due to Term

• Current Assignee: Rutgers University
• Original Assignee: Rutgers University
• Inventors: Pulapura, Satish K. K., Kohn, Joachim B.
• Primary Examiner(s): Buttner, David J.
• Application Number:
  US07/804,767
• Time in Patent Office: 477 Days
• Field of Search: 528/203, 528/204, 525/432, 525/433, 525/434, 525/467, 525/454
• US Class Current: 525/432
• CPC Class Codes: C07C 235/34 having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• CPC Class Codes: C08G 64/12 containing nitrogen
• CPC Class Codes: C08G 69/44 Polyester-amides

Abstract

Novel amino acid-derived polycarbonates and amino acid-derived diphenol compound starting materials from which the polycarbonates are polymerized. Polymer blends of the amino acid-derived polycarbonates with polyiminocarbonates prepared from identical amino acid-derived diphenol starting materials.

Claims

1. An amino acid-derived polycarbonate comprised of one or more recurring structural units represented by the formula:

##STR6## wherein R₁ is an alkyl group up to 18 carbon atoms in length.

2. The polycarbonate of claim 1, which consists essentially of one recurring structural unit.

3. The polycarbonate of claim 1, having a weight-average molecular weight above about 50,000 daltons, measured by gel permeation chromatography relative to polystyrene standards.

4. The polycarbonate of claim 1, wherein R₁ is --(CH₂)₅ --CH₃.

5. A polymer blend comprising a first polymer comprising a polycarbonate, prepared by polymerizing a diphenol starting material with phosgene, and a second polymer comprising apolyiminocarbonate, prepared by polymerizing a diphenol starting material with a reactant selected from the group consisting of cyanogen bromide and dicyanates, wherein said first and second polymers are derived from the same diphenol starting material and wherein said diphenol is an amino acid derivative.

6. The blend of claim 5, wherein said diphenol starting material is desaminotyrosyl-tyrosine hexyl ester.

7. The blend of claim 6, wherein said amino acid derivative comprises desaminotyrosyl-tyrosine hexyl ester.