Transdermal delivery device
First Claim
1. A transdermal agent delivery device, comprising a unitary device having:
- an active agent reservoir adapted to be placed in active agent transmitting relation with a body surface and positioned within an electric field generated by electrically connecting the active agent reservoir to a source of electrical power; and
a passive agent reservoir adapted to be placed in passive agent transmitting relation to a body surface, the passive agent being able to passively diffuse through the passive agent reservoir, the passive agent reservoir being electrically insualted from the electrical field generated by the power source.
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Accused Products
Abstract
A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered from passive reservoir (26) by passive (i.e., non-electrically assisted) diffusion. In one embodiment, the passive drug reservoir (26) is electrically insulated from the active drug reservoir (24). In a second embodiment, both the active and the passive drug are contained in the same reservoir (34). In the second embodiment, the active drug is ionizable while the passive drug is non-ionizable. Most preferably, the active drug is an ionizable form (i.e., a salt form) of the passive drug.
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Citations
28 Claims
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1. A transdermal agent delivery device, comprising a unitary device having:
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an active agent reservoir adapted to be placed in active agent transmitting relation with a body surface and positioned within an electric field generated by electrically connecting the active agent reservoir to a source of electrical power; and a passive agent reservoir adapted to be placed in passive agent transmitting relation to a body surface, the passive agent being able to passively diffuse through the passive agent reservoir, the passive agent reservoir being electrically insualted from the electrical field generated by the power source. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 22)
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19. A method of delivering an agent through a body surface from a unitary device having an actively transported agent reservoir and a nonionizable passively transported agent reservoir, comprising:
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a) placing the reservoir containing the actively transported agent in agent transmitting relation with a body surface; b) placing the reservoir containing the nonionizable passively transported agent in agent transmitting relation with a body surface to passively transport said agent through the body surface; and c) generating an electric field through the reservoir containing the actively transported agent to actively transport said agent through the body surface. - View Dependent Claims (20, 21, 23, 24)
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25. A method of treating pain by delivering a narcotic analgesic from a unitary device having an ionizable, actively transported narcotic analgesic reservoir and a nonionizable passively transported narcotic analgesic reservoir, comprising:
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a) placing the reservoir containing the ionizable narcotic analgesic in narcotic analgesic transmitting relation with a body surface; b) placing the reservoir containing the nonionizable narcotic analgesic in narcotic analgesic transmitting relation with a body surface to passively transport said narcotic analgesic through the body surface; c) dissolving the ionizable narcotic analgesic in a solvent to form narcotic analgesic ions; and d) generating an electric field through the reservoir containing the narcotic analgesic ions to actively transport said narcotic analgesic ions through the body surface. - View Dependent Claims (26, 27, 28)
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Specification