Coronary artery imaging system

• US 5,203,337 A
• Filed: 05/08/1991
• Issued: 04/20/1993
• Est. Priority Date: 05/08/1991
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation), Vascular Profiles LLC
• Original Assignee: Brigham and Women's Hospital Incorporated
• Inventors: Feldman, Charles L.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/697,251
• Time in Patent Office: 713 Days
• Field of Search: 128/660.01, 128/660.04, 128/660.05, 128/661.09, 128/662.02, 128/662.06, 128/916, 128/661.10
• US Class Current: 600/463
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction

Abstract

A coronary artery imaging system is described in which a catheter is provided with a forward looking sonic transducer for measuring fluid flow in arteries without disturbing the flow and a side-looking sonic transducer for imaging the arterial walls.

Claims

1. A method of determining flow in a blood vessel having a wall comprising the steps of:

(a) measuring the geometry of said wall at a location in a segment of said blood vessel that may have an obstruction;

(b) measuring the volumetric flow rate at the location without interfering with the flow in said segment;

(c) determining the local fluid flow conditions at points within cross sections of said vessel at the location from the volumetric flow and geometric measurements.

2. The method of claim 1 wherein the positional location of the measurement is determined.

3. The method of claim 2 wherein the geometry is determined by a transducer in a catheter inserted in the blood vessel and the angle of the transducer with respect to a catheter axis is also measured.

4. The method of claim 1 wherein fluid samples are taken at the location.

5. The method of claim 4 wherein the samples are taken at a location which appears to be relatively stagnant as determined from the measurements.

6. A method of determining flow in a blood vessel having a wall comprising the steps of:

(a) introducing a catheter into the blood vessel and generating a geometric signal indicative of the geometry of the wall at positional location in a segment of said blood vessel that may have an obstruction in proximity to a tip of the catheter;

(b) determining the positional location;

(c) measuring the volumetric flow rate at the location without interfering with the flow in said segment;

(d) determining the blood vessel wall geometry from the geometric signal and determining the local flow conditions at the positional location from the wall geometry determination and the measured volumetric flow.

7. The method of claim 6 wherein the geometry signal is generated by a sonic transducer.

8. The method of claim 7 wherein the angle of the sonic transducer is measured.

9. The method of claim 6 wherein fluid samples are collected at the location.

10. The method of claim 6 wherein the volumetric flow rate is measured without disturbing the local flow at the location.

11. The method of claim 6 wherein the local fluid conditions include the direction and magnitude of local fluid flow and the general equations for fluid flow are stored in a computer and are used along with the volumetric flow and geometric measurements to solve for the local fluid flow conditions.

12. The method of claim 11 wherein the sheer stress at said wall is determined from the local fluid flow.

13. Apparatus for determining fluid flow within a blood vessel having a wall comprising:

(a) geometric measurement means for measuring the geometry of said wall at a location in a segment of said blood vessel that may have an obstruction;

(b) flow measurement means for measuring volumetric flow at the location without interfering with the flow in said segment;

(c) computer means for determining local fluid flow conditions at points within cross sections of said vessel at the location from the volumetric flow and geometry measurements.

14. The apparatus of claim 13 wherein the geometry measurement means comprises a sonic imaging transducer within a catheter inserted in the blood vessel and positioned at the location.

15. The apparatus of claim 14 wherein the flow measurement means comprises a sonic doppler transducer within said catheter.

16. The apparatus of claim 13 wherein the geometry measurement means includes a catheter inserted in the artery and positioned at the location and including location means for determining the location of the catheter.

17. The apparatus of claim 13 further including sampling means for sampling the fluid at the location.

18. The apparatus of claim 13 wherein the local fluid conditions include the direction and magnitude of local fluid flow.

19. The apparatus of claim 18 wherein the computer means includes means for calculating sheer stress at said wall from the local fluid flow conditions.

20. The apparatus of claim 13 wherein the local fluid flow conditions include local fluid velocity and sheer stress on said wall.

