Synthetic apparatus for inspection of blood

• US 5,209,903 A
• Filed: 09/04/1990
• Issued: 05/11/1993
• Est. Priority Date: 09/06/1989
• Status: Expired due to Term

• Current Assignee: Toa Medical Electronics Co., Ltd.
• Original Assignee: Toa Medical Electronics Co., Ltd.
• Inventors: Inoue, Takahiro, Aota, Kensaku, Kanamori, Shigeo, Demachi, Takashi
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Wallenhorst, Maureen
• Application Number:
  US07/577,689
• Time in Patent Office: 980 Days
• Field of Search: 422/65, 422/67, 422/63, 422/64, 422/99, 422/44, 436/47, 436/48
• US Class Current: 422/65
• CPC Class Codes: G01N 1/2813 Producing thin layers of samples on a substrate, e.g. smearing, spinning-on G01N1/30 takes precedence
• CPC Class Codes: G01N 15/1468 with spatial resolution of the texture or inner structure of the particle
• CPC Class Codes: G01N 2015/014 Reticulocytes
• CPC Class Codes: G01N 2035/00039 Transport arrangements specific to flat sample substrates, e.g. pusher blade
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00138 Slides
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/1025 Fluid level sensing
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/00603 Reinspection of samples
• CPC Class Codes: G01N 35/026 having blocks or racks of reaction cells or cuvettes
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line

Abstract

A blood analyzer system incorporates a conveyor for handling and transporting sample blood through at least one blood analyzer and an automatic blood smear generator under the control of a programmable controller. Blood samples are stored in sample containers having identifiers for the sample blood that they contain. These sample containers are transported through the system in protective racks that permit the reading of the identifiers. The results of analysis by one or more blood analyzers in the system determine the need for performing or omitting subsequent operations on a particular sample blood. When a smeared blood sample is to be made, the controller assures that the smear thickness is consistent with other samples regardless of the thickness or viscosity of the sample blood. If the system fails to make a required smeared blood sample, a detector sounds an alarm, warning of a system failure.

Claims

1. Apparatus for automatic processing of blood, comprising:

a conveyor for transporting a plurality of blood samples;

at least one blood analyzer disposed along said conveyor for analyzing said blood samples;

a blood processing device disposed along said conveyor after said at least one blood analyzer;

first means for actuating said blood processing device in response to a result from said at least one blood analyzer;

said blood processing device including a smear generator means for producing a smear of blood on a slide;

said first means for actuating including means for bypassing said smear generator means in response to a first result of said at least one blood analyzer; and

said first means for actuating further including means for operating said smear generator means to produce a smear in response to a second result of said at least one blood analyzer.

2. Apparatus according to claim 1, wherein:

said at least one blood analyzer includes a blood corpuscle analyzer and a reticulate red blood corpuscle analyzer;

said blood processing device includes a smear generator means for producing a smear of blood on a slide; and

said first means for actuating are responsive to a result of one of said blood corpuscle analyzer and said reticulate red blood corpuscle analyzer.

3. Apparatus according to claim 1, wherein second means for actuating is effective for selectively actuating less than all of said at least one blood analyzer and said blood processing device in response to an external input.

4. Apparatus for automatic processing of blood, comprising:

a conveyor for transporting a plurality of sample racks containing a plurality of sample containers;

each of said sample containers being adapted to contain a blood sample;

at least one blood analyzer disposed along said conveyor for analyzing said blood sample;

a smear generator means disposed along said conveyor after said at least one blood analyzer for producing a smear of blood on a slide;

a controller for actuating said conveyor, said at least one blood analyzer, and said smear generator means;

said controller being effective for operating said conveyor to selectively supply, in response to a condition set in advance, at least one of said sample containers to said at least one blood analyzer;

said controller being responsive to a result from said at least ne blood analyzer, whereby the controller directs said smear generator means to selectively prepare a smear specimen from a blood sample in said at least one sample container supplied to the at least one blood analyzer depending upon said result; and

said controller including means for selecting at least one smearing condition for a blood sample in said at least one sample container supplied to the at least one blood analyzer.

5. Apparatus according to claim 4, further comprising:

an identifying bar code label fastened to each of said containers;

a first bar code reader in said at least one blood analyzer; and

a second bar code reader in said smear generator means.

6. Apparatus according to claim 5, wherein said at least one blood analyzer includes a blood corpuscle analyzer and a reticulate red blood corpuscle analyzer.

7. Apparatus according to claim 4, wherein said smear generator means uses the wedge method of smearing a blood sample, whereby said smear generator means includes means for drawing a smearing glass through said blood sample along its long side to smear blood on a slide.

8. Apparatus according to claim 7, wherein said means for selecting includes means for selecting at least one of:

a drop volume of blood to be applied to a slide,

an angle of a smearing glass relative to said slide, and

a speed of said smearing glass past said slide

as the at least one smearing condition.