Apparatus and methodology for digital telemetry of biomedical signals

• US 5,205,294 A
• Filed: 02/19/1991
• Issued: 04/27/1993
• Est. Priority Date: 02/19/1991
• Status: Expired due to Fees

• Current Assignee: GE Medical Systems Information Technologies Incorporated (General Electric Company)
• Original Assignee: Pacific Communication Sciences , Inc. (Cirrus Logic Incorporated)
• Inventors: McBride, William C., Flach, Terry E.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/656,704
• Time in Patent Office: 798 Days
• Field of Search: 128/903, 128/696
• US Class Current: 600/508
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: H03L 2207/06 Phase locked loops with a controlled oscillator having at least two frequency control terminals
• CPC Class Codes: H03L 7/103 the additional signal being a digital signal
• CPC Class Codes: H03L 7/189 comprising a D/A converter for generating a coarse tuning voltage
• CPC Class Codes: H04L 25/064 Subtraction of the threshold from the signal, which is then compared to a supplementary fixed threshold
• CPC Class Codes: H04L 27/12 Modulator circuits; Transmitter circuits
• CPC Class Codes: Y10S 128/903 Radio telemetry
• CPC Class Codes: Y10S 331/02 Phase locked loop having lock indicating or detecting means

Abstract

Biomedical information is directly digitally telemetered from the patient through a frequency modulated transmitter to a remote receiver and computer station. DC offset on the biopotential leads and signals from the patient is compensated by converting the output of the amplifier, such as an electrocardiographic amplifier, into digital format, determining the average or DC component of the digital signal, and generating a digital correction word which is then converted into analog form and fed back into the input of the electrocardiographic amplifier to cancel out the DC offset. The same circuitry is used to insert a standard test signal instead of a correction signal and the output of the amplifier is then checked not to determine its DC component, but to determine whether or not the gain of the electrocardiographic amplifier is performing at a predetermined calibration point. If not, a digital correction word is generated and provided as a correction signal to the programmable gain amplifier.

Claims

1. An improvement in a biomedical apparatus for monitoring biopotentials derived from a patient comprising:

instrumentation means for detecting said biopotentials from said patient and for processing an analog signal at said patient corresponding thereto;

analog-to-digital conversion means for converting said analog signals corresponding to said biopotential signals to digital format at the situs of said patient; and

transmitter means for telemetering digital signals corresponding to said digitized biopotential signals generated by said analog-to-digital conversion means, said transmitter means being a tunable frequency modulated radio transmitter,

wherein said digital signals have a pattern characterized by a DC data bias and wherein said tunable frequency modulated radio transmitter comprises;

an averaging means for averaging said pattern of said digital signals to generate a DC value signal of said pattern;

first voltage controlled crystal oscillator means having its control input coupled to said averaging means, said first voltage controlled crystal oscillator means for generating a variable reference frequency dependent upon said DC value signal of said pattern of said digital signals;

a phase detector having its input coupled to an output of said first voltage controlled crystal oscillator means;

a loop filter having an input coupled to an output of said phase detector;

a second voltage controlled oscillator means having a control input coupled to an output of said loop filter, an output of said second voltage control oscillator generating an output frequency of said phase-lock-loop circuit within said tunable frequency modulated radio transmitter;

divider means for feeding back said output frequency to said phase detector divided by a predetermined integer; and

wherein said digital signals is also coupled into said input of said second voltage controlled oscillator means so that said output frequency of said second voltage controlled oscillator means is frequency modulated by said digital signals and so that said DC data bias is compensated by said DC value signal corresponding to an average DC value of said pattern of said digital data,

whereby biomedical information is directly telemetered from a patient in digital format.

2. The improvement of claim 1 further comprising:

receiver means for receiving said telemetered digital signal; and

computer means coupled to said receiver means for processing said digital signals received by said receiver means at a central station remote from said patient.

3. An improvement in a biomedical apparatus for monitoring biopotentials derived from a patient comprising:

instrumentation means for detecting said biopotentials from said patient and for processing an analog signal at said patient corresponding thereto;

analog-to-digital conversion means for converting said analog signals corresponding to said biopotential signals to digital format at the situs of said patient; and

transmitter means for telemetering digital signals corresponding to said digitized biopotential signals generated by said analog-to-digital conversion means, said transmitter means being a tunable frequency modulated radio transmitter,

wherein said tunable frequency modulated radio transmitter includes a phase-lock-loop circuit comprising;

a phase detector having an input for receiving an input frequency, and an output;

a loop filter having an input coupled to the output of said phase detector, and an output;

a voltage controlled oscillator for generating an output frequency in response to a control input coupled to an output from said loop filter;

a divider for feeding back said output frequency to said phase detector divided by a selected integer;

a microcontroller coupled to a lock detect signal from said phase detector, said lock detect signal signifying whether or not said phase-lock-loop circuit has achieved lockup and if not, whether the desired frequency is greater or less than that at which said voltage controlled oscillator is positioned;

a digital-to-analog converter coupled to said microcontroller and controlled thereby, said digital-to-analog controller having an output coupled in turn to said voltage controlled oscillator to preposition said voltage controlled oscillator at a frequency as determined by input to said digital-to-analog converter from said microcontroller.