21. An imaging system for providing a representation of a blood vessel having a wall comprising:

a) a catheter for insertion into said blood vessel and having;

(i) a first transducer for generating and receiving echo waves reflected from said wall and converting said echo waves into electrical imaging signals;

(ii) a second transducer for generating doppler signals and receiving doppler echo signals indicative of fluid velocity within the blood vessel and converting said doppler signals into flow signals; and

b) location means for deriving location signals indicative of the first transducer location and the second transducer location.

c) an imaging circuit coupled to said first transducer for detecting the imaging signals;

d) a flow circuit coupled to said second transducer for detecting the flow signals;

e) a location circuit for detecting the location signals;

f) a computer in which the basic equations for fluid flow are stored for processing the signals detected from the imaging circuit, flow circuit and location circuit and computing the three-dimensional location in space of the transducers, a three-dimensional representation of a blood vessel wall segment at predetermined locations and an analysis of the local fluid flow through said predetermined locations.

22. The system of claim 21 wherein the location means comprises a sonic transducer.

23. The system of claim 21 wherein the first and second transducers are sonic transducers.

24. The system of claim 21 wherein the catheter is a tubular shaped device and the first transducer comprises an array of piezo-electric elements disposed about the periphery of the catheter for generating a sonic beam transverse to the catheter axis.

25. The system of claim 21 wherein the second transducer generates a forward directed sonic beam in the direction of the catheter axis, whereby the catheter may be situated upstream from a fluid volume within the blood vessel to measure flow in the volume without disturbing the flow.

26. The system of claim 25 wherein the first transducer comprises an array of piezo-electric elements disposed about the periphery of the catheter for generating a sonic beam which extends transverse the longitudinal axis of the catheter and such beam is steered by varying the phase of excitation to the elements.

27. An imaging system for providing a representation of a blood vessel having a wall comprising:

a) a catheter for insertion into a blood vessel and having;

(i) a first transducer for generating a first sonic beam and receiving echo waves reflected from said wall in a segment of said blood vessel that may have an obstruction and converting the echo waves into electrical image signals;

(ii) a second transducer for generating a second sonic beam and receiving doppler echo signals indicative of fluid velocity within the blood vessel without interfering with the flow in said segment and converting said doppler signals into fluid velocity signals; and

b) location means for determining the location of the transducers and generating an electrical location signal therefrom;

c) an imaging circuit coupled to said first transducer for detecting the electrical image signals;

d) a flow circuit coupled to said second transducer for detecting the fluid velocity signals and generating digital fluid velocity signals therefrom;

e) a catheter location circuit coupled to said location means for detecting the location signal and generating a digital location signal therefrom;

f) a computer for accepting the digital signals from the imaging circuit, flow circuit and catheter location circuit and computing the three-dimensional location in space of the catheter and a three-dimensional representation of a blood vessel wall segment at that location and an analysis of the local fluid flow through the segment.

28. The system of claim 27 wherein the second transducer generates a beam which is directed along the longitudinal axis of the catheter so that it can generate doppler shifted echo signals from a fluid volume forward of the catheter without disturbing the flow in the volume.

29. A method of creating a color flow image of fluid flow in a blood vessel having a wall comprising the steps of:

(a) measuring the geometry of the wall at a location in a segment of said blood vessel that may have an obstruction;

(b) measuring the volumetric flow rate at the location without interfering with the flow in said segment;

(c) determining the local fluid flow conditions at points within cross sections of said vessel at the location from the volumetric flow and geometric measurements; and

(d) color encoding local fluid flow such that image hue and intensity reflect direction and speed, respectively, so as to form said color flow image.

30. Apparatus for creating a color flow image of fluid flow within a blood vessel having a wall comprising:

(a) geometric measurement means for measuring the geometry of said wall at a location in a segment of said blood vessel that may have an obstruction;

(b) flow measurement means for measuring volumetric flow at the location without interfering with the flow in said segment;

(c) computer means for determining local fluid flow conditions at points within cross sections of said vessel at the location from the volumetric flow and geometry measurements; and

(d) color encoding means for encoding local fluid flow such that image hue and intensity reflect direction and speed, respectively, so as to form said color flow image.