Pupil pathway analyzer

• US 5,210,554 A
• Filed: 10/23/1990
• Issued: 05/11/1993
• Est. Priority Date: 12/11/1989
• Status: Expired due to Fees

• Current Assignee: Pulse Medical Instruments Incorporated
• Original Assignee: Pulse Medical Instruments Incorporated
• Inventors: Rothberg, Michael, Sibley, Robert W., Homsy, George, Cornsweet, Tom N.
• Primary Examiner(s): Arnold, Bruce Y.
• Assistant Examiner(s): Dang, Hung Xuan
• Application Number:
  US07/602,137
• Time in Patent Office: 931 Days
• Field of Search: 351/204, 351/206, 351/211, 351/214, 351/221
• US Class Current: 351/206
• CPC Class Codes: A61B 3/0058 for multiple images
• CPC Class Codes: A61B 3/112 for measuring diameter of pupils
• CPC Class Codes: A61B 3/113 for determining or recording eye movement

Abstract

A pupil function analyzer has three major subsystems; an electro-optical system, an electronic interface system and a computer/software system. The electro-optical system can, in turn, be described in terms of three subsystems; one that delivers controlled lights to the patient'"'"'s eyes, another that forms images of the two pupils on a video camera, and a third that moves the optics to maintain alignment with the patient'"'"'s eyes. The electronic interface system converts signals from the video camera into digital signals to be read by the computer and also responds to the computer to move motors for the maintenance of optical alignment and also operates the light stimuli. The computer/software saves and analyzes the signals sent by the electronic interface, controls the alignment motors, and provides an operator interface, so that the operator can select tests and examine the results.

Claims

1. In an ophthalmological instrument for examination of pupillary responses and extrinsic eye muscle balance including pupil imaging optics, a video camera having a photosensitive image plane on which images of a patient'"'"'s pupils are focussed by the pupil imaging optics, a programmed computer, light stimulus devices for selectively stimulating the retinas of a patient'"'"'s eyes under the control of said computer, and a display screen connected to said video camera for providing a display of a patient'"'"'s pupils as they react to said light stimulus devices and also displaying text and graphics generated by said computer, said computer being programmed to perform the method comprising the steps of:

tracking a patient'"'"'s pupils by moving said imaging optics to maintain images of the patient'"'"'s pupils on selected portions of said photosensitive image plane;

displaying a graphical user interface on said display screen providing a user of said instrument with a selection of choices of commands or actions;

monitoring a user input for a selection of one of said choices and, in response to a user selection, displaying a menu of options for the selected choice;

running a test selected by the user by controlling said light stimulus devices and measuring a patient'"'"'s pupillary responses to light stimulation; and

analyzing the patient'"'"'s pupillary response data and displaying in graphical and tabular form the analyzed data for the test.

2. The method recited in claim 1 further comprising the steps of:

repeating a pattern of stimuli by said light stimulus devices;

monitoring a patient'"'"'s eyes for blinks during each pattern of stimuli; and

discarding data of measured pupillary responses obtained for a given pattern of stimuli if a blink is detected during that pattern of stimuli.

3. The method recited in claim 1 further comprising the steps of:

displaying images of the patient'"'"'s pupils on said display screen while running a test; and

simultaneously displaying a graphical overlay on said display screen showing a pattern of stimuli during the test.

4. The method recited in claim 1 wherein said ophthalmological instrument further includes a pointing device which is operated by a user of the instrument to make a selection of choices or actions and to make a selection of a menu option.

5. The method recited in claim 4 wherein said pointing device is a light pen.

6. The method recited in claim 4 wherein said pointing device is a trackball.

7. The method recited in claim 1 wherein one of said choices or commands or actions displayed is a test command and the corresponding menu of options displayed with the test command is selected includes perimetry pupil size, swinging flashlight, and impulse response tests and upon a user selection of one or more of said tests the method further comprising the steps of:

displaying images of the patient'"'"'s pupils on said display screen with a graphical overlay showing crosshairs for alignment of the images of the patient'"'"'s pupils and alignment command buttons which may be selected by the user of the instrument to align said images on said crosshairs; and

responding to user selection of said alignment command buttons by moving said imaging optics to move said images of the patient'"'"'s pupils on said display screen in directions corresponding to selected alignment buttons.

8. The method recited in claim 7 further comprising the step of responding to a user input indicating that the images of the patient'"'"'s pupils are aligned on said crosshairs by removing said crosshairs from the display and beginning said step of tracking.

9. The method recited in claim 7 further including for predetermined ones of said tests the additional step of displaying a further graphical menu showing, for each of the patient'"'"'s eyes, four quadrants which may be selected for defining stimuli to corresponding quadrants of the retinas of the patient'"'"'s eyes.

10. The method recited in claim 9 further comprising the steps of:

displaying images of the patient'"'"'s pupils on said display screen while running a test; and

simultaneously displaying a graphical overlay on said display screen showing, during a test, a pattern of stimuli selected by the user.

11. The method recited in claim 7 wherein said ophthalmological instrument further includes a light pen which is operated by a user of the instrument to make a selection of choices or actions, to make a selection of a menu option and to make selections of said alignment command buttons.

12. The method recited in claim 7 further comprising the steps of:

displaying images of the patient s pupils on said display screen while running a test; and

simultaneously displaying a graphical overlay on said display screen showing a pattern of stimuli during the test.

13. The method recited in claim 1 further comprising the steps of:

repeating a pattern of stimuli by said light stimulus devices;

monitoring a patient'"'"'s eyes for blinks during each pattern of stimuli;

discarding data of measured pupillary responses obtained for a given pattern of stimuli if a blink is detected during that pattern of stimuli;

monitoring the tracking of the patient'"'"'s pupils during a tests; and

if tracking is lost during a test, determining if a sufficient number of pattern of stimuli have been run to provide useful data for the test and, if so, performing said step of analyzing, otherwise, stopping the test and notifying the user of the instrument that tracking has been lost.

14. The method recited in claim 1 wherein one of said choices or commands or actions displayed is a test command and the corresponding menu of options displayed with the test command is selected includes perimetry pupil size, swinging flashlight, and impulse response and upon a user selection of one or more of said tests the method further comprising the steps of:

displaying images of the patient'"'"'s pupils on said display screen with a graphical overlay showing crosshairs for alignment of the images of the patient'"'"'s pupils and alignment command buttons which may be selected by the user of the instrument to align said images on said crosshairs;

responding to user selection of said alignment command buttons by moving said imaging optics to move said images of the patient'"'"'s pupils on said display screen in directions corresponding to selected alignment buttons;

responding to a user input indicating that the images of the patient'"'"'s pupils are aligned on said crosshairs by removing said crosshairs from the display and beginning said step of tracking;

displaying images of the patient'"'"'s pupils on said display screen while running a test;

simultaneously displaying a graphical overlay on said display screen showing a pattern of stimuli during the test;

repeating a pattern of stimuli by said light stimulus devices;

monitoring a patient'"'"'s eyes for blinks during each pattern of stimuli;

discarding data of measured pupillary responses obtained for a given pattern of stimuli if a blink is detected during that pattern of stimuli;

monitoring the tracking of the patient'"'"'s pupils during a test; and

if tracking is lost during a test, determining if a sufficient number of pattern of stimuli have been run to provide useful data for the test and, if so, performing said step of analyzing, otherwise, stopping the test and notifying the user of the instrument that tracking has been lost.

15. The method recited in claim 1 further comprising, during the step of running a test, the steps of:

periodically comparing a video output signal from said video camera with a predetermined reference to detect an image of one of said patient'"'"'s pupils;

in response to the detection of an image of one of said patient'"'"'s pupils, counting clock pulses to generate a current count which is a measure of a chord of the patient'"'"'s pupil;

comparing a stored count with said current count to determine if the stored count is greater than said current count and, if so, storing said current count in place of said stored count; and

at an end of a video field of said video output signal, declaring said stored count as a diameter of the patient'"'"'s pupil.

16. The method recited in claim 15 further comprising the steps of:

counting clock pulses from a reference point until an image of one of said patient'"'"'s pupils is detected;

temporarily storing a count corresponding to a distance from said reference point to one of said patient'"'"'s pupils; and

computing from said diameter and said distance a horizontal center of the patient'"'"'s pupil along said diameter.

17. The method recited in claim 16 further comprising the steps of:

counting horizontal sync pulses from said video camera from a second reference point; and

temporarily storing a count corresponding to a second distance from said second reference point to said diameter, said second distance being a vertical center of the patient'"'"'s pupil.

18. The method recited in claim 17 wherein said step of tracking uses said horizontal and vertical centers as inputs to determine a tracking error to move said imaging optics.

19. The method recited in claim 15 wherein said declared diameter is the data measured by said step of measuring.