Minute volume rate-responsive pacemaker employing impedance sensing on a unipolar lead

• US 5,201,808 A
• Filed: 02/10/1992
• Issued: 04/13/1993
• Est. Priority Date: 02/10/1992
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories)
• Inventors: Morris, Robert A., Nolan, James A., Steinhaus, Bruce M., Nappholz, Tibor A.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/833,435
• Time in Patent Office: 428 Days
• Field of Search: 128/419 PG
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A rate-responsive pacemaker employing a rate control parameter of respiratory minute volume, derived over a unipolar lead. The pacemaker performs the minute volume measurement by periodically applying a measuring current between the lead and a reference point on the pacemaker case. This measuring current has frequency components in a range from approximately 10 kilohertz to 1000 megahertz. Application of this measuring current allows the pacemaker to detect the voltage which arises from the applied current and, from the detected voltage, to measure the patient'"'"'s spatial impedance. Spatial impedance and minute volume vary as a function of the patient'"'"'s pleural pressure. The pacemaker derives minute volume and rate-responsive pacing rate from the spatial impedance measurement.

Claims

1. A rate-responsive pacemaker comprising:

pulsing means for providing pacing current pulses at a controlled rate;

a unipolar lead coupled to said pulsing means and having an electrode adapted to couple said pulsing means to a patient'"'"'s heart for delivering said pacing current pulses to said heart;

means for periodically applying a measuring current between said lead and a reference point in said pacemaker, said measuring current having frequency components in a range extending from approximately 10 kilohertz to approximately 1000 megahertz;

means operative during the application of said measuring current between said lead and said reference point for measuring the spatial impedance between said lead and said reference point as a function of the patient'"'"'s pleural pressure;

means responsive to said measuring means for determining the patient'"'"'s minute volume; and

means coupled to said pulsing means for changing said controlled rate in accordance with the patient'"'"'s minute volume.

2. A rate-responsive pacemaker according to claim 1, wherein said means for applying a measuring current includes circuitry for generating a constant measuring current.

3. A rate-responsive pacemaker according to claim 1, wherein said means for applying a measuring current includes circuitry for generating a measuring current at a constant voltage.

4. A rate-responsive pacemaker according to claim 1, wherein said measuring current is in the form of short-duration current pulses.

5. A rate-responsive pacemaker according to claim 4, wherein said current pulses have pulse durations ranging from about 5 nanoseconds to about 5 microseconds.

6. A rate-responsive pacemaker according to claim 4, wherein said current pulses have pulse durations which are selected to distinguish and enhance signals arising from at least one particular origin.

7. A rate-responsive pacemaker according to claim 4, wherein said current pulses have pulse durations which are selected to attenuate signals arising from at least one particular origin.

8. A rate-responsive pacemaker according to claim 7, wherein said current pulses have pulse durations which are longer than 50 nanoseconds to attenuate signals arising from motion, and wherein said current pulses have pulse durations which are shorter than 1000 nanoseconds to attenuate signals arising from cardiac electrical signals.

9. A rate-responsive pacemaker according to claim 1, wherein said measuring current is in the form of continuous waves.

10. A rate-responsive pacemaker according to claim 9, wherein said continuous wave current has frequency components in the range from about 10 kilohertz to about 1000 megahertz.

11. A rate-responsive pacemaker according to claim 9, wherein said continuous wave current has frequency components which are selected to distinguish and enhance signals arising from at least one particular origin.

12. A rate-responsive pacemaker according to claim 9, wherein said continuous wave current has frequency components which are selected to attenuate signals arising from at least one particular origin.

13. A rate-responsive pacemaker according to claim 12, wherein, at first predetermined times, said measuring current applying means generates a continuous wave current having frequency components which are greater than 20 megahertz to attenuate signals other than those arising from motion and wherein, at second predetermined times, said measuring current applying means generates a continuous wave current having frequency components which are less than 2 megahertz to attenuate signals other than those arising from cardiac electrical signals.

14. A rate-responsive pacemaker according to claim 1, wherein said measuring current is in the form of timed pulses of continuous waves.

15. A rate-responsive pacemaker according to claim 14, wherein said timed pulses of continuous wave current have frequency components in the range from about 10 kilohertz to about 1000 megahertz.

16. A rate-responsive pacemaker according to claim 14, wherein said timed pulses of continuous wave current have frequency components which are selected to distinguish and enhance signals arising from at least one particular origin.

17. A rate-responsive pacemaker according to claim 14, wherein said timed pulses of continuous wave current have frequency components which are selected to attenuate signals arising from at least one particular origin.

18. A rate-responsive pacemaker according to claim 17, wherein, at first predetermined times, said measuring current applying means generates timed pulses of continuous wave current having frequency components which are greater than 20 megahertz to attenuate signals other than those arising from motion and wherein, at second predetermined times, said measuring current applying means generates timed pulses of continuous wave current having frequency components which are less than 2 megahertz to attenuate signals other than those arising from cardiac electrical signals.

19. A rate-responsive pacemaker according to claim 1, wherein said means for measuring the spatial impedance has a source impedance which is approximately equal to or greater than the load impedance of the patient'"'"'s body.

20. A rate-responsive pacemaker according to claim 19, wherein said means for measuring the spatial impedance has a source impedance in the range from about 200 ohms to about 600 ohms.

21. A rate-responsive pacemaker according to claim 1, wherein said means for measuring the spatial impedance is a capacitive discharge circuit, and wherein such circuit includes a capacitance which has been selected to provide a maximum measured voltage for a predetermined pulse width and load impedance.

22. A rate-responsive pacemaker according to claim 1, wherein said electrode is adapted to be positioned on the heart wall.

23. A rate-responsive pacemaker comprising:

pulsing means for providing pacing pulses at a controlled rate;

a unipolar lead coupled to said pulsing means and having an electrode adapated to couple said pulsing means to a patient'"'"'s heart;

means for periodically introducing a measuring current between said lead and a reference point and measuring the voltage across said lead and said reference point to derive a spatial impedance signal; and

means coupled to said pulsing means for adjusting said controlled rate as a function of said spatial impedance signal.

24. A rate-responsive pacemaker according to claim 23, wherein said electrode is adapted to be positioned on the heart wall.

25. A rate-responsive pacemaker according to claim 23, wherein said measuring current is in the form of short-duration current pulses.

26. A rate-responsive pacemaker according to claim 25, wherein said current pulses have pulse durations ranging from about 5 nanoseconds to about 5 microseconds.

27. A rate-responsive pacemaker according to claim 25, wherein said current pulses have pulse durations which are selected to distinguish and enhance signals arising from at least one particular origin.

28. A rate-responsive pacemaker according to claim 25, wherein said current pulses have pulse durations which are selected to attenuate signals arising from at least one particular origin.

29. A rate-responsive pacemaker according to claim 28, wherein, at first predetermined times, said measuring current applying means generates current pulses having pulse durations which are shorter than 50 nanoseconds to attenuate signals other than those arising from motion and wherein, at second predetermined times, said measuring current applying means generates current pulses having pulse durations which are longer than 1000 nanoseconds to attenuate signals other than those arising from cardiac electrical signals.

30. A rate-responsive pacemaker according to claim 23, wherein said measuring current is in the form of continuous waves.

31. A rate-responsive pacemaker according to claim 30, wherein said continuous wave current has frequency components ranging from about 10 kilohertz to about 1000 megahertz.

32. A rate-responsive pacemaker according to claim 31, wherein said continuous wave current has frequency components which are selected to distinguish and enhance signals arising from at least one particular origin.

33. A rate-responsive pacemaker according to claim 31, wherein said continuous wave current has frequency components which are selected to attenuate signals arising from at least one particular origin.

34. A rate-responsive pacemaker according to claim 23, wherein said measuring current is in the form of timed pulses of continuous waves.

35. A rate-responsive pacemaker according to claim 34, wherein said timed pulses of continuous wave current have frequency components ranging from about 10 kilohertz to about 1000 megahertz.

36. A rate-responsive pacemaker according to claim 35, wherein said timed pulses of continuous wave current have frequency components which are selected to distinguish and enhance signals arising from at least one particular origin.

37. A rate-responsive pacemaker according to claim 35, wherein said timed pulses of continuous wave current have frequency components which are selected to attenuate signals arising from at least one particular origin.

38. A method for pacing a patient'"'"'s heart at a controlled pacing rate in accordance with the patient'"'"'s repiration minute volume signal, comprising the steps of:

providing an implantable pacemaker and a unipolar lead having an electrode for generating and coupling pacing stimulation pulses to the patient'"'"'s heart;

periodically applying a measuring current between said lead and a reference point in said pacemaker, said measuring current having frequency components in a range of from approximately 10 kilohertz to approximately 1000 megahertz;

measuring the spatial impedance between said lead and said reference point in response to said application of measuring current between the lead and the reference point while the spatial impedance varies as a function of the patient'"'"'s pleural pressure;

determining the patient'"'"'s respiratory minute volume based on said spatial impedance measurement; and

changing the controlled pacing rate in accordance with the patient'"'"'s determined minute volume.

39. A method in accordance with claim 38, wherein said measuring current applying step includes the sub-step of applying a constant measuring current.

40. A method in accordance with claim 38, wherein said measuring current applying step includes the sub-step of applying a measuring current at a constant voltage.

41. A method in accordance with claim 38, wherein said measuring current applying step includes the sub-step of applying the measuring current in the form of short-duration current pulses.

42. A method in accordance with claim 38, wherein said measuring current applying step includes the sub-step of applying the measuring current in the form of short-duration current pulses having pulse durations in the range of from 5 nanoseconds to 5 microseconds.

43. A method in accordance with claim 38, wherein said measuring current applying step includes the sub-step of applying the measuring current in the form of continuous waves.

44. A method in accordance with claim 38, wherein said measuring current applying step includes the sub-step of applying the measuring current in the form of continuous waves having a frequency in the range of from 10 kilohertz to 1000 megahertz.