Method for providing general calibration for near infrared instruments for measurement of blood glucose

• US 5,204,532 A
• Filed: 06/18/1991
• Issued: 04/20/1993
• Est. Priority Date: 01/19/1989
• Status: Expired due to Term

• Current Assignee: Futrex, Inc.
• Original Assignee: Futrex, Inc.
• Inventors: Rosenthal, Robert D.
• Primary Examiner(s): Dzierzynski, Paul M.
• Assistant Examiner(s): HANIG, RICHARD E
• Application Number:
  US07/717,198
• Time in Patent Office: 672 Days
• Field of Search: 250/341, 250/339, 250/343, 250/252.19, 128/633, 356/39
• US Class Current: 250/341.5
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61N 5/06 using light
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 2201/129 Using chemometrical methods

Abstract

A method is disclosed for accurately providing general calibration of near-infrared quantitative analysis instruments for almost any individual user. The general calibration method comprises comparing an individual'"'"'s near-infrared spectrum to a plurality of near-infrared spectral clusters. Each near-infrared spectral cluster has a set of calibration constants associated therewith. The calibration constants of the spectral cluster most closely associated with the individual spectra are used to custom calibrate the near-infrared analysis measurement instrument.

Claims

1. A method for calibrating a near-infrared analysis instrument for the measurement of a blood analyte, said method comprising:

(a) obtaining a near-infrared optical absorption measurement through a body part of an individual;

(b) comparing said optical absorption measurement with each spectral cluster of a plurality of spectral clusters, each of said spectral clusters having a set of calibration constants associated therewith;

(c) identifying which of said plurality of spectral clusters corresponds to said optical absorption measurement; and

(d) applying the set of calibration constants associated with the identified spectral cluster to said near-infrared optical absorption measurements to obtain a measurement of said blood analyte.

2. The method as set forth in claim 1, wherein said near-infrared optical measurement is made using energy of between about 600 to about 1000 nanometers.

3. The method as set forth in claim 1, wherein said plurality of spectral cluster is approximately six spectral clusters.

4. The method as set forth in claim 1, wherein said blood analyte is blood glucose levels.