Passive shuttle metering device for implantable drug delivery system

• US 5,207,666 A
• Filed: 08/30/1991
• Issued: 05/04/1993
• Est. Priority Date: 08/30/1991
• Status: Expired due to Term

• Current Assignee: Flowonix Medical, Inc.
• Original Assignee: InfusAID, Inc. (Pfizer Inc.)
• Inventors: Makower, Joshua, Idriss, Samir F.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US07/752,798
• Time in Patent Office: 613 Days
• Field of Search: 604/65, 604/93, 604/131, 604/152, 604/246-249, 604/890.1, 604/891.1, 128/DIG. 12, 128/DIG. 13, 417/349, 417/417, 417/469, 417/410 R
• US Class Current: 604/891.1
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: G01F 11/04 of the free-piston type
• CPC Class Codes: G01F 11/16 for liquid or semiliquid
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

A fluid metering device useful in implantable drug delivery systems is coupled between a pressurized fluid source and an outlet conduit to provide discrete flow pulses at a predetermined rate. The metering device consists of a first movable member constrained within a housing and a second movable member retained in a cavity by the first. Alternate positioning of the first member simultaneously fills and empties the cavity in which the second resides, discharging fluid through the conduit. The first movable member can be a planar slider, an axially translatable cylinder or a rotatable cylinder. The second movable member may be a flat shuttle, a sliding bar or a diaphragm.

Claims

1. An implantable delivery device comprising;

a source of fluid under pressure,

a conduit for fluid delivery,

a metering element receiving fluid from said fluid source and delivering discrete fluid pulses to said conduit, said metering element comprising a housing having an inlet in fluid communication with said source, an outlet in fluid communication with said conduit and a cavity in said housing in fluid communication with said inlet and outlet, first movable means mounted in said cavity for movement relative to said inlet and said outlet and second movable means retained by said first movable means and movable relative to said outlet, said second movable means responsive to a pressure difference in said cavity for expelling fluid from said cavity into said outlet, and means to move said first movable means.

2. The implantable device of claim 1 wherein said first movable means comprises a slider mounted in said housing, said slider having a recess with a predetermined volume and said second movable means comprises a shuttle mounted in said recess and movable responsive to said fluid pressure difference in said recess.

3. The implantable device of claim 2 wherein said housing comprises guide means for constraining movement of said slider and defining a path around said slider for fluid to pass from said inlet to said outlet at a predetermined rate.

4. The implantable device of claim 1 further comprising means for controlling said means to move, wherein fluid pulses are delivered from said metering element at a predetermined rate.

5. The implantable device of claim 1 wherein said first movable means comprises cylinder means mounted in said cavity, a yoke holding said cylinder means, said means to move moving said yoke to change the position of said cylinder means in a cavity and said second movable means comprises a cylindrical shuttle mounted in said cavity in axial alignment with said cylinder means.

6. The implantable device of claim 5 wherein said cylinder means comprises a pair of separated cylindrical elements and said cylindrical shuttle is aligned with said separated cylindrical elements.

7. The implantable device of claim 6 further comprising a second outlet, said fluid inlet positioned between said outlets.

8. The implantable device of claim 1 wherein said first movable means comprises a cylindrical member rotatable in said housing, said cylindrical member having a bore positioned perpendicular to the axis of rotation of said cylindrical member, and wherein said second movable means comprises a shuttle positioned in said bore.

9. The implantable device of claim 8 wherein said housing has said inlet and outlet on opposite sides thereof and said cylindrical member is rotatable to align said bore with said inlet and said outlet.

10. The implantable device of claim 1, wherein said first movable means comprises a slider mounted in said housing, said slider having a recess with a predetermined volume and said second movable means comprises a diaphragm deflectable relative to said inlet and said outlet.

11. The implantable device of claim 10 further comprising a second inlet and a second outlet in said housing, said first inlet positioned opposite said second outlet, and said second inlet positioned opposite said first outlet, wherein movement of said slider positions said diaphragm alternately between an inlet and outlet for simultaneous fluid delivery and refill.

12. An implantable delivery device comprising;

a source of fluid under pressure;

a conduit for fluid delivery;

a metering element receiving fluid from said fluid source and delivering discrete fluid pulses to said conduit;

said metering element comprising a housing having an inlet in fluid communication with said source, an outlet in fluid communication with said conduit and a cavity in said housing in fluid communication with said inlet and outlet, first driven movable means mounted in said cavity adjacent said inlet and outlet, second movable means carried by said first movable means and movable relative to said outlet as a function of a pressure differential across said second means, and means to move said first movable means to positions opening and blocking said outlet, wherein by positioning said second means fluid from said source is admitted into said cavity and by subsequent movement of said second movable means relative to said outlet, a pulse of fluid is delivered into said conduit.

13. The implantable device of claim 12, wherein said first movable means comprises a slider mounted in said housing, said slider having a recess and said second movable means comprises a flat shuttle mounted in said recess and movable responsive to a fluid pressure differential in said recess.

14. The implantable device of claim 13, wherein said housing comprises guide means for constraining movement of said slider and defining a path around said slider for fluid to pass from said inlet to said outlet at a predetermined rate.

15. The implantable device of claim 12 further comprising means for controlling said means to move, wherein fluid pulses are delivered from said metering element at a predetermined rate.

16. The implantable device of claim 12, wherein said first movable means comprises a segmented cylinder mounted in said cavity, a yoke holding said segmented cylinder, said means to move attached to said yoke to change the position of said segmented cylinder in said cavity and said second movable means comprises a cylindrical shuttle mounted in said cavity in axial alignment with said segmented cylinder and between segments thereof.

17. The implantable device of claim 16, wherein said cylinder comprises a pair of axially aligned cylindrical segments and said cylindrical shuttle is aligned with said cylindrical segments.

18. The implantable device of claim 17 further comprising a second outlet, said fluid inlet positioned between said outlets.

19. The implantable device of claim 12, wherein said first movable means comprises a cylindrical member rotatable in said housing, said cylindrical member having a bore positioned perpendicular to the axis of rotation of said cylindrical member, and wherein said second movable means comprises a shuttle positioned in said bore.

20. The implantable device of claim 19, wherein said housing has said inlet and outlet on opposite sides thereof and said cylindrical member is rotatable to align said bore with said inlet and said outlet.

21. The implantable device of claim 12, wherein said first movable means comprises a slider mounted in said housing, said slider having a recess with a predetermined volume and said second movable means comprises a diaphragm deflectable relative to said inlet and said outlet.

22. The implantable device of claim 21 further comprising a second inlet and a second outlet in said housing, said first inlet positioned opposite said second outlet, and said second inlet positioned opposite said first outlet, wherein movement of said slider positions said diaphragm alternately between an inlet and outlet for simultaneous fluid delivery and refill.

23. The implantable device of claim 12, wherein said means to move said first movable means comprises a magnet positioned in said housing and a shape memory alloy coupled to said magnet to move it and thereby drive said first movable means.