Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
First Claim
1. A method for visualizing organs comprising using a diagnostic or therapeutic agent, wherein said diagnostic or therapeutic agent comprises one or more ultasonic contrast agent composed of microparticles which contain a gas and a polyaminodicarboxylic acid-co-imide derivative of the formula I ##STR4## in which n is 1 or 2x is 1 to 500y is 1 to 500, wherex+y is 2 to 1000, andR is O--R1 or NH--R2, in which R2 is H, (CH2)m --OR1, (CH2)m --O--C(O)--R1 or (CH2)m --O--C(O)--OR1, andm is 2 to 6, andR1 is H, aryl, aralkyl, arylalkenyl, alkyl or C3 -C8 -cycloalkyl or a biologically inactive steroid alcohol or an amino acid, where aryl is unsubstituted or is substituted by C1 -C4 -alkyl, C2 -C4 -alkenyl, C1 -C4 -alkylcarbonyloxy, C1 -C4 -alkoxy or hydroxyl,where the alkyl radicals specified for R1 have 1-22 carbon atoms and the alkenyl radicals have 2-22 carbon atoms, which are not interrupted or are interrupted by a carbonyloxy or oxycarbonyl group, where the repeating units placed in square brackets are distributed randomly and/or in blocks in the polymer, and where both the repeating units labeled with x and those labeled with y are identical or different and where the amino acids are α
- - and/or β
-linked.
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Accused Products
Abstract
The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
370 Citations
3 Claims
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1. A method for visualizing organs comprising using a diagnostic or therapeutic agent, wherein said diagnostic or therapeutic agent comprises one or more ultasonic contrast agent composed of microparticles which contain a gas and a polyaminodicarboxylic acid-co-imide derivative of the formula I ##STR4## in which n is 1 or 2
x is 1 to 500 y is 1 to 500, where x+y is 2 to 1000, and R is O--R1 or NH--R2, in which R2 is H, (CH2)m --OR1, (CH2)m --O--C(O)--R1 or (CH2)m --O--C(O)--OR1, and m is 2 to 6, and R1 is H, aryl, aralkyl, arylalkenyl, alkyl or C3 -C8 -cycloalkyl or a biologically inactive steroid alcohol or an amino acid, where aryl is unsubstituted or is substituted by C1 -C4 -alkyl, C2 -C4 -alkenyl, C1 -C4 -alkylcarbonyloxy, C1 -C4 -alkoxy or hydroxyl, where the alkyl radicals specified for R1 have 1-22 carbon atoms and the alkenyl radicals have 2-22 carbon atoms, which are not interrupted or are interrupted by a carbonyloxy or oxycarbonyl group, where the repeating units placed in square brackets are distributed randomly and/or in blocks in the polymer, and where both the repeating units labeled with x and those labeled with y are identical or different and where the amino acids are α - - and/or β
-linked. - View Dependent Claims (2, 3)
- - and/or β
Specification
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- Resources
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Current AssigneeHoechst Aktiengesellschaft (Sanofi )
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Original AssigneeHoechst Aktiengesellschaft (Sanofi )
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InventorsWalch, Axel, Erbel, Raimund, Krone, Volker, Zotz, Rainer, Magerstadt, Michael
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Primary Examiner(s)Foelak, Morton
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Application NumberUS07/955,146Time in Patent Office208 DaysField of Search424/9, 128/632, 128/653 R, 128/660.01, 128/660.02, 128/660.03, 604/22US Class Current600/458CPC Class CodesA61K 49/223 Microbubbles, hollow micros...
