Filter units

• US 5,208,161 A
• Filed: 02/26/1990
• Issued: 05/04/1993
• Est. Priority Date: 08/27/1987
• Status: Expired due to Term

• Current Assignee: Whatman PLC (GE Aerospace)
• Original Assignee: Polyfiltronics N.A., Inc.
• Inventors: Saunders, Anthony J., Manns, Roy L.
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Bhat, N.
• Application Number:
  US07/465,142
• Time in Patent Office: 1,163 Days
• Field of Search: 435/287, 435/310, 435/803, 435/286, 435/7.35, 210/232, 210/323.1, 210/406, 210/416.1, 422/101, 422/102
• US Class Current: 422/534
• CPC Class Codes: B01D 61/146 comprising multiple ultrafiltration steps
• CPC Class Codes: B01D 61/1471 comprising multiple microfiltration steps
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 61/20 Accessories; Auxiliary operations
• CPC Class Codes: B01D 63/08 Flat membrane modules
• CPC Class Codes: B01D 63/087 Single membrane modules
• CPC Class Codes: B01L 2400/0409 centrifugal forces
• CPC Class Codes: B01L 2400/049 vacuum
• CPC Class Codes: B01L 3/50255 Multi-well filtration
• CPC Class Codes: C12M 47/02 Separating microorganisms from the culture medium; Concentration of biomass separating microorganisms from their culture media C12N1/02
• CPC Class Codes: G01N 1/40 Concentrating samples
• CPC Class Codes: G01N 1/4077 by other techniques involving separation of suspended solids
• CPC Class Codes: G01N 2001/2873 Cutting or cleaving
• CPC Class Codes: G01N 2001/288 Filter punches
• CPC Class Codes: G01N 33/5302 Apparatus specially adapted for immunological test procedures
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing

Abstract

An assay filter unit where the filter of the unit is sealed into the body of the unit to prevent any passage of material to be assayed round the edge of the filter but is removable by breaking out a filter support grid along a predetermined line of weakness, together with the filter, for assay of material retained on the filter.

Claims

1. An assay filter unit for filtering a sample and comprising, in combination:

a body having an internal passageway;

a filter disposed within said passageway;

a filter support means for supporting said filter and seal within said body so as to prevent passage of any of said sample around the edges of said filter, and provided with a line of mechanical weakness disposed peripherally about said support means so that said filter is removable from said body by breaking said support means along said line.

2. A filter unit according to claim 1 wherein said filter support means is a grid and said line of weakness is formed, at least in part, by notches of stress-concentrating form in elements of said grid.

3. A filter unit according to claim 2 wherein said body and said grid are integrally molded together of synthetic polymer.

4. A filter unit according to claim 3 wherein the axial thickness of said grid at said notches is predetermined to allow for both ready flow of material during molding and for ready breaking out of the grid after use.

5. A filter unit according to claim 4 wherein said axial thickness at said notches is in the range of about 0.15 to 0.5 mm.

6. A filter unit according to claim 4 wherein said axial thickness at said notches is in the range of about 0.2 to 0.3 mm.

7. A filter unit according to claim 1 wherein said unit is formed of synthetic polymer and includes a ring clamping said filter against the periphery of said support grid and welded in place.

8. A filter unit according to claim 7 wherein said body and said ring, where they abut said filter, have surfaces of roughness sufficient to improve the grip on said filter.

9. A filter unit according to claim 1 wherein disposed within a suction manifold having a plurality of stations for receiving a corresponding number of similar units, and an anvil over which, successively, said body of each said unit can be placed to break out the corresponding said grid along the corresponding line of weakness.

10. A filtration assembly, comprising, in combination, a plurality of assay units, each comprising:

a body having an internal passageway;

a filter disposed within said passageway;

a filter support means for supporting said filter and seal within said body so as to prevent passage of any of said sample around the edges of said filter, and provided with a line of mechanical weakness disposed peripherally about said support means so that said filter is removable from said body by breaking said support means along said line;

said units being stacked for passage of filtrate therethrough from one to successive units.