Method and apparatus for diagnosing vulnerability to lethal cardiac arrhythmias

• US 5,201,321 A
• Filed: 02/11/1991
• Issued: 04/13/1993
• Est. Priority Date: 02/11/1991
• Status: Expired due to Term

• Current Assignee: Bio-Dimensions Incorporated
• Original Assignee: Bio-Dimensions Incorporated
• Inventors: Fulton, Keith W.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/653,190
• Time in Patent Office: 792 Days
• Field of Search: 128/702-706, 364/413.06
• US Class Current: 600/515
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats

Abstract

A method and apparatus for diagnosing the vulnerability of a patient'"'"'s heart to lethal cardiac arrhythmias uses on-line comparison of the beat timing vectors with the stored vectors of a number of previous beats and analyzing the vector differences according to a chaos techniques to obtain an indication of heart condition.

Claims

1. A method of analyzing heart beats to obtain an indication of heart conditions favorable to heart failure comprising the steps of:

(a) measuring a series of N heart beats;

(b) measuring in the N series the relative beat-to-beat timing and providing a series of such measurements; and

(c) analyzing the beat-to-beat timing for chaos in the timing wherein the chaos is represented by an instantaneous value of dimension of the beat timing in a multidimensional representation of the chaos having values up to m dimensions where a healthy heart is represented by a higher dimensional value m and a lower value of m indicates a less healthy heart.

2. The method of claim 1 wherein the most recent heart beat interval added to the series of such measurements becomes the new reference point of the N series of measurements and the chaotic analysis is a function of the comparison between the most recent point and the previous N series of measurements.

3. The method of claim 2 wherein the N series is organized into vectors of m dimensions and a vector (V_t) is constructed in virtual space where the first coordinate V_t (O) is the value of the t^th point X_t, and V_t (i) is the value of X.sub.(t+iτ

) and τ

is the relative time delay.

4. The method of claim 3 wherein distances between the first vector and the other vectors are calculated, and accumulated into a cumulative frequency set where the number of distances less than r is measured for all values of r, from zero to a selected maximum separation distance for the vectors.

5. The method of claim 4 wherein a linear portion of this cumulative set, when logarithmically scaled, defines a scaling region.

6. The method of claim 2 including the first step of defining, for the set of measurements, a first vector in time, and second vector after the first vector;

and

subtracting second and succeeding vectors from an earlier vector to obtain a set of vector differences wherein the differences are analyzed for an indication of relative heartbeat timing chaos.

7. The method of claim 1 wherein beat-to-beat timing is determined for a set of N beats, and the next occurring beat is timed while the oldest beat in the N series is discarded to update a stored file of beats in memory so that real time data input occurs followed by chaos analysis immediately following input of the most recent beat.

8. A method of testing heart conditions contributing to failure comprising the steps of:

(a) forming a series of timing measurements on successive heartbeats wherein the timing is for a series of N length in a serially arranged memory for the timing measurements;

(b) inputting the next occurring beat timing measurement and discarding the oldest beat timing measurement from the N series in memory;

(c) as each of a series of next occurring beat timing measurements is made, performing a new beat timing chaos analysis and providing an output in the form of a single value which indicates the measure of chaos;

(d) as subsequent beat timing measurements occur, obtaining additional timing chaos analysis values indicative of the measure of chaos; and

(e) forming an output record of values indicative of the measure of chaos as an indication of patient heart condition.

9. The method of claim 8 including the step of recording, after each newly measure beat timing input from a patient, the value measuring beat timing chaos and observing that value indicates changes in chaos and patient heart condition.

10. The method of claim 9 including the steps of:

(a) with the N series of beat timing measurements, and a selected value of relative timing τ

, defining a vector in m dimensional space with data from the series at τ

spacing and selecting such data to serve as vector coordinates where the coordinates are, in sequence, 1, 2, 3, and up to m;

(b) varying m from 1 up to a whole number positive integer of selected maximum value;

(c) for a given m value, defining a first vector using the N series at the most recent entries;

(d) for the same m value, defining second and subsequent vectors until the N series is fully used to define vectors;

(e) forming a series of differences for the given m value by subtracting the first vector from all following vectors;

(f) forming a second series of differences for the next larger value of m by subtracting the first vector from all following vectors; and

(g) with the first, second and subsequent series of differences as m increases to the maximum value analyzing all series for values indicative of the measure of chaos.

11. A method for analyzing heart beat timing signals for the presence or absence of conditions indicative of impending heart malfunction comprising the steps of:

(a) converting a series of heart beat signals into serial time measurements;

(b) with the last occurring time measurement, performing a timing chaos analysis of the series of measurements to obtain a measurement of chaos;

(c) repeating the timing chaos analysis of the series of measurements to obtain a measurement of chaos with the next occurring time measurement;

(d) wherein the steps of determining a measurement of chaos represents chaos by determining an arithmatic value therefrom; and

(e) detecting in the chaos arithmatic value a value indicative of impending heart malfunction.