4. The improvement of claim 3 wherein said voltage controlled oscillator comprises:

a first varicap diode means controlled by said output of said loop filter for fine tuning said voltage controlled oscillator; and

a second varicap diode means controlled by said output from said digital-to-analog converter for prepositioning said voltage controlled oscillator at a predetermined frequency within a selected band.

5. The improvement of claim 4 further comprising:

an analog-to-digital converter having an input coupled to said output of said loop filter and an output coupled to said microcontroller, said microcontroller monitoring said output of said analog-to-digital converter for generating an error compensation signal coupled to said digital-to-analog converter in order to maintain said voltage controlled oscillator at a predetermined operating point notwithstanding component drift and large temperature shifts.

6. The improvement of claim 3 wherein said digital signals have a pattern characterized by a DC data bias and wherein said tunable frequency modulated radio transmitter further comprises:

an averaging means for averaging said pattern of said digital signals to generate a DC value signal;

a compensating voltage controlled crystal oscillator means having its control input coupled to said averaging means, said compensating voltage controlled crystal oscillator means for generating a variable reference frequency dependent upon said DC value signal of said pattern of said digital signals;

wherein said phase detector has its input coupled to said output of said compensating voltage controlled crystal oscillator means; and

wherein said digital data is also coupled into said input of said voltage controlled crystal oscillator so that said output frequency of said controlled crystal oscillator is frequency modulated by said digital data, and so that DC data bias is compensated by said DC value signal corresponding to an average DC value of said pattern of said digital data.

7. The improvement of claim 3 wherein said voltage controlled crystal oscillator has a tuning curve relating frequency of operation and tuning voltage input in said voltage controlled crystal oscillator, and wherein said tuning curve is nonlinear, said microcontroller further comprising means for storing said tuning curve, said microcontroller providing a control signal to said digital-to-analog converter for prepositioning said frequency within said voltage controlled crystal oscillator so that said bandwidth of said phase-lock-loop circuit is substantially constant even though said selected integer dividing said feedback frequency through said divider varies.

8. The improvement of claim 7 wherein said voltage controlled oscillator comprises:

a first varicap diode means controlled by said output of said loop filter for fine tuning said voltage controlled oscillator; and

a second varicap diode means controlled by said output from said digital-to-analog converter for prepositioning said voltage controlled oscillator at a predetermined frequency within a selected bandwidth.

9. An improvement in a biomedical apparatus for monitoring biopotentials derived from a patient comprising:

instrumentation means for detecting said biopotentials from said patient and for processing an analog signal at said patient corresponding thereto;

analog-to-digital conversion means for converting said analog signals corresponding to said biopotential signals to digital format at the situs of said patient; and

transmitter means for telemetering digital signals corresponding to said digitized biopotential signals generated by said analog-to-digital conversion means,

wherein said instrumentation means comprises;

a biopotential amplifier, said biopotential amplifier receiving said biopotential signals from said patient and for generating an output signal, and having an input,

said improvement further comprising;

a microcontroller having an input coupled to said output signal; and

a digital-to-analog converter having an input coupled to said microcontroller, an output of said digital-to-analog converter being fed back to said amplifier as a correction signal, said microcontroller for determining a DC value of said output signal and for generating a correction signal coupled to said input of said digital-to-analog converter so that said DC value is removed from said output signal by signal compensation into said input of said amplifier.

10. The improvement of claim 9 wherein said amplifier is a digitally programmable gain amplifier with adjustable gain controlled by said microcontroller, said microcontroller being programmed to selectively provide a standardized test signal fed back through said digital-to-analog converter to said amplifier, said microcontroller measuring said output signal from said amplifier and generating a control signal to adjust said gain of said amplifier so that said gain is calibrated to a predetermined value.

11. The improvement of claim 10 wherein said amplifier is an electrocardiographic amplifier for receiving electrocardiographic signals from said patient and for producing an electrocardiographic output signal.