Pharmaceutical compositions

• US 5,210,083 A
• Filed: 03/19/1991
• Issued: 05/11/1993
• Est. Priority Date: 07/17/1986
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Pfirrmann, Rolf W.
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US07/672,010
• Time in Patent Office: 784 Days
• Field of Search: 514/222.5
• US Class Current: 514/222.5
• CPC Class Codes: A61K 31/54 having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00

Abstract

An aqueous solution containing a bacterially effective concentration of taurolidine and/or taurultam together with a parenterally acceptable polyol. The aqueous solution is particularly suitable for parenteral administration.

Claims

1. A liquid pharmaceutical composition for parenteral infusion or injection into a patient comprising a liquid aqueous solution containing a bactericide selected from the group consisting of 1-5 weight % of taurolidine and 1-7.5 weight % of taurultam, together with 3-40 weight % of a parenterally acceptable polyol.

2. A pharmaceutical composition as claimed in claim 1 wherein the polyol is glycerol, a sugar or a sugar alcohol.

3. A pharmaceutical composition as claimed in claim 2 wherein the sugar alcohol is sorbitol or xylitol.

4. A pharmaceutical composition as claimed in claim 1 wherein the polyol is glucose.

5. A pharmaceutical composition as claimed in claim 4 comprising taurolidine at a concentration in the range 3 to 4% by weight and glucose at a concentration in the range 15 to 25% by weight.

6. A pharmaceutical composition as claimed in claim 1 wherein the polyol is fructose.

7. A pharmaceutical composition as claimed in claim 1 wherein the concentration of taurolidine is in the range 2 to 3% by weight or the concentration of taurultam is in the range of 3 to 5% by weight.

8. A pharmaceutical composition as claimed in claim 1 further comprising an additive selected from the group consisting of an electrolyte, one or more amino acids, trace elements and vitamins.

9. A pharmaceutical composition as claimed in claim 1 wherein the concentration of taurolidine is in the range of 2 to 3% by weight.

10. A pharmaceutical composition as claimed in claim 1 wherein the concentration of taurultam is in the range 3 to 5% by weight